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The map label for this gene is phhA [H]

Identifier: 21240948

GI number: 21240948

Start: 213990

End: 214880

Strand: Reverse

Name: phhA [H]

Synonym: XAC0174

Alternate gene names: 21240948

Gene position: 214880-213990 (Counterclockwise)

Preceding gene: 21240951

Following gene: 21240947

Centisome position: 4.15

GC content: 64.65

Gene sequence:

>891_bases
ATGACTACCGCTCCGCAACGCGTCGAAAACCAGCTCACCGACAAGGGCTATGTCCCGGTCTACACCACTGCGGTGGTGGA
GCAGCCGTGGGACGGCTACAGCGCCGACGACCACGCCACCTGGGGCACCTTGTATCGGCGCCAGCGCGAGCTGCTGGTCG
GTCGCGCCTGCGAGGAGTTCCTGCAGGCGCAGGATGCGATGGGCATGGGCCAGACGCACATCCCGCGCTTCGATGCGCTC
AATCGCGTGCTGCAGGCAGCCACCGGCTGGACCCTGGTCGGCGTGCAGGGCCTGCTGCCGGAGCTGGATTTCTTCGATCA
CCTGGCCAACAGGCGCTTCCCGGTGACCTGGTGGATCCGCCGGCCCGATCAGATCGATTACATCGCCGAACCCGATCTGT
TCCATGACCTGTTCGGGCATGTGCCGTTGTTGATGAACCCGCTGTTTGCCGACTTCATGCAGGCCTATGGCCGCGGCGGG
GTCAAGGCGCACGGCATCGGCCCGGACGCGCTGCAGAACCTCACCCGGCTGTATTGGTACACGGTGGAATTCGGTCTGAT
CGACACGCCCCAGGGCCTGCGCATCTACGGTGCCGGCATCGTGTCGTCCAAGGGCGAATCGCTGTATTCGCTGGAATCGC
CGGCACCCAACCGCATCGGGTTCGACCTGCAACGCATCATGCGCACGCGCTACCGCATCGACAGCTTTCAGAAGACCTAT
TTCGTCATCGACAGCTTTGCGCAGTTGATGGAAGCCACTGCGCCGGACTTCACCCCGATCTATGCCGAGCTTGCACAACA
GCCGCAGATGCCGGCGGGTGACGTGCTGCCGGGCGATCGGGTGATCCAACGCGGCAGCGGCGAGGGTTGGAGCCGCGACG
GCGACGTGTGA

Upstream 100 bases:

>100_bases
ACGGATCTTGCGCCAAGATGCACATGGCACGCAAGATTCGCAATCCCGTTGCGCGGACATCCGGCTAAGGTGAGGCCTGA
TCACCGGGAGGTGCCGCTGC

Downstream 100 bases:

>100_bases
GGTCACTGCTGCGCTAACGCGGCGCCGATCGCGGCGCGCCGCAGTGCCGCCCGGTCACGATGCCGCGATGTGGCCTGCAC
CGACTCGACACCACCGCCAA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTTAPQRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRELLVGRACEEFLQAQDAMGMGQTHIPRFDAL
NRVLQAATGWTLVGVQGLLPELDFFDHLANRRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDALQNLTRLYWYTVEFGLIDTPQGLRIYGAGIVSSKGESLYSLESPAPNRIGFDLQRIMRTRYRIDSFQKTY
FVIDSFAQLMEATAPDFTPIYAELAQQPQMPAGDVLPGDRVIQRGSGEGWSRDGDV

Sequences:

>Translated_296_residues
MTTAPQRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRELLVGRACEEFLQAQDAMGMGQTHIPRFDAL
NRVLQAATGWTLVGVQGLLPELDFFDHLANRRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDALQNLTRLYWYTVEFGLIDTPQGLRIYGAGIVSSKGESLYSLESPAPNRIGFDLQRIMRTRYRIDSFQKTY
FVIDSFAQLMEATAPDFTPIYAELAQQPQMPAGDVLPGDRVIQRGSGEGWSRDGDV
>Mature_295_residues
TTAPQRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRELLVGRACEEFLQAQDAMGMGQTHIPRFDALN
RVLQAATGWTLVGVQGLLPELDFFDHLANRRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGV
KAHGIGPDALQNLTRLYWYTVEFGLIDTPQGLRIYGAGIVSSKGESLYSLESPAPNRIGFDLQRIMRTRYRIDSFQKTYF
VIDSFAQLMEATAPDFTPIYAELAQQPQMPAGDVLPGDRVIQRGSGEGWSRDGDV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=228, Percent_Identity=35.0877192982456, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI88900503, Length=244, Percent_Identity=35.655737704918, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI88900501, Length=244, Percent_Identity=35.655737704918, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI88900505, Length=244, Percent_Identity=35.655737704918, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI31795563, Length=227, Percent_Identity=34.3612334801762, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4759248, Length=227, Percent_Identity=33.920704845815, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=223, Percent_Identity=36.7713004484305, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI115533973, Length=237, Percent_Identity=32.9113924050633, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI115532103, Length=237, Percent_Identity=32.9113924050633, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71980736, Length=218, Percent_Identity=33.4862385321101, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71980731, Length=151, Percent_Identity=31.7880794701987, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62472054, Length=229, Percent_Identity=36.2445414847162, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24660393, Length=229, Percent_Identity=36.2445414847162, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17136776, Length=222, Percent_Identity=32.4324324324324, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17136774, Length=222, Percent_Identity=32.4324324324324, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24654994, Length=246, Percent_Identity=32.1138211382114, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33467; Mature: 33336

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAPQRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRELLVGRACEEF
CCCCHHHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LQAQDAMGMGQTHIPRFDALNRVLQAATGWTLVGVQGLLPELDFFDHLANRRFPVTWWIR
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHCCHHHHHHHHHCCCCCEEEEEE
RPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGVKAHGIGPDALQNLTRLYWY
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
TVEFGLIDTPQGLRIYGAGIVSSKGESLYSLESPAPNRIGFDLQRIMRTRYRIDSFQKTY
EEEECEEECCCCCEEEECCEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FVIDSFAQLMEATAPDFTPIYAELAQQPQMPAGDVLPGDRVIQRGSGEGWSRDGDV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTAPQRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRELLVGRACEEF
CCCHHHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LQAQDAMGMGQTHIPRFDALNRVLQAATGWTLVGVQGLLPELDFFDHLANRRFPVTWWIR
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHCCHHHHHHHHHCCCCCEEEEEE
RPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGVKAHGIGPDALQNLTRLYWY
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
TVEFGLIDTPQGLRIYGAGIVSSKGESLYSLESPAPNRIGFDLQRIMRTRYRIDSFQKTY
EEEECEEECCCCCEEEECCEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FVIDSFAQLMEATAPDFTPIYAELAQQPQMPAGDVLPGDRVIQRGSGEGWSRDGDV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]