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The map label for this gene is sahH

Identifier: 21241574

GI number: 21241574

Start: 953982

End: 955424

Strand: Reverse

Name: sahH

Synonym: XAC0804

Alternate gene names: 21241574

Gene position: 955424-953982 (Counterclockwise)

Preceding gene: 21241583

Following gene: 21241568

Centisome position: 18.46

GC content: 63.48

Gene sequence:

>1443_bases
ATGAACGCTGTCACAAAGATCACCCCGCACACCGACTACAAGATTGCCGACATCTCCCTGGCCGATTGGGGCCGCAAGGA
GCTGGACATCGCCGAGCACGAAATGCCGGGCCTGATGTCGATCCGCCGCAAGCACGCGCAGACCAAGCCGCTGAAGGACG
TGCGCATCACCGGCTCGCTGCACATGACCATCCAGACCGCCGTGCTGATCGAAACGCTCAAGGACATCGGCGCCGATGTG
CGCTGGGCCTCGTGCAACATCTTCTCCACCCAGGACCACGCCGCCGCGGCGATCGCCGCGACCGGCACCCCCGTGTTCGC
CTGGAAGGGCGAGACGCTGGAAGAGTATTGGGACTGCACCCTGGACGCGCTGACCTTCACCCTGCCCGACGGCACCCTCA
CCGGCCCGGAGCTGGTGGTGGACGACGGCGGCGACGTCACCCTGCTGATCCACAAGGGCTACGAGCTCGAAAACGGCAGC
ACCTGGGTGGACGAACCAGCCTCCTCGCACGAAGAGGGCGTCATCAAGGCGTTGCTCAAGCGTGTCGCCGTCGAGCGCCC
GGGCTACTGGGGTCGCGTGGTCAAGGACTGGAAGGGCGTCTCCGAAGAGACCACCACCGGCGTGCACCGCCTGTATCAGA
TCGCCGAAGCCGGCAAGCTGCTGATCCCGGCCATCAACGTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACCTCTAC
GGCTGCCGCGAGTCGCTGGCCGATGGCCTCAAGCGCGCAATGGACGTGATGCTGGCCGGCAAGGTCGCCGTGGTCTGCGG
CTACGGCGATGTCGGCAAGGGCAGCGCTGCCTCGCTGCGCGCCTATGGCGCCCGCGTGATCGTCACTGAAATCGACCCGA
TCTGCGCATTGCAGGCGTCGATGGAAGGTTTCGAAGTCAACACCATCGAATCCACCCTGGGCCGTGCCGACATCTACGTC
ACCACCACCGGCAACAAGGACATCATCACCGTCGAGCACCTGCAGGCGATGAAGGACCAGGCCATCGTCTGCAACATCGG
CCACTTCGACAACGAGATCCAGGTCGATGCGCTCAAGGCGCTGAAGGACGTGCAGAAGATCAACATCAAGCCGCAGGTGG
ACAAGTACGTGTTCCCCAACGGCAACGCGATCTTCCTGCTGGCCGACGGCCGCCTGGTGAACCTGGGCTGCGCCACCGGC
CACCCGAGCTTCGTGATGTCCAACTCGTTCGCCAACCAGACCCTGGCCCAGATCGACCTGTGGGAAAAGCGCGACACCTA
CGAGAAGAAGGTCTACATCCTGCCCAAGCACCTGGATGAAGAAGTTGCGCGTCTGCACCTGGAAAAGATCGGCGTGAAGC
TGACCACCCTCACCAAGGACCAGGCCGACTACCTCGGCGTGGACGTGGCTGGCCCGTACAAGCCGGATCATTACCGCTAC
TGA

Upstream 100 bases:

>100_bases
ACTGCACCACAGGTGCAGGTACACGGCCAGGCTCGACCAGCAGTTACCGTTCAACGGCGCCCGGCATTGCAGACATTCGT
TTGCCTACCGGAGCCATTGC

Downstream 100 bases:

>100_bases
GACCTGGGCGCGCGCCCTCGACAGTGTGAATCAACGGGCGCCGCAAGGCGCCCGTTGTGCATCAAGGCCAGGATCGGCAC
GACGTCGAAGCTGGATCTGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGS
TWVDEPASSHEEGVIKALLKRVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRADIYV
TTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY

Sequences:

>Translated_480_residues
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGS
TWVDEPASSHEEGVIKALLKRVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRADIYV
TTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY
>Mature_480_residues
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGS
TWVDEPASSHEEGVIKALLKRVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRADIYV
TTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=59.6153846153846, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI239937451, Length=446, Percent_Identity=58.7443946188341, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI298286489, Length=471, Percent_Identity=46.4968152866242, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI195539337, Length=471, Percent_Identity=46.4968152866242, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI24308043, Length=471, Percent_Identity=46.4968152866242, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI195539349, Length=471, Percent_Identity=46.4968152866242, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI21361647, Length=471, Percent_Identity=45.859872611465, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506425, Length=471, Percent_Identity=60.2972399150743, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320882, Length=486, Percent_Identity=57.4074074074074, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24642172, Length=468, Percent_Identity=61.965811965812, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24656245, Length=459, Percent_Identity=47.7124183006536, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553387, Length=470, Percent_Identity=46.5957446808511, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI45553385, Length=469, Percent_Identity=46.4818763326226, Blast_Score=403, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_XANAC (Q8PP84)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641156.1
- ProteinModelPortal:   Q8PP84
- GeneID:   1154875
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0804
- NMPDR:   fig|190486.1.peg.800
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BioCyc:   XAXO190486:XAC0804-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52800; Mature: 52800

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 63-63 BINDING 142-142 BINDING 203-203 BINDING 233-233 BINDING 237-237 BINDING 238-238 BINDING 290-290 BINDING 325-325 BINDING 394-394

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSL
CCCCEECCCCCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCEEEEECEE
HMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCT
EEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCEEEEECCCCHHHHHCCE
LDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVDEPASSHEEGVIKALLK
EEEEEEECCCCCCCCCEEEEECCCCEEEEEECCEEECCCCEECCCCCCCCHHHHHHHHHH
RVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
HHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQAS
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHC
MEGFEVNTIESTLGRADIYVTTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKA
CCCEEEEHHHHHCCCEEEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCCHHHHHHH
LKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATGHPSFVMSNSFANQTLAQIDL
HHHHHHCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHEEC
WEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSL
CCCCEECCCCCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCEEEEECEE
HMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCT
EEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCEEEEECCCCHHHHHCCE
LDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVDEPASSHEEGVIKALLK
EEEEEEECCCCCCCCCEEEEECCCCEEEEEECCEEECCCCEECCCCCCCCHHHHHHHHHH
RVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
HHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQAS
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHC
MEGFEVNTIESTLGRADIYVTTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKA
CCCEEEEHHHHHCCCEEEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCCHHHHHHH
LKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATGHPSFVMSNSFANQTLAQIDL
HHHHHHCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHEEC
WEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217