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The map label for this gene is mutY [H]

Identifier: 57238632

GI number: 57238632

Start: 1688916

End: 1689935

Strand: Reverse

Name: mutY [H]

Synonym: CJE1792

Alternate gene names: 57238632

Gene position: 1689935-1688916 (Counterclockwise)

Preceding gene: 57238636

Following gene: 57238626

Centisome position: 95.06

GC content: 30.88

Gene sequence:

>1020_bases
ATGCAAAAAAAAGAGCTTGAAAAACTACAAGAAAATTTACTTCTTTGGTATGAAAAAAATGGACGCAAAACTTTACCTTG
GCGTAATTTACAAAGTCAAAATTGTGATGAAAGTTTAAAGCATATTGATAGAGCTTATGGAGTTTATATCAGCGAAATTA
TGCTTCAGCAAACTCAAGTTAAATCAGTTTTGGAAAGGTTTTATTTCCCCTTTTTGCAAAAATTTCCTACTTTAGAAAGT
TTGGCTAATGCTAATGAAGATGAGCTTTTAAAGGCTTGGCAAGGACTTGGTTATTACACTCGTGCTAGAAATTTAAAAAA
GGCAGCTTTAGAATGTGTGGATAAGTTTGAAGCTAAATTACCCAAAGAAGTTGAGGATCTAAAAAAATTAAGCGGTATAG
GAGCTTATACAGCAGGTGCTATAGCTTGTTTTGGTTATGATCAAAAGGTTTCTTTTGTTGATGGTAATATACGCCGTGTG
CTTTCTCGTCTTTTTGCTTTAGAAAATCCTAGCATGAAAGAACTTGAAAAAAGAGCTAAAGAGCTTTTAAATTTAAATCA
TGCTTTTGATCATAACCAAGCCTTGCTTGATATAGGGGCTTTGGTTTGTGTGAGTAAAAATGCAAAGTGTGGGATTTGTC
CTTTGTATGATTTTTGTCAAGGCAAATTTCATACAGAGCTTTATCCAAGAGCTAAAAAAATACTTTATGAGAGTGTAAAT
TTAAATCTTTTTTTGTTTGAATTTAATAAAAAATTTGCCATAGGGCAAAGCCAAGATAAGCTTTATAAGGGTATGTATAA
TTTTCCTTTTTTTAAAGAAGGAGAGTATAAACTTTCTAAAGATATGGGTTTTGTAGGGGAGTTTAAGCACAGCTATACTA
AGTATAAACTTAATATCAAGGTTTATCATCAAATTTTAAACAATGAAAATAAAAATTATGAATTTAAAACCTTAAAAGAG
TTAGAAAGTACCGCACTTTCGGCACTTTCTTTAAAAGCGTTAAAATTAATTAAGCTCTGA

Upstream 100 bases:

>100_bases
TACCTAAACCTTTAAAAAAAGCTAACATGGATATCCTTAATAATTTAATTTGAGCTAATTTTAGCAAAAAATTTTAAAAT
TTTTTGTTATACTCTCATTT

Downstream 100 bases:

>100_bases
TTTTTTAGGCAAACATAAAGTAGCTATAAGCATGATGATTGTAAAAATAGCTATATATATAAAAAAGCCATTTTCTATAC
CTGCATTTTTAAATTGTAAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MQKKELEKLQENLLLWYEKNGRKTLPWRNLQSQNCDESLKHIDRAYGVYISEIMLQQTQVKSVLERFYFPFLQKFPTLES
LANANEDELLKAWQGLGYYTRARNLKKAALECVDKFEAKLPKEVEDLKKLSGIGAYTAGAIACFGYDQKVSFVDGNIRRV
LSRLFALENPSMKELEKRAKELLNLNHAFDHNQALLDIGALVCVSKNAKCGICPLYDFCQGKFHTELYPRAKKILYESVN
LNLFLFEFNKKFAIGQSQDKLYKGMYNFPFFKEGEYKLSKDMGFVGEFKHSYTKYKLNIKVYHQILNNENKNYEFKTLKE
LESTALSALSLKALKLIKL

Sequences:

>Translated_339_residues
MQKKELEKLQENLLLWYEKNGRKTLPWRNLQSQNCDESLKHIDRAYGVYISEIMLQQTQVKSVLERFYFPFLQKFPTLES
LANANEDELLKAWQGLGYYTRARNLKKAALECVDKFEAKLPKEVEDLKKLSGIGAYTAGAIACFGYDQKVSFVDGNIRRV
LSRLFALENPSMKELEKRAKELLNLNHAFDHNQALLDIGALVCVSKNAKCGICPLYDFCQGKFHTELYPRAKKILYESVN
LNLFLFEFNKKFAIGQSQDKLYKGMYNFPFFKEGEYKLSKDMGFVGEFKHSYTKYKLNIKVYHQILNNENKNYEFKTLKE
LESTALSALSLKALKLIKL
>Mature_339_residues
MQKKELEKLQENLLLWYEKNGRKTLPWRNLQSQNCDESLKHIDRAYGVYISEIMLQQTQVKSVLERFYFPFLQKFPTLES
LANANEDELLKAWQGLGYYTRARNLKKAALECVDKFEAKLPKEVEDLKKLSGIGAYTAGAIACFGYDQKVSFVDGNIRRV
LSRLFALENPSMKELEKRAKELLNLNHAFDHNQALLDIGALVCVSKNAKCGICPLYDFCQGKFHTELYPRAKKILYESVN
LNLFLFEFNKKFAIGQSQDKLYKGMYNFPFFKEGEYKLSKDMGFVGEFKHSYTKYKLNIKVYHQILNNENKNYEFKTLKE
LESTALSALSLKALKLIKL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=228, Percent_Identity=37.280701754386, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI115298650, Length=228, Percent_Identity=37.280701754386, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI115298654, Length=228, Percent_Identity=37.280701754386, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI115298652, Length=228, Percent_Identity=37.280701754386, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI6912520, Length=228, Percent_Identity=37.280701754386, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI190358497, Length=228, Percent_Identity=37.280701754386, Blast_Score=168, Evalue=8e-42,
Organism=Escherichia coli, GI1789331, Length=314, Percent_Identity=34.0764331210191, Blast_Score=180, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39412; Mature: 39412

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKELEKLQENLLLWYEKNGRKTLPWRNLQSQNCDESLKHIDRAYGVYISEIMLQQTQV
CCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KSVLERFYFPFLQKFPTLESLANANEDELLKAWQGLGYYTRARNLKKAALECVDKFEAKL
HHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
PKEVEDLKKLSGIGAYTAGAIACFGYDQKVSFVDGNIRRVLSRLFALENPSMKELEKRAK
CHHHHHHHHHHCCCCHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHH
ELLNLNHAFDHNQALLDIGALVCVSKNAKCGICPLYDFCQGKFHTELYPRAKKILYESVN
HHHHCHHHCCCCHHHHHHHHHHEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
LNLFLFEFNKKFAIGQSQDKLYKGMYNFPFFKEGEYKLSKDMGFVGEFKHSYTKYKLNIK
CEEEEEEECCCEECCCCHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHCCCEEEEEHHH
VYHQILNNENKNYEFKTLKELESTALSALSLKALKLIKL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKKELEKLQENLLLWYEKNGRKTLPWRNLQSQNCDESLKHIDRAYGVYISEIMLQQTQV
CCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KSVLERFYFPFLQKFPTLESLANANEDELLKAWQGLGYYTRARNLKKAALECVDKFEAKL
HHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
PKEVEDLKKLSGIGAYTAGAIACFGYDQKVSFVDGNIRRVLSRLFALENPSMKELEKRAK
CHHHHHHHHHHCCCCHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHH
ELLNLNHAFDHNQALLDIGALVCVSKNAKCGICPLYDFCQGKFHTELYPRAKKILYESVN
HHHHCHHHCCCCHHHHHHHHHHEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
LNLFLFEFNKKFAIGQSQDKLYKGMYNFPFFKEGEYKLSKDMGFVGEFKHSYTKYKLNIK
CEEEEEEECCCEECCCCHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHCCCEEEEEHHH
VYHQILNNENKNYEFKTLKELESTALSALSLKALKLIKL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]