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The map label for this gene is lysC [H]

Identifier: 57238222

GI number: 57238222

Start: 618185

End: 619387

Strand: Direct

Name: lysC [H]

Synonym: CJE0685

Alternate gene names: 57238222

Gene position: 618185-619387 (Clockwise)

Preceding gene: 57238223

Following gene: 57238221

Centisome position: 34.77

GC content: 35.25

Gene sequence:

>1203_bases
ATGCTTATAGTTCAAAAATATGGTGGAACAAGCGTTGGAACACTTGAGCGTATCGAAGCAGTAGCCAATAGGGTTATCCA
AAGTGTGCAACAGGGTGATCAACTTGTTGTTGTAGTATCTGCAATGAGTGGGGTGACAAATACTCTTATCGAGCAAGCTG
AATATTTTAGTAAAACTCCTAATGGTAAAGATATGGATATGCTTTTAAGCAGTGGAGAGCGTGTAAGCTGTGCTTTACTT
TCTATTGCTTTAAATGAAAAGGGTTATCCTGCTATATCATTTTCTGGGAGAAAAGCGGGAATTATTACAGATAGTGTTTT
TACAAAGGCAAGAATTCATCATATTGATACAAAAGCGATAAAATCAGAACTTCAAAATGGTAAAATAGTCGTTATAGCAG
GTTTTCAAGGTGTAGATGAGGAAGGTAATGTAACTACCTTAGGGCGTGGTGGAAGCGACTTAAGTGCTGTGGCGGTAGCA
GGTGCCTTAAATGCGGATTTGTGTGAAATTTATACCGATGTTGATGGGGTTTATACAACAGATCCAAGAATTGAACCAAA
GGCAAAGAAATTGGATAAAATTTCTTATGAAGAAATGCTTGAACTTGCAAGTTTGGGTGCAAAAGTTTTGCAAAATCGCT
CTGTAGAGCTTGCAAAAAAATTAAATGTTAACTTAGTAACTAGAAGTAGTTTTAACAATAACGAAGGAACAATGATAACA
AAGGAAGATGGAATGGAACAAGCTTTAGTAAGTGGTATTGCTTTGGATAAAAATCAAGCAAGAGTGACTTTAAGAAATGT
AGAAGATAAGCCTGGAATCGCAGCTGAAATTTTTTCTGTTTTGGCAAATGAAAATATTAATGTAGATATGATTATACAAA
ATGTTGGAGTTGATGGCGCTACAAATTTGGGTTTTACAGTTCCTCAAAATGAACTTGAATTAGCCAAAAATGCTATGCAA
AAAATTTTAAGCTCAAAAACAACTATAGAAAGTGATAGTGCTGTAGTAAAAGTTTCTATAGTCGGCGTAGGCATGAAATC
ACATTCAGGAGTGGCAAGTAAAGCTTTTAAAGCTTTAGCTGATGAGGGGATTAATATCGGTATGATTTCTACTAGTGAAA
TTAAAATTTCAATGATAGTTCATGAAAAATACGGAGAACTTGCAGTTAGAGCACTACATGAGTGCTACGGACTTGATAAA
TAA

Upstream 100 bases:

>100_bases
TTTGTGAGTGTTAAACAAATTTTTGAAATGATTAATCATTTCAAAAAAAATATTTATGTTAAAGTGATCAAATATTTTGA
AGAGAAAGGTTATATCTAAA

Downstream 100 bases:

>100_bases
ATGAGTGATTTTTTAAGTTTTACTCTTGAAAATATTCGCAATGGCGGAGCTTTTATGGCATGGTTGGAGTCGCGTCGTTT
AGAATGGGCTCCTTTGATGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLIVQKYGGTSVGTLERIEAVANRVIQSVQQGDQLVVVVSAMSGVTNTLIEQAEYFSKTPNGKDMDMLLSSGERVSCALL
SIALNEKGYPAISFSGRKAGIITDSVFTKARIHHIDTKAIKSELQNGKIVVIAGFQGVDEEGNVTTLGRGGSDLSAVAVA
GALNADLCEIYTDVDGVYTTDPRIEPKAKKLDKISYEEMLELASLGAKVLQNRSVELAKKLNVNLVTRSSFNNNEGTMIT
KEDGMEQALVSGIALDKNQARVTLRNVEDKPGIAAEIFSVLANENINVDMIIQNVGVDGATNLGFTVPQNELELAKNAMQ
KILSSKTTIESDSAVVKVSIVGVGMKSHSGVASKAFKALADEGINIGMISTSEIKISMIVHEKYGELAVRALHECYGLDK

Sequences:

>Translated_400_residues
MLIVQKYGGTSVGTLERIEAVANRVIQSVQQGDQLVVVVSAMSGVTNTLIEQAEYFSKTPNGKDMDMLLSSGERVSCALL
SIALNEKGYPAISFSGRKAGIITDSVFTKARIHHIDTKAIKSELQNGKIVVIAGFQGVDEEGNVTTLGRGGSDLSAVAVA
GALNADLCEIYTDVDGVYTTDPRIEPKAKKLDKISYEEMLELASLGAKVLQNRSVELAKKLNVNLVTRSSFNNNEGTMIT
KEDGMEQALVSGIALDKNQARVTLRNVEDKPGIAAEIFSVLANENINVDMIIQNVGVDGATNLGFTVPQNELELAKNAMQ
KILSSKTTIESDSAVVKVSIVGVGMKSHSGVASKAFKALADEGINIGMISTSEIKISMIVHEKYGELAVRALHECYGLDK
>Mature_400_residues
MLIVQKYGGTSVGTLERIEAVANRVIQSVQQGDQLVVVVSAMSGVTNTLIEQAEYFSKTPNGKDMDMLLSSGERVSCALL
SIALNEKGYPAISFSGRKAGIITDSVFTKARIHHIDTKAIKSELQNGKIVVIAGFQGVDEEGNVTTLGRGGSDLSAVAVA
GALNADLCEIYTDVDGVYTTDPRIEPKAKKLDKISYEEMLELASLGAKVLQNRSVELAKKLNVNLVTRSSFNNNEGTMIT
KEDGMEQALVSGIALDKNQARVTLRNVEDKPGIAAEIFSVLANENINVDMIIQNVGVDGATNLGFTVPQNELELAKNAMQ
KILSSKTTIESDSAVVKVSIVGVGMKSHSGVASKAFKALADEGINIGMISTSEIKISMIVHEKYGELAVRALHECYGLDK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=462, Percent_Identity=30.5194805194805, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1790455, Length=448, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790376, Length=184, Percent_Identity=29.8913043478261, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=375, Percent_Identity=26.4, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 42739; Mature: 42739

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVQKYGGTSVGTLERIEAVANRVIQSVQQGDQLVVVVSAMSGVTNTLIEQAEYFSKTP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCC
NGKDMDMLLSSGERVSCALLSIALNEKGYPAISFSGRKAGIITDSVFTKARIHHIDTKAI
CCCCHHHHHCCCCEEEEEEEEEEECCCCCCEEEECCCCCCEEEHHHHHHHHHHHCHHHHH
KSELQNGKIVVIAGFQGVDEEGNVTTLGRGGSDLSAVAVAGALNADLCEIYTDVDGVYTT
HHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCHHHHHHHCCCCEEEC
DPRIEPKAKKLDKISYEEMLELASLGAKVLQNRSVELAKKLNVNLVTRSSFNNNEGTMIT
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEEECCCCCCCCEEEE
KEDGMEQALVSGIALDKNQARVTLRNVEDKPGIAAEIFSVLANENINVDMIIQNVGVDGA
CCCCHHHHHHHHEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCC
TNLGFTVPQNELELAKNAMQKILSSKTTIESDSAVVKVSIVGVGMKSHSGVASKAFKALA
CCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHH
DEGINIGMISTSEIKISMIVHEKYGELAVRALHECYGLDK
HCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLIVQKYGGTSVGTLERIEAVANRVIQSVQQGDQLVVVVSAMSGVTNTLIEQAEYFSKTP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCC
NGKDMDMLLSSGERVSCALLSIALNEKGYPAISFSGRKAGIITDSVFTKARIHHIDTKAI
CCCCHHHHHCCCCEEEEEEEEEEECCCCCCEEEECCCCCCEEEHHHHHHHHHHHCHHHHH
KSELQNGKIVVIAGFQGVDEEGNVTTLGRGGSDLSAVAVAGALNADLCEIYTDVDGVYTT
HHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCHHHHHHHCCCCEEEC
DPRIEPKAKKLDKISYEEMLELASLGAKVLQNRSVELAKKLNVNLVTRSSFNNNEGTMIT
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEEECCCCCCCCEEEE
KEDGMEQALVSGIALDKNQARVTLRNVEDKPGIAAEIFSVLANENINVDMIIQNVGVDGA
CCCCHHHHHHHHEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCC
TNLGFTVPQNELELAKNAMQKILSSKTTIESDSAVVKVSIVGVGMKSHSGVASKAFKALA
CCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHH
DEGINIGMISTSEIKISMIVHEKYGELAVRALHECYGLDK
HCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]