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The map label for this gene is frdA [H]

Identifier: 57237464

GI number: 57237464

Start: 411039

End: 413030

Strand: Direct

Name: frdA [H]

Synonym: CJE0458

Alternate gene names: 57237464

Gene position: 411039-413030 (Clockwise)

Preceding gene: 57237463

Following gene: 57237465

Centisome position: 23.12

GC content: 37.85

Gene sequence:

>1992_bases
ATGAATATACAATATAGTGATGCTTTAGTAATAGGTGGAGGATTAGCAGGTCTTAGAGCGGCTATTGAAGTAGCAAAGAG
TGGCCAAAGTGTAACACTTTTAAGTATTTGTCCAGTGAAGCGTTCTCACTCTGCAGCGGTGCAAGGAGGTATGCAGGCAA
GTTTAGCAAATGGGGCAAAAGGTGAGGGTGATAATGAAGATCTTCACTTCGCAGATACAGTAAAAGGAAGTGATTGGGGC
TGTGATCAAGAAGTAGCAAGAATGTTTGCTCAAACTGCGCCAAAAGCAGTGCGTGAGCTTGCGGCTTGGGGTGTGCCTTG
GACTAGAGTTACTAAAGGTCCAAGAACTGTTGTAATCAATGCACAAAAAACTGTGATTGAAGAAAAAGAAGAAGCGCACG
GGCTTATTAATGCTAGAGATTTTGGTGGAACTAAAAAATGGAGAACTTGCTATATCGCAGATGCAACAGGGCATTGTATG
CTTTATGGTGTAGCAAATGAAGCTATTAAACATCAAGTAAAAATTATTGATAGAATGGAAGCAGTAAGAATTATCCATGA
TGGTAAAAAATGCTTAGGTGTGATTGCTAGAGATTTAACCAATGGACAACTCATTGCTTATATCGCAAGAGGAACTATGA
TAGCAACAGGGGGCTATGGTAGAATTTATAAACAAACTACAAATGCGGTAATTTGTGAAGGAACAGGTGCTGCTATCGCT
CTTGAAACGGGACTTTGTAGACTTTCAAATATGGAAGCAGTGCAATTTCACCCAACTCCTATTGTACCAAGCGGTATTTT
GCTTACTGAGGGCTGTCGTGGTGATGGTGGAATTTTACGTGACGTGGATGGATATCGTTTTATGCCTGATTATGAACCAG
AGAAAAAAGAACTTGCAAGCCGTGATGTGGTAAGTCGTAGAATGATGGAGCATATTCGCAAAGGTAAAGGTGTAAAAAGT
CCTTATGGGGATCATTTATGGCTTGATATTTCTATATTGGGTCGTGCTCATGTGGAAAAAAATCTCCGCGATGTACAAGA
TATTTGCAAAACTTTCAATGGTATTGATCCAGCAGATGAAGGTCCAAAAGGTTGGGCGCCAGTTCTTCCAATGCAGCATT
ATTCTATGGGTGGAATTAGAACTAAACCAACAGGTGAAAGTCAATGGTTAAACGGACTTTTTGCTTGTGGAGAAGCAGCT
TGCTGGGATATGCACGGATTTAATCGTTTAGGTGGAAATTCATGTGCTGAAACTGTTGTAGCAGGTATGATAGTGGGAGA
TTATTTTGCAGATTATTGTAAAAATAATGGTGAAGTAATTGACACAAATGTAGTAAAAGACTTCTTAACTAAAGAGTATC
AATATTTAAAATCTTTAGTAGATAAAGAAGGTAAATATAATGTTTTTGAAATTAAAAATAGAATGAAAGAAATTATGTGG
GATAAGGTGGCCATCTTTAGAACAGGTGAAGGTTTGAAAGAAGCAGTAGATGAACTTGAAAAACTTTATAAAGATTCTCA
AGATGTTAAAGTACATTGTAAAGAACTTGATTGTGCAAATCCAGAGCTTGAAGAAGCGTATAGAGTGCCAAGAATGTTAA
AAATAGCACTTTGCGTAGCTTATGGAGCGCTTTTAAGAACAGAAAGTCGTGGGGCGCATTATAGGGAAGATTATCCAAAA
AGAGATGATTTAAATTGGATGAAAAGAACCAATACTTTTTGGGTAGAAGGCGAAACCTTACCACGCATAGAATATGAAGA
GCTTGATATTATGAAAATGGAAATTCCACCAGCATTCCGTGGATATGGAGCTAAAGGAAATATTATAGAAAATCCTTTAA
GTGAAAAACGCCAAGCTGAAGTGGATGCAATACGTGAAAAAATGGAAGCTGAAGGCAAAGGTCGTTATGAAATTCAAAAC
GCTTTAATGCCTTATGAATTACAAGCTAAATATAAAGCACCAAACCAAAGAATAGGAGTTGATTATGAGTAG

Upstream 100 bases:

>100_bases
GGTGTGTTAAGTCTTGCAGCATTTATAAAAATAGGTTATGAAAACTACCAAAATCAAACCCAAACTACTGCGATGATAAA
AAACTACAATGGAGCAAATT

Downstream 100 bases:

>100_bases
AAAATTGACAATAAAGGCATTTAAATATAATCCTTTAAGCAAAATTTCTAAACCACATTTTGTGACTTATGAGCTTGAAG
AAACTCCTTTTATGACGGTT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MNIQYSDALVIGGGLAGLRAAIEVAKSGQSVTLLSICPVKRSHSAAVQGGMQASLANGAKGEGDNEDLHFADTVKGSDWG
CDQEVARMFAQTAPKAVRELAAWGVPWTRVTKGPRTVVINAQKTVIEEKEEAHGLINARDFGGTKKWRTCYIADATGHCM
LYGVANEAIKHQVKIIDRMEAVRIIHDGKKCLGVIARDLTNGQLIAYIARGTMIATGGYGRIYKQTTNAVICEGTGAAIA
LETGLCRLSNMEAVQFHPTPIVPSGILLTEGCRGDGGILRDVDGYRFMPDYEPEKKELASRDVVSRRMMEHIRKGKGVKS
PYGDHLWLDISILGRAHVEKNLRDVQDICKTFNGIDPADEGPKGWAPVLPMQHYSMGGIRTKPTGESQWLNGLFACGEAA
CWDMHGFNRLGGNSCAETVVAGMIVGDYFADYCKNNGEVIDTNVVKDFLTKEYQYLKSLVDKEGKYNVFEIKNRMKEIMW
DKVAIFRTGEGLKEAVDELEKLYKDSQDVKVHCKELDCANPELEEAYRVPRMLKIALCVAYGALLRTESRGAHYREDYPK
RDDLNWMKRTNTFWVEGETLPRIEYEELDIMKMEIPPAFRGYGAKGNIIENPLSEKRQAEVDAIREKMEAEGKGRYEIQN
ALMPYELQAKYKAPNQRIGVDYE

Sequences:

>Translated_663_residues
MNIQYSDALVIGGGLAGLRAAIEVAKSGQSVTLLSICPVKRSHSAAVQGGMQASLANGAKGEGDNEDLHFADTVKGSDWG
CDQEVARMFAQTAPKAVRELAAWGVPWTRVTKGPRTVVINAQKTVIEEKEEAHGLINARDFGGTKKWRTCYIADATGHCM
LYGVANEAIKHQVKIIDRMEAVRIIHDGKKCLGVIARDLTNGQLIAYIARGTMIATGGYGRIYKQTTNAVICEGTGAAIA
LETGLCRLSNMEAVQFHPTPIVPSGILLTEGCRGDGGILRDVDGYRFMPDYEPEKKELASRDVVSRRMMEHIRKGKGVKS
PYGDHLWLDISILGRAHVEKNLRDVQDICKTFNGIDPADEGPKGWAPVLPMQHYSMGGIRTKPTGESQWLNGLFACGEAA
CWDMHGFNRLGGNSCAETVVAGMIVGDYFADYCKNNGEVIDTNVVKDFLTKEYQYLKSLVDKEGKYNVFEIKNRMKEIMW
DKVAIFRTGEGLKEAVDELEKLYKDSQDVKVHCKELDCANPELEEAYRVPRMLKIALCVAYGALLRTESRGAHYREDYPK
RDDLNWMKRTNTFWVEGETLPRIEYEELDIMKMEIPPAFRGYGAKGNIIENPLSEKRQAEVDAIREKMEAEGKGRYEIQN
ALMPYELQAKYKAPNQRIGVDYE
>Mature_663_residues
MNIQYSDALVIGGGLAGLRAAIEVAKSGQSVTLLSICPVKRSHSAAVQGGMQASLANGAKGEGDNEDLHFADTVKGSDWG
CDQEVARMFAQTAPKAVRELAAWGVPWTRVTKGPRTVVINAQKTVIEEKEEAHGLINARDFGGTKKWRTCYIADATGHCM
LYGVANEAIKHQVKIIDRMEAVRIIHDGKKCLGVIARDLTNGQLIAYIARGTMIATGGYGRIYKQTTNAVICEGTGAAIA
LETGLCRLSNMEAVQFHPTPIVPSGILLTEGCRGDGGILRDVDGYRFMPDYEPEKKELASRDVVSRRMMEHIRKGKGVKS
PYGDHLWLDISILGRAHVEKNLRDVQDICKTFNGIDPADEGPKGWAPVLPMQHYSMGGIRTKPTGESQWLNGLFACGEAA
CWDMHGFNRLGGNSCAETVVAGMIVGDYFADYCKNNGEVIDTNVVKDFLTKEYQYLKSLVDKEGKYNVFEIKNRMKEIMW
DKVAIFRTGEGLKEAVDELEKLYKDSQDVKVHCKELDCANPELEEAYRVPRMLKIALCVAYGALLRTESRGAHYREDYPK
RDDLNWMKRTNTFWVEGETLPRIEYEELDIMKMEIPPAFRGYGAKGNIIENPLSEKRQAEVDAIREKMEAEGKGRYEIQN
ALMPYELQAKYKAPNQRIGVDYE

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=596, Percent_Identity=34.8993288590604, Blast_Score=306, Evalue=6e-83,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=34.923339011925, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1786942, Length=613, Percent_Identity=34.257748776509, Blast_Score=315, Evalue=7e-87,
Organism=Escherichia coli, GI1788928, Length=566, Percent_Identity=28.7985865724382, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=35.8181818181818, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17550100, Length=566, Percent_Identity=35.5123674911661, Blast_Score=298, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6322416, Length=616, Percent_Identity=37.3376623376623, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6322701, Length=621, Percent_Identity=36.8760064412238, Blast_Score=331, Evalue=2e-91,
Organism=Drosophila melanogaster, GI17137288, Length=620, Percent_Identity=33.0645161290323, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24655642, Length=620, Percent_Identity=33.0645161290323, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24655647, Length=620, Percent_Identity=33.0645161290323, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24663005, Length=639, Percent_Identity=32.8638497652582, Blast_Score=271, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73815; Mature: 73815

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQYSDALVIGGGLAGLRAAIEVAKSGQSVTLLSICPVKRSHSAAVQGGMQASLANGAK
CCCEECCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCHHHHCCCCC
GEGDNEDLHFADTVKGSDWGCDQEVARMFAQTAPKAVRELAAWGVPWTRVTKGPRTVVIN
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEE
AQKTVIEEKEEAHGLINARDFGGTKKWRTCYIADATGHCMLYGVANEAIKHQVKIIDRME
CHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHH
AVRIIHDGKKCLGVIARDLTNGQLIAYIARGTMIATGGYGRIYKQTTNAVICEGTGAAIA
HHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEEEECCCEEEECCCCCEEE
LETGLCRLSNMEAVQFHPTPIVPSGILLTEGCRGDGGILRDVDGYRFMPDYEPEKKELAS
EECCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHH
RDVVSRRMMEHIRKGKGVKSPYGDHLWLDISILGRAHVEKNLRDVQDICKTFNGIDPADE
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GPKGWAPVLPMQHYSMGGIRTKPTGESQWLNGLFACGEAACWDMHGFNRLGGNSCAETVV
CCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCHHEECCCCCCCCCCCHHHHHHH
AGMIVGDYFADYCKNNGEVIDTNVVKDFLTKEYQYLKSLVDKEGKYNVFEIKNRMKEIMW
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DKVAIFRTGEGLKEAVDELEKLYKDSQDVKVHCKELDCANPELEEAYRVPRMLKIALCVA
HHHEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHH
YGALLRTESRGAHYREDYPKRDDLNWMKRTNTFWVEGETLPRIEYEELDIMKMEIPPAFR
HHHHHHCCCCCCCCHHCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCCEEEEECCCHHC
GYGAKGNIIENPLSEKRQAEVDAIREKMEAEGKGRYEIQNALMPYELQAKYKAPNQRIGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCEEEEEEECCCCCCCCC
DYE
CCC
>Mature Secondary Structure
MNIQYSDALVIGGGLAGLRAAIEVAKSGQSVTLLSICPVKRSHSAAVQGGMQASLANGAK
CCCEECCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCHHHHCCCCC
GEGDNEDLHFADTVKGSDWGCDQEVARMFAQTAPKAVRELAAWGVPWTRVTKGPRTVVIN
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEE
AQKTVIEEKEEAHGLINARDFGGTKKWRTCYIADATGHCMLYGVANEAIKHQVKIIDRME
CHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHH
AVRIIHDGKKCLGVIARDLTNGQLIAYIARGTMIATGGYGRIYKQTTNAVICEGTGAAIA
HHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEEEECCCEEEECCCCCEEE
LETGLCRLSNMEAVQFHPTPIVPSGILLTEGCRGDGGILRDVDGYRFMPDYEPEKKELAS
EECCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHH
RDVVSRRMMEHIRKGKGVKSPYGDHLWLDISILGRAHVEKNLRDVQDICKTFNGIDPADE
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GPKGWAPVLPMQHYSMGGIRTKPTGESQWLNGLFACGEAACWDMHGFNRLGGNSCAETVV
CCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCHHEECCCCCCCCCCCHHHHHHH
AGMIVGDYFADYCKNNGEVIDTNVVKDFLTKEYQYLKSLVDKEGKYNVFEIKNRMKEIMW
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DKVAIFRTGEGLKEAVDELEKLYKDSQDVKVHCKELDCANPELEEAYRVPRMLKIALCVA
HHHEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHH
YGALLRTESRGAHYREDYPKRDDLNWMKRTNTFWVEGETLPRIEYEELDIMKMEIPPAFR
HHHHHHCCCCCCCCHHCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCCEEEEECCCHHC
GYGAKGNIIENPLSEKRQAEVDAIREKMEAEGKGRYEIQNALMPYELQAKYKAPNQRIGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCEEEEEEECCCCCCCCC
DYE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]