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The map label for this gene is frdB [H]

Identifier: 57237465

GI number: 57237465

Start: 413023

End: 413748

Strand: Direct

Name: frdB [H]

Synonym: CJE0459

Alternate gene names: 57237465

Gene position: 413023-413748 (Clockwise)

Preceding gene: 57237464

Following gene: 57237466

Centisome position: 23.23

GC content: 35.81

Gene sequence:

>726_bases
ATGAGTAGAAAATTGACAATAAAGGCATTTAAATATAATCCTTTAAGCAAAATTTCTAAACCACATTTTGTGACTTATGA
GCTTGAAGAAACTCCTTTTATGACGGTTTTTGTATGTTTGACTTTGATCCGTGAAAAAATGGATGCGGATCTGAGTTTTG
ACTTTGTTTGTCGTGCAGGGATTTGCGGATCTTGTGCAATGATGATTAATGGAGTGCCAAAACTTGCTTGTAAAACTTTA
ACTAAAGATTATCCTGATGGAGTGATAGAGCTTATGCCTATGCCTGCATTTAGACATATTAAAGATTTAAGCGTGAATAC
AGGAGAGTGGTTTGAAGACATGTGTAAACGCGTTGAAAGCTGGGTGCATAACGAAAAAGAAACTGATATTTCTAAACTTG
AAGAACGTATTGAGCCGGAGGTTGCGGATGAAACTTTTGAACTTGATCGTTGTATAGAGTGTGGAATTTGTGTAGCTTCT
TGTGCAACTAAACTTATGCGTCCAAATTTCATAGCTGCTACAGGACTTTTAAGAACAGCTAGATATTTACAAGATCCGCA
TGACCATAGAAGTGTGGAAGATTTTTATGAATTAGTGGGCGATGATGATGGTGTTTTTGGTTGTATGTCATTGCTTGCTT
GCGAAGATAATTGTCCTAAAGAATTACCTTTACAAAGTAAAATCGCTTACATGAGAAGACAACTTGTCGCTCAAAGAAAT
AAATAA

Upstream 100 bases:

>100_bases
GAAGCTGAAGGCAAAGGTCGTTATGAAATTCAAAACGCTTTAATGCCTTATGAATTACAAGCTAAATATAAAGCACCAAA
CCAAAGAATAGGAGTTGATT

Downstream 100 bases:

>100_bases
ATCTTTCCCCTTTTTAAGGGGAAGATTATGAAAGAATTATTCCAAAAAATTTGGCAAAATGAACTTCAATTTTTAAATTT
TGATGCTAAATTTCAAGATA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSRKLTIKAFKYNPLSKISKPHFVTYELEETPFMTVFVCLTLIREKMDADLSFDFVCRAGICGSCAMMINGVPKLACKTL
TKDYPDGVIELMPMPAFRHIKDLSVNTGEWFEDMCKRVESWVHNEKETDISKLEERIEPEVADETFELDRCIECGICVAS
CATKLMRPNFIAATGLLRTARYLQDPHDHRSVEDFYELVGDDDGVFGCMSLLACEDNCPKELPLQSKIAYMRRQLVAQRN
K

Sequences:

>Translated_241_residues
MSRKLTIKAFKYNPLSKISKPHFVTYELEETPFMTVFVCLTLIREKMDADLSFDFVCRAGICGSCAMMINGVPKLACKTL
TKDYPDGVIELMPMPAFRHIKDLSVNTGEWFEDMCKRVESWVHNEKETDISKLEERIEPEVADETFELDRCIECGICVAS
CATKLMRPNFIAATGLLRTARYLQDPHDHRSVEDFYELVGDDDGVFGCMSLLACEDNCPKELPLQSKIAYMRRQLVAQRN
K
>Mature_240_residues
SRKLTIKAFKYNPLSKISKPHFVTYELEETPFMTVFVCLTLIREKMDADLSFDFVCRAGICGSCAMMINGVPKLACKTLT
KDYPDGVIELMPMPAFRHIKDLSVNTGEWFEDMCKRVESWVHNEKETDISKLEERIEPEVADETFELDRCIECGICVASC
ATKLMRPNFIAATGLLRTARYLQDPHDHRSVEDFYELVGDDDGVFGCMSLLACEDNCPKELPLQSKIAYMRRQLVAQRNK

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=234, Percent_Identity=27.3504273504274, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790596, Length=220, Percent_Identity=30.4545454545455, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786943, Length=241, Percent_Identity=29.8755186721992, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533915, Length=244, Percent_Identity=25.4098360655738, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322987, Length=240, Percent_Identity=25.8333333333333, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137106, Length=232, Percent_Identity=29.3103448275862, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24643156, Length=246, Percent_Identity=26.8292682926829, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27559; Mature: 27428

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
10.0 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
9.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKLTIKAFKYNPLSKISKPHFVTYELEETPFMTVFVCLTLIREKMDADLSFDFVCRAG
CCCCEEEEEECCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCC
ICGSCAMMINGVPKLACKTLTKDYPDGVIELMPMPAFRHIKDLSVNTGEWFEDMCKRVES
CHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
WVHNEKETDISKLEERIEPEVADETFELDRCIECGICVASCATKLMRPNFIAATGLLRTA
HHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RYLQDPHDHRSVEDFYELVGDDDGVFGCMSLLACEDNCPKELPLQSKIAYMRRQLVAQRN
HHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure 
SRKLTIKAFKYNPLSKISKPHFVTYELEETPFMTVFVCLTLIREKMDADLSFDFVCRAG
CCCEEEEEECCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCC
ICGSCAMMINGVPKLACKTLTKDYPDGVIELMPMPAFRHIKDLSVNTGEWFEDMCKRVES
CHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
WVHNEKETDISKLEERIEPEVADETFELDRCIECGICVASCATKLMRPNFIAATGLLRTA
HHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RYLQDPHDHRSVEDFYELVGDDDGVFGCMSLLACEDNCPKELPLQSKIAYMRRQLVAQRN
HHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]