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The map label for this gene is pncB [H]

Identifier: 57237290

GI number: 57237290

Start: 249316

End: 250686

Strand: Reverse

Name: pncB [H]

Synonym: CJE0281

Alternate gene names: 57237290

Gene position: 250686-249316 (Counterclockwise)

Preceding gene: 57237291

Following gene: 57237288

Centisome position: 14.1

GC content: 30.27

Gene sequence:

>1371_bases
ATGACTTCTAAAACTTCTTTAGCCTTACTTTGTGATTTTTATGAATTTACAATGTCTCAAGGCTATTTCAAAAACAATAA
AAAAGATCAAATTTGTTATTTTGATATATTTTTTAGAAAAATTCCAGATTCAGGTTCTTTTGCTATTTTTGCAGGTCTTG
AAGATATTTTAGACTTTGTTGAAAATTTGAGTTTTGATACAGAAGATATAGAATTTTTAAGAAAACAAGGTATTTTTGAT
ACAAAATTTTTAGATTTTTTAGCTAACTTTAAATTTAAGGGTGAAATTTATGCTATGCGTGAAGGAGAAGTGATTTTTCC
AAACGAACCTTTACTTTGCGTTAAAGCTACAACCATAGAAGCACAGCTTTTAGAAACTTTTTTACTTTTAAGTTTAAACC
ACCAAAGCCTTATTGCTACCAAAACCAATCGTATCGTGCGTGCAGCTAAAGACAGTAAAATTTTAGAATTTGGTTCACGC
AGAGCACAAGGAAGTGAAGCAGCCTTAAAAGGAGCAAGAGCAGCTTTTATAGGAGGTTGCATAGGAAGTGCTTGTACTTT
AGCAGGAAAAATTTATAATATCCCTATCAATGGAACTATGGCACATTCTTGGGTGCAAATGTTTGAAAATGAACTTGAAG
CTTTTAAAGCTTATGTGAAAATTTATCCAAAAAATCCTGTTTTTTTGATTGATACTTATGATTGTCTAAATAGCGGACTT
AAAAATGCGATTAAAGTTTTTAAAGAATTTGGTATTCAAGAAGGCGGCGTGAGAATAGATTCTGGAAATTTACTTAAGTT
GAGTTTGAAAATCAGACAAGAACTTGATCAAGCAGGACTTCAAAAATGTAAAATCATAGTTTCTAACGCACTTGATGAAT
GGAGCATTAAAAAACTCAAAGAACAAAATGCACCTATTGATATCTTTGGTGTAGGTGAAAGATTGATCACTGCTTCAAGT
GACCCTATTTTTAGTTGCGTTTATAAACTCGCAGCCTTAGAAGATCAAGGCATAAAACCTAAAATCAAAATCAGCGAAAA
TAACGAAAAATTAACCCTACCTCATTTTAAAAAGCTTTTTAGGGTTTATGATAAAAACACGCAAAAAATCCTTTTTGATG
AACTTTATGTTTTTGACGAAAACCCAAATCAAGATGAAAATTTAGAACGCAAAGAACTTTTAGAATTAGTCTACAAAGAA
AAAAGACTTCTTAAAAAGTCATCTTTAAATACTATTCAAGATTATACAAAAGAGCAAATTTCAAAACTCGATGAGAGTTT
TTTAGATCTTGATCGTTTTGTGAAATTTGAAGTAAAACTCTCGCCTAAACTTCAAAATATCACTGAAGATCTTTTAAAAA
CTCGTTTTTAA

Upstream 100 bases:

>100_bases
CCTATTAAATGGGTAGATGATTTTTCAAAATTTAACGATCAAAAGAGCAATTTCTTTGAAAGTAAAGTAACGAATTATTC
TAAGGGTAGTATAAGCTTTG

Downstream 100 bases:

>100_bases
AATCCACATAATTTAAAGCGGATTGTTTTAGAAAGCTGACTTCTTCATCGTTTAATTCACGCACAAATTTTGCAGGATTT
CCAAGTATCAAAGAGCGTGG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTSKTSLALLCDFYEFTMSQGYFKNNKKDQICYFDIFFRKIPDSGSFAIFAGLEDILDFVENLSFDTEDIEFLRKQGIFD
TKFLDFLANFKFKGEIYAMREGEVIFPNEPLLCVKATTIEAQLLETFLLLSLNHQSLIATKTNRIVRAAKDSKILEFGSR
RAQGSEAALKGARAAFIGGCIGSACTLAGKIYNIPINGTMAHSWVQMFENELEAFKAYVKIYPKNPVFLIDTYDCLNSGL
KNAIKVFKEFGIQEGGVRIDSGNLLKLSLKIRQELDQAGLQKCKIIVSNALDEWSIKKLKEQNAPIDIFGVGERLITASS
DPIFSCVYKLAALEDQGIKPKIKISENNEKLTLPHFKKLFRVYDKNTQKILFDELYVFDENPNQDENLERKELLELVYKE
KRLLKKSSLNTIQDYTKEQISKLDESFLDLDRFVKFEVKLSPKLQNITEDLLKTRF

Sequences:

>Translated_456_residues
MTSKTSLALLCDFYEFTMSQGYFKNNKKDQICYFDIFFRKIPDSGSFAIFAGLEDILDFVENLSFDTEDIEFLRKQGIFD
TKFLDFLANFKFKGEIYAMREGEVIFPNEPLLCVKATTIEAQLLETFLLLSLNHQSLIATKTNRIVRAAKDSKILEFGSR
RAQGSEAALKGARAAFIGGCIGSACTLAGKIYNIPINGTMAHSWVQMFENELEAFKAYVKIYPKNPVFLIDTYDCLNSGL
KNAIKVFKEFGIQEGGVRIDSGNLLKLSLKIRQELDQAGLQKCKIIVSNALDEWSIKKLKEQNAPIDIFGVGERLITASS
DPIFSCVYKLAALEDQGIKPKIKISENNEKLTLPHFKKLFRVYDKNTQKILFDELYVFDENPNQDENLERKELLELVYKE
KRLLKKSSLNTIQDYTKEQISKLDESFLDLDRFVKFEVKLSPKLQNITEDLLKTRF
>Mature_455_residues
TSKTSLALLCDFYEFTMSQGYFKNNKKDQICYFDIFFRKIPDSGSFAIFAGLEDILDFVENLSFDTEDIEFLRKQGIFDT
KFLDFLANFKFKGEIYAMREGEVIFPNEPLLCVKATTIEAQLLETFLLLSLNHQSLIATKTNRIVRAAKDSKILEFGSRR
AQGSEAALKGARAAFIGGCIGSACTLAGKIYNIPINGTMAHSWVQMFENELEAFKAYVKIYPKNPVFLIDTYDCLNSGLK
NAIKVFKEFGIQEGGVRIDSGNLLKLSLKIRQELDQAGLQKCKIIVSNALDEWSIKKLKEQNAPIDIFGVGERLITASSD
PIFSCVYKLAALEDQGIKPKIKISENNEKLTLPHFKKLFRVYDKNTQKILFDELYVFDENPNQDENLERKELLELVYKEK
RLLKKSSLNTIQDYTKEQISKLDESFLDLDRFVKFEVKLSPKLQNITEDLLKTRF

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=520, Percent_Identity=28.6538461538462, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71997947, Length=452, Percent_Identity=34.9557522123894, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71997952, Length=452, Percent_Identity=34.9557522123894, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71997955, Length=220, Percent_Identity=40.9090909090909, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24581587, Length=434, Percent_Identity=34.7926267281106, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI161076680, Length=207, Percent_Identity=41.0628019323672, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24581595, Length=207, Percent_Identity=41.0628019323672, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574709, Length=207, Percent_Identity=41.0628019323672, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24581593, Length=207, Percent_Identity=41.0628019323672, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24581591, Length=207, Percent_Identity=41.0628019323672, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 52173; Mature: 52042

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKTSLALLCDFYEFTMSQGYFKNNKKDQICYFDIFFRKIPDSGSFAIFAGLEDILDFV
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHCCCCCCEEEECCHHHHHHHH
ENLSFDTEDIEFLRKQGIFDTKFLDFLANFKFKGEIYAMREGEVIFPNEPLLCVKATTIE
HHCCCCHHHHHHHHHCCCCHHHHHHHHHCCEECCEEEEEECCCEECCCCCEEEEEECHHH
AQLLETFLLLSLNHQSLIATKTNRIVRAAKDSKILEFGSRRAQGSEAALKGARAAFIGGC
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCHHHHHHHH
IGSACTLAGKIYNIPINGTMAHSWVQMFENELEAFKAYVKIYPKNPVFLIDTYDCLNSGL
HHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECHHHHHHHH
KNAIKVFKEFGIQEGGVRIDSGNLLKLSLKIRQELDQAGLQKCKIIVSNALDEWSIKKLK
HHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EQNAPIDIFGVGERLITASSDPIFSCVYKLAALEDQGIKPKIKISENNEKLTLPHFKKLF
HCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECHHHHHHH
RVYDKNTQKILFDELYVFDENPNQDENLERKELLELVYKEKRLLKKSSLNTIQDYTKEQI
HHHCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SKLDESFLDLDRFVKFEVKLSPKLQNITEDLLKTRF
HHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSKTSLALLCDFYEFTMSQGYFKNNKKDQICYFDIFFRKIPDSGSFAIFAGLEDILDFV
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHCCCCCCEEEECCHHHHHHHH
ENLSFDTEDIEFLRKQGIFDTKFLDFLANFKFKGEIYAMREGEVIFPNEPLLCVKATTIE
HHCCCCHHHHHHHHHCCCCHHHHHHHHHCCEECCEEEEEECCCEECCCCCEEEEEECHHH
AQLLETFLLLSLNHQSLIATKTNRIVRAAKDSKILEFGSRRAQGSEAALKGARAAFIGGC
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCHHHHHHHH
IGSACTLAGKIYNIPINGTMAHSWVQMFENELEAFKAYVKIYPKNPVFLIDTYDCLNSGL
HHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECHHHHHHHH
KNAIKVFKEFGIQEGGVRIDSGNLLKLSLKIRQELDQAGLQKCKIIVSNALDEWSIKKLK
HHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EQNAPIDIFGVGERLITASSDPIFSCVYKLAALEDQGIKPKIKISENNEKLTLPHFKKLF
HCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECHHHHHHH
RVYDKNTQKILFDELYVFDENPNQDENLERKELLELVYKEKRLLKKSSLNTIQDYTKEQI
HHHCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SKLDESFLDLDRFVKFEVKLSPKLQNITEDLLKTRF
HHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]