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The map label for this gene is bioC [H]

Identifier: 21241157

GI number: 21241157

Start: 454275

End: 455159

Strand: Reverse

Name: bioC [H]

Synonym: XAC0383

Alternate gene names: 21241157

Gene position: 455159-454275 (Counterclockwise)

Preceding gene: 21241158

Following gene: 21241156

Centisome position: 8.79

GC content: 69.04

Gene sequence:

>885_bases
ATGACCAGTACTTTCGACCCCCGCCACGTCCGGCGCGCCTTTGCGCGTGCCGCCAGTACCTATACCGCCGCAGCCGCACT
TCAACGCGAAGCGGAAACCCGCCTGCTCGAATCGCTCGACTACCTGGGCGAGCAGGTGCCCAAGGTGGCGCTGGATGTCG
GCGCCGGCCCCGGCCATGCCAGCGCTGCAATCAAGAAGCGCTGGCCCAAGGCGCAGGTCATCGCGCTGGATCAGGCCATG
CCGATGCTGCGCCAGGCGCGCAAGGCCGCGGGCTGGTGGAAGCCGTTTACGCAGGTGTGCGCCGATGCGCGCGCGCTACC
GGTCGCCGACGGCAGCGTGGATGTGATCTTCAGCAATCTGTGCCTGCAGTGGGTGGAAGACCTGCCGACCGTGTTCGCCG
GTTTCCGCCGCGCGTTGCGCCCGGGTGGGCTGCTGCTGTGCTCCACCTTCGGCCCGGAAACACTGATCGAATTGCGCGAT
GCCTTTGCGCAGAGCGACCCGGCCCCGCACGTCAGCCGCTTTCCGCCGATCGCCCAATTCGGCGATGCCCTGCTGATGTC
CGGGTTCCGCGACCCGGTGCTGGACCGCGACCTGTTCACCCTGACCTACAACGATCTGCCCGCGCTGATGCGCGAACTGC
GTGCGATGGGGGCAACCAATGCACTCAGCAACCGCCGTGCCACCTTGACCGGACGCGGTCGCTTCGTGGCCGCCAGCGCT
GCCTACGAACCGCTGCGGCGGCCGGACGGCACCCTGCCCAGCTCCTGGGAGGTGATCTACGCCCATGCCTGGGCACCGGC
GCCGGGCGCGCCCATCCGCGAACACGGGCATGAGGTCGCCAGCGTGCCGGTCAGCGCCATCCCGATCCGCCGCCGCATCG
ACTGA

Upstream 100 bases:

>100_bases
ATCGATGGCGGCAGCTATCCCGGCACGTTCTAGCGTGGCGTCGTCGCGCACCACGCATCGATTCCCTCCGCCCTAGCCCT
GGGGCGACAATAGCGGCGCC

Downstream 100 bases:

>100_bases
GCGGCGGTACAGAACGTTGGTCGTCGCGCATCCACTGCCGGTGAGACACAGAGTATTGCGCCCCCGCTCATGCTCACCTG
TCAGGCTCGGCGGAGACACT

Product: biotin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTSTFDPRHVRRAFARAASTYTAAAALQREAETRLLESLDYLGEQVPKVALDVGAGPGHASAAIKKRWPKAQVIALDQAM
PMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNLCLQWVEDLPTVFAGFRRALRPGGLLLCSTFGPETLIELRD
AFAQSDPAPHVSRFPPIAQFGDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFVAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID

Sequences:

>Translated_294_residues
MTSTFDPRHVRRAFARAASTYTAAAALQREAETRLLESLDYLGEQVPKVALDVGAGPGHASAAIKKRWPKAQVIALDQAM
PMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNLCLQWVEDLPTVFAGFRRALRPGGLLLCSTFGPETLIELRD
AFAQSDPAPHVSRFPPIAQFGDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFVAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID
>Mature_293_residues
TSTFDPRHVRRAFARAASTYTAAAALQREAETRLLESLDYLGEQVPKVALDVGAGPGHASAAIKKRWPKAQVIALDQAMP
MLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNLCLQWVEDLPTVFAGFRRALRPGGLLLCSTFGPETLIELRDA
FAQSDPAPHVSRFPPIAQFGDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFVAASAA
YEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=245, Percent_Identity=29.3877551020408, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI86792933, Length=152, Percent_Identity=33.5526315789474, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786994, Length=215, Percent_Identity=31.1627906976744, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535003, Length=268, Percent_Identity=24.6268656716418, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922210, Length=254, Percent_Identity=31.496062992126, Blast_Score=120, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 32117; Mature: 31986

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTFDPRHVRRAFARAASTYTAAAALQREAETRLLESLDYLGEQVPKVALDVGAGPGHA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCCHH
SAAIKKRWPKAQVIALDQAMPMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNL
HHHHHHCCCCHHEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHH
CLQWVEDLPTVFAGFRRALRPGGLLLCSTFGPETLIELRDAFAQSDPAPHVSRFPPIAQF
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
GDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFVAASA
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCEEECHH
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCHHHHCCCHHCCCHHCCC
>Mature Secondary Structure 
TSTFDPRHVRRAFARAASTYTAAAALQREAETRLLESLDYLGEQVPKVALDVGAGPGHA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCCHH
SAAIKKRWPKAQVIALDQAMPMLRQARKAAGWWKPFTQVCADARALPVADGSVDVIFSNL
HHHHHHCCCCHHEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHH
CLQWVEDLPTVFAGFRRALRPGGLLLCSTFGPETLIELRDAFAQSDPAPHVSRFPPIAQF
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
GDALLMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFVAASA
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCEEECHH
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIREHGHEVASVPVSAIPIRRRID
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCHHHHCCCHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]