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The map label for this gene is msrA [H]

Identifier: 57236950

GI number: 57236950

Start: 675850

End: 676347

Strand: Reverse

Name: msrA [H]

Synonym: CJE0740

Alternate gene names: 57236950

Gene position: 676347-675850 (Counterclockwise)

Preceding gene: 57236951

Following gene: 57236944

Centisome position: 38.04

GC content: 28.92

Gene sequence:

>498_bases
ATGAAAAATATCATTTTAGGTGGTGGTTGTTTTTGGTGTATTGAAGCCGTATTTGAACGTCTAAAAGGTGTAATCAATAC
TGAAGTTGGATATAGCGGAGGAAAACCAAATCCTAGCTATGAAAGCGTGTGTAATGGTGATGGTAACATAGAAGTTGTCA
AAATAAATTACGATGAAAAACAAATCTCTCTTCTTGAAATCCTAATACTCTTTTTTAAAATTCATGATCCAACAAGTATA
GATAAACAAGGTGAAGATATTGGCATACAATATCGCTCAATAATATTTTACGAAAATGAAGAAGATAAAATTTTAGCTCA
AAATTTCATTGAAGAACAGCAAAAAATATTTAGTAAAAAAATAGTTACTAAAATTTCAAGATTGCAAACTTACTATAAAG
CTGAAAACTATCATCAACATTATTTTATAAATAATCCCGATCAAGGATATTGTCAAGCTGTAATAGCTCCAAAACTGCAA
AAAATACAATCAGACTAA

Upstream 100 bases:

>100_bases
TCAAAGATGAAAAAGCCGCAATTGAAATTTTAGAAAAAGCAATCAAAAACTATAAATAATCTTAGCCCTTTCAAAGGGCT
AAGATTAAGGAAAACTCGCA

Downstream 100 bases:

>100_bases
TTTCATCTTTTTAAGGTTAAAAAAAATTCAACTTTATTCACAGCCTTTTCACGCTGTGATTTTCTTTTCAAAGTACTTAA
AAATAGAACTTTAAGCTTTA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKNIILGGGCFWCIEAVFERLKGVINTEVGYSGGKPNPSYESVCNGDGNIEVVKINYDEKQISLLEILILFFKIHDPTSI
DKQGEDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKKIVTKISRLQTYYKAENYHQHYFINNPDQGYCQAVIAPKLQ
KIQSD

Sequences:

>Translated_165_residues
MKNIILGGGCFWCIEAVFERLKGVINTEVGYSGGKPNPSYESVCNGDGNIEVVKINYDEKQISLLEILILFFKIHDPTSI
DKQGEDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKKIVTKISRLQTYYKAENYHQHYFINNPDQGYCQAVIAPKLQ
KIQSD
>Mature_165_residues
MKNIILGGGCFWCIEAVFERLKGVINTEVGYSGGKPNPSYESVCNGDGNIEVVKINYDEKQISLLEILILFFKIHDPTSI
DKQGEDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKKIVTKISRLQTYYKAENYHQHYFINNPDQGYCQAVIAPKLQ
KIQSD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=42.483660130719, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=42.483660130719, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI208609993, Length=120, Percent_Identity=38.3333333333333, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=39.8692810457516, Blast_Score=115, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=35.8108108108108, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=39.622641509434, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24664627, Length=160, Percent_Identity=35.625, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45553131, Length=156, Percent_Identity=35.8974358974359, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=159, Percent_Identity=34.5911949685535, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19009; Mature: 19009

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIILGGGCFWCIEAVFERLKGVINTEVGYSGGKPNPSYESVCNGDGNIEVVKINYDEK
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCHH
QISLLEILILFFKIHDPTSIDKQGEDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IVTKISRLQTYYKAENYHQHYFINNPDQGYCQAVIAPKLQKIQSD
HHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNIILGGGCFWCIEAVFERLKGVINTEVGYSGGKPNPSYESVCNGDGNIEVVKINYDEK
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCHH
QISLLEILILFFKIHDPTSIDKQGEDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IVTKISRLQTYYKAENYHQHYFINNPDQGYCQAVIAPKLQKIQSD
HHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA