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The map label for this gene is fis [C]

Identifier: 21241293

GI number: 21241293

Start: 612956

End: 613228

Strand: Reverse

Name: fis [C]

Synonym: XAC0522

Alternate gene names: 21241293

Gene position: 613228-612956 (Counterclockwise)

Preceding gene: 77748532

Following gene: 21241284

Centisome position: 11.85

GC content: 61.9

Gene sequence:

>273_bases
TTGAACGCAGCCCCCTCTCGTCCTGACACCAGTCGTGGCGCCCCGAAGTCGCCCCTGCGCGAACACGTGGCCCAGTCCGT
TCGCCGTTATCTGCGCGACCTGGACGGCAGCGACGCGGACGACGTTTACGAAATCGTGCTGCGCGAGATGGAGATCCCGT
TGTTCGTCGAAGTGCTCAACCACTGCGAAGGCAATCAGAGCCGCGCTGCGGCGATGCTGGGCATTCATCGGGCAACCTTG
CGCAAGAAGCTTAAAGAGTACGGGCTGACGTAA

Upstream 100 bases:

>100_bases
CGCGACCGCCACGTGGGCGTGGCGAGCGATGAGGTCACGCGCTAGACTCACTCCCCCTCGCCGGCCACGCGTCCCGGCTT
CGTGACACTGGGAATCTCCT

Downstream 100 bases:

>100_bases
GCCGGGAATCGGCAATCGTCACGGCGTGCTTCTGCCAGACGTGGCGCGCACGGGCTCCCGATCACAGCGTGGTGTCGTGC
GGGTCAGCCTTTCGGTTGGC

Product: DNA-binding protein Fis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MNAAPSRPDTSRGAPKSPLREHVAQSVRRYLRDLDGSDADDVYEIVLREMEIPLFVEVLNHCEGNQSRAAAMLGIHRATL
RKKLKEYGLT

Sequences:

>Translated_90_residues
MNAAPSRPDTSRGAPKSPLREHVAQSVRRYLRDLDGSDADDVYEIVLREMEIPLFVEVLNHCEGNQSRAAAMLGIHRATL
RKKLKEYGLT
>Mature_90_residues
MNAAPSRPDTSRGAPKSPLREHVAQSVRRYLRDLDGSDADDVYEIVLREMEIPLFVEVLNHCEGNQSRAAAMLGIHRATL
RKKLKEYGLT

Specific function: Activates Ribosomal RNA Transcription. Plays A Direct Role In Upstream Activation Of rRNA Promoters. Binds To A Recombinational Enhancer Sequence That Is Required To Stimulate Hin-Mediated DNA Inversion. Prevents Initiation Of DNA Replication From Oric.

COG id: COG2901

COG function: function code KL; Factor for inversion stimulation Fis, transcriptional activator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transcriptional regulatory fis family

Homologues:

Organism=Escherichia coli, GI1789661, Length=84, Percent_Identity=46.4285714285714, Blast_Score=88, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FISL_XANAC (Q8PQ10)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640875.1
- ProteinModelPortal:   Q8PQ10
- SMR:   Q8PQ10
- GeneID:   1154593
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0522
- HOGENOM:   HBG509520
- OMA:   EMVLCEV
- ProtClustDB:   PRK00430
- BioCyc:   XAXO190486:XAC0522-MONOMER
- HAMAP:   MF_00166
- InterPro:   IPR005412
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- PIRSF:   PIRSF002097
- PRINTS:   PR01591
- PRINTS:   PR01590

Pfam domain/function: PF02954 HTH_8; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 10133; Mature: 10133

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAPSRPDTSRGAPKSPLREHVAQSVRRYLRDLDGSDADDVYEIVLREMEIPLFVEVLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
HCEGNQSRAAAMLGIHRATLRKKLKEYGLT
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAAPSRPDTSRGAPKSPLREHVAQSVRRYLRDLDGSDADDVYEIVLREMEIPLFVEVLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
HCEGNQSRAAAMLGIHRATLRKKLKEYGLT
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217