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The map label for this gene is nidH

Identifier: 57238223

GI number: 57238223

Start: 617713

End: 618183

Strand: Direct

Name: nidH

Synonym: CJE0684

Alternate gene names: 57238223

Gene position: 617713-618183 (Clockwise)

Preceding gene: 57238228

Following gene: 57238222

Centisome position: 34.75

GC content: 28.87

Gene sequence:

>471_bases
GTGGAAAACGAGAAAAATTATAGACCAAATGTTGCAGCTATTGTTTTATCAAGTTCTTATCCTTTTGAGTGTAAGATTTT
TATAGCTAAAAGAAGTGATATGGATAATATTTGGCAATTTCCACAAGGAGGCATTGATAAAGGTGAAAGTGTCAAAAACG
CTTTATTTAGAGAATTAAAAGAAGAAATAGGCACTGATGAGGTTGAAATCATTGCTGAGTATCCAGAATGGTTGAGTTAT
GATTTTCCGAGTAAAATTGTTAAAAAAATGTATCCTTATGATGGGCAGATTCAAAAATATTTTTTAGTGCGTTTAAAGCA
CGGTGCTACAATCAATATCAATACCAAGCATCCTGAATTTGATGATTATCAATTTGTGAGTGTTAAACAAATTTTTGAAA
TGATTAATCATTTCAAAAAAAATATTTATGTTAAAGTGATCAAATATTTTGAAGAGAAAGGTTATATCTAA

Upstream 100 bases:

>100_bases
AAAAACCCTAAAATATTTTATTAAATTTTTAATGTATTTTAATAAAAATTTGATTTGATTTAGGTTAAAATTATATCCTT
GAGATTTAAGGAAAAATATT

Downstream 100 bases:

>100_bases
AATGCTTATAGTTCAAAAATATGGTGGAACAAGCGTTGGAACACTTGAGCGTATCGAAGCAGTAGCCAATAGGGTTATCC
AAAGTGTGCAACAGGGTGAT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MENEKNYRPNVAAIVLSSSYPFECKIFIAKRSDMDNIWQFPQGGIDKGESVKNALFRELKEEIGTDEVEIIAEYPEWLSY
DFPSKIVKKMYPYDGQIQKYFLVRLKHGATININTKHPEFDDYQFVSVKQIFEMINHFKKNIYVKVIKYFEEKGYI

Sequences:

>Translated_156_residues
MENEKNYRPNVAAIVLSSSYPFECKIFIAKRSDMDNIWQFPQGGIDKGESVKNALFRELKEEIGTDEVEIIAEYPEWLSY
DFPSKIVKKMYPYDGQIQKYFLVRLKHGATININTKHPEFDDYQFVSVKQIFEMINHFKKNIYVKVIKYFEEKGYI
>Mature_156_residues
MENEKNYRPNVAAIVLSSSYPFECKIFIAKRSDMDNIWQFPQGGIDKGESVKNALFRELKEEIGTDEVEIIAEYPEWLSY
DFPSKIVKKMYPYDGQIQKYFLVRLKHGATININTKHPEFDDYQFVSVKQIFEMINHFKKNIYVKVIKYFEEKGYI

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=160, Percent_Identity=36.875, Blast_Score=99, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_CAMJ8 (A8FL05)

Other databases:

- EMBL:   CP000814
- RefSeq:   YP_001482119.1
- ProteinModelPortal:   A8FL05
- SMR:   A8FL05
- STRING:   A8FL05
- GeneID:   5618356
- GenomeReviews:   CP000814_GR
- KEGG:   cju:C8J_0543
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- BioCyc:   CJEJ407148:C8J_0543-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18528; Mature: 18528

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENEKNYRPNVAAIVLSSSYPFECKIFIAKRSDMDNIWQFPQGGIDKGESVKNALFRELK
CCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
EEIGTDEVEIIAEYPEWLSYDFPSKIVKKMYPYDGQIQKYFLVRLKHGATININTKHPEF
HHHCCCCEEHEECCHHHHCCCCHHHHHHHHCCCCCCHHHHHEEEECCCCEEEECCCCCCC
DDYQFVSVKQIFEMINHFKKNIYVKVIKYFEEKGYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MENEKNYRPNVAAIVLSSSYPFECKIFIAKRSDMDNIWQFPQGGIDKGESVKNALFRELK
CCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
EEIGTDEVEIIAEYPEWLSYDFPSKIVKKMYPYDGQIQKYFLVRLKHGATININTKHPEF
HHHCCCCEEHEECCHHHHCCCCHHHHHHHHCCCCCCHHHHHEEEECCCCEEEECCCCCCC
DDYQFVSVKQIFEMINHFKKNIYVKVIKYFEEKGYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA