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The map label for this gene is adk [H]

Identifier: 57236952

GI number: 57236952

Start: 676917

End: 677495

Strand: Reverse

Name: adk [H]

Synonym: CJE0742

Alternate gene names: 57236952

Gene position: 677495-676917 (Counterclockwise)

Preceding gene: 57236953

Following gene: 57236951

Centisome position: 38.11

GC content: 34.02

Gene sequence:

>579_bases
ATGAAAGAATTGTTTTTAATCATAGGTGCACCAGGTAGTGGAAAAACTACCGATGCTAGTTTAATCGCACAAGCAGATGC
GACAAATATTACACACTATTCAACAGGAGATCTTTTAAGAGCTGAAGTAGCAAGTGGGAGCGAGCTTGGAAAAACTATAG
ATAGTTTTATCTCCAAAGGCAATCTTGTTCCTTTAGATGTTGTTATAAATACTATAGTTTGTGCTCTAAAAGCTGCTCCA
ACTAAAACTATCATCATCGATGGCTATCCAAGAAGCGTAGAGCAAATGATGGAATTTGATAAGGTTTTAAGTGAGCAAAA
TGAAATTTGTCTTAAAGGCGTCATAGAAGTAAGAGTAAGCGAAGAAGTTGCCAAAGAAAGAGTTTTAGGCAGAAATCGCG
GCACAGATGATAATGAAGAAGTGTTTTACAATAGAATGAAAGTTTATACAGAACCTTTAAATGAAATTTTAGATTTTTAT
CAAAAGAAAAAACTTCATTTTATTATCGATGGAGAGCGCGCTATCGAACCTATCGTTGCAGACATGAAAGAACTGATTAA
AAAAATTCAAAGTATATAA

Upstream 100 bases:

>100_bases
CAAAAACCCAAAGAGCGCAATGCTTAATGACAGATGCACCATCGCCTGCTAGCAATGAAGCAATGAGAGAATTAGGAATC
AAATTAAGGGAGAATATAAA

Downstream 100 bases:

>100_bases
GGAGAAAAAATGAATTTAAACAAAATCAAAATCGGAGATATTCCAAATAAAATCAATGCCGTAATTGAAATTCCATATGG
CTCAAATATAAAATACGAAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAEVASGSELGKTIDSFISKGNLVPLDVVINTIVCALKAAP
TKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKERVLGRNRGTDDNEEVFYNRMKVYTEPLNEILDFY
QKKKLHFIIDGERAIEPIVADMKELIKKIQSI

Sequences:

>Translated_192_residues
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAEVASGSELGKTIDSFISKGNLVPLDVVINTIVCALKAAP
TKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKERVLGRNRGTDDNEEVFYNRMKVYTEPLNEILDFY
QKKKLHFIIDGERAIEPIVADMKELIKKIQSI
>Mature_192_residues
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAEVASGSELGKTIDSFISKGNLVPLDVVINTIVCALKAAP
TKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKERVLGRNRGTDDNEEVFYNRMKVYTEPLNEILDFY
QKKKLHFIIDGERAIEPIVADMKELIKKIQSI

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=185, Percent_Identity=32.972972972973, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI7524346, Length=217, Percent_Identity=28.110599078341, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=28.3653846153846, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI28144897, Length=173, Percent_Identity=34.1040462427746, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=173, Percent_Identity=34.1040462427746, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706497, Length=193, Percent_Identity=25.9067357512953, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=25.3456221198157, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567503, Length=183, Percent_Identity=34.4262295081967, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=30.6976744186047, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=189, Percent_Identity=31.2169312169312, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=30.5, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=29.5698924731183, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=27.1428571428571, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=28.2828282828283, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=27.8947368421053, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=199, Percent_Identity=29.6482412060301, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24663208, Length=190, Percent_Identity=31.5789473684211, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17647141, Length=190, Percent_Identity=31.5789473684211, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221459597, Length=164, Percent_Identity=32.3170731707317, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356893, Length=164, Percent_Identity=32.3170731707317, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=29.5238095238095, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=29.5238095238095, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21348; Mature: 21348

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAEVASGSELGKTIDSFISKG
CCEEEEEEECCCCCCCCCHHHHEECCCCCCCEECCCCHHHHHHHCCHHHHHHHHHHHHCC
NLVPLDVVINTIVCALKAAPTKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVS
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EEVAKERVLGRNRGTDDNEEVFYNRMKVYTEPLNEILDFYQKKKLHFIIDGERAIEPIVA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
DMKELIKKIQSI
HHHHHHHHHHCC
>Mature Secondary Structure
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAEVASGSELGKTIDSFISKG
CCEEEEEEECCCCCCCCCHHHHEECCCCCCCEECCCCHHHHHHHCCHHHHHHHHHHHHCC
NLVPLDVVINTIVCALKAAPTKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVS
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EEVAKERVLGRNRGTDDNEEVFYNRMKVYTEPLNEILDFYQKKKLHFIIDGERAIEPIVA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
DMKELIKKIQSI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA