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The map label for this gene is argH [H]

Identifier: 21228409

GI number: 21228409

Start: 2762194

End: 2763669

Strand: Reverse

Name: argH [H]

Synonym: MM_2307

Alternate gene names: 21228409

Gene position: 2763669-2762194 (Counterclockwise)

Preceding gene: 21228411

Following gene: 21228408

Centisome position: 67.47

GC content: 46.95

Gene sequence:

>1476_bases
ATGAGCAATATTTTAAGGAGAGGCAGGCTTGAAGCTGCCCAGGATGAGGAAATTTTACGCTACACCTCCTCTATGGAGGC
CGACCGATGGATATTTAATGCCGACATAGTGGTTGACCTTGCCCATACGGTAATGCTGAGAGAGCAGGGCATTATAAAAG
AAGAAGATTGCAGCAAAATCCTCAGCGGGCTTTTAAAGATAAGGGAAGAAGGCATGGAAAAGCTCGACTTCAGCTATGAA
GACATACACATCTCGCTTGAATCCAGGCTCATCGACATGGTAGGAGAGGATGTGGGAGGCAGGATGCACTCCGGGCGTTC
AAGAAACGATGAGGTTGCAACCTGCATCAGGCTGACTCTCAGGGAAGAACTTCTCGGGCTGCTTGAAGAAATATTTGCAT
TAAGAAAAACTCTTGTCAGCCTCGCAGAAAAACACAGTGAAACCCTTATGCCTGGCTTTACCCATCTCCAGCACGCCCAG
CCGACCACTCTGGCTCACCACCTCTGTGCACACGAATCTGCTCTAGGCAGGGATTTTGACAGGGTGCAGGACGCTTTTTC
ACGGGTCAACCTCTGCCCGCTTGGGGCTGCTGCATTTGCATCTACCGGCTTTAACCTCAACAGGAAAAGGACTCAGGAAC
TCCTGGGCTTTGAAGGGCTTCTGGAGAATTCTATGGATGCAGTCAGCAGCAGGGATTTCCTTATCGAATGCGCCTCTGTG
TTTTCGAATCTCATGATAAACCTCAGCAGAATAGCTGAAGAACTTGTAATCTGGTCTTCATCAGAGTTCAATTTCATTGA
GCTTGACGATATGTATGCTTCCACTTCTTCGATTATGCCCCAGAAGAAAAACCCGGATACTGCGGAATTAATGCGCGGAA
AAACAGGAGTTTCTGTGGGCGCCCTTATGTCCCTGCTCACGATCTGTAAAGGCCTGCCCCTGAGTTACAATCGCGACCTG
CAGGAAGCAACACCCAATATCTGGCGCTCGGTTGAAACTGTAAGGGCTTCTGTCAGGGTAATGGAAGGAATGGTCAAAAC
CATGAAAGTCCATCCCGACGTGCTCGCAGCCGAATCAATAACGGGTTTTACAACAGCTACCGAACTTGCGGATACCTTTG
TCAGGGAAACAGGAATCCCCTTCAGGACTGCCCACCAGATAGTAGGAATGCTTGCAAAGGAAAGGGAAAAGCCAACAATG
GAAAAGATAGACTCTGCATCTGAGGTTGTTCTCGGGGAGTCGCTTTCAAGCAAAGGATTAACAGAAAATATGGTAAAGGA
AGCTCTCAATCCTGAATCCAATATAAAAAGAAGAAAAATTCCTGGAGGCCCTGCTCCTGAGGAAATGAAAAATTATCTAT
CAAAAAGGAAGACTGAGCTTGAACTGAACGCACAGGAAATTGCAACCCTGAAAGATATAATAGACTCGGCTTTTGAAAAT
CTGCTTTCAGTGGTTGAAGAATACAGAAAAATCTGA

Upstream 100 bases:

>100_bases
TATTTAAGCCGTTATTACACATTTAAAATAGATATTCTCACAACATATAATATTCACAATTAGATAGAGGACATATTTAA
AATTATACAGAGGACACCCG

Downstream 100 bases:

>100_bases
GTGCGGTGGTTTTAAGCGCAGAAAACACGTTTAATTTTAATATTATTTCAGACCTTTTAGTATTGCACAGATTATACAGA
ATAAAACTGCATCATCGGAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSNILRRGRLEAAQDEEILRYTSSMEADRWIFNADIVVDLAHTVMLREQGIIKEEDCSKILSGLLKIREEGMEKLDFSYE
DIHISLESRLIDMVGEDVGGRMHSGRSRNDEVATCIRLTLREELLGLLEEIFALRKTLVSLAEKHSETLMPGFTHLQHAQ
PTTLAHHLCAHESALGRDFDRVQDAFSRVNLCPLGAAAFASTGFNLNRKRTQELLGFEGLLENSMDAVSSRDFLIECASV
FSNLMINLSRIAEELVIWSSSEFNFIELDDMYASTSSIMPQKKNPDTAELMRGKTGVSVGALMSLLTICKGLPLSYNRDL
QEATPNIWRSVETVRASVRVMEGMVKTMKVHPDVLAAESITGFTTATELADTFVRETGIPFRTAHQIVGMLAKEREKPTM
EKIDSASEVVLGESLSSKGLTENMVKEALNPESNIKRRKIPGGPAPEEMKNYLSKRKTELELNAQEIATLKDIIDSAFEN
LLSVVEEYRKI

Sequences:

>Translated_491_residues
MSNILRRGRLEAAQDEEILRYTSSMEADRWIFNADIVVDLAHTVMLREQGIIKEEDCSKILSGLLKIREEGMEKLDFSYE
DIHISLESRLIDMVGEDVGGRMHSGRSRNDEVATCIRLTLREELLGLLEEIFALRKTLVSLAEKHSETLMPGFTHLQHAQ
PTTLAHHLCAHESALGRDFDRVQDAFSRVNLCPLGAAAFASTGFNLNRKRTQELLGFEGLLENSMDAVSSRDFLIECASV
FSNLMINLSRIAEELVIWSSSEFNFIELDDMYASTSSIMPQKKNPDTAELMRGKTGVSVGALMSLLTICKGLPLSYNRDL
QEATPNIWRSVETVRASVRVMEGMVKTMKVHPDVLAAESITGFTTATELADTFVRETGIPFRTAHQIVGMLAKEREKPTM
EKIDSASEVVLGESLSSKGLTENMVKEALNPESNIKRRKIPGGPAPEEMKNYLSKRKTELELNAQEIATLKDIIDSAFEN
LLSVVEEYRKI
>Mature_490_residues
SNILRRGRLEAAQDEEILRYTSSMEADRWIFNADIVVDLAHTVMLREQGIIKEEDCSKILSGLLKIREEGMEKLDFSYED
IHISLESRLIDMVGEDVGGRMHSGRSRNDEVATCIRLTLREELLGLLEEIFALRKTLVSLAEKHSETLMPGFTHLQHAQP
TTLAHHLCAHESALGRDFDRVQDAFSRVNLCPLGAAAFASTGFNLNRKRTQELLGFEGLLENSMDAVSSRDFLIECASVF
SNLMINLSRIAEELVIWSSSEFNFIELDDMYASTSSIMPQKKNPDTAELMRGKTGVSVGALMSLLTICKGLPLSYNRDLQ
EATPNIWRSVETVRASVRVMEGMVKTMKVHPDVLAAESITGFTTATELADTFVRETGIPFRTAHQIVGMLAKEREKPTME
KIDSASEVVLGESLSSKGLTENMVKEALNPESNIKRRKIPGGPAPEEMKNYLSKRKTELELNAQEIATLKDIIDSAFENL
LSVVEEYRKI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=391, Percent_Identity=37.8516624040921, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI68303542, Length=391, Percent_Identity=37.8516624040921, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI68303547, Length=391, Percent_Identity=35.5498721227622, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI68303549, Length=391, Percent_Identity=35.0383631713555, Blast_Score=231, Evalue=2e-60,
Organism=Escherichia coli, GI1790398, Length=462, Percent_Identity=35.0649350649351, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=34.4902386117137, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI221473854, Length=441, Percent_Identity=33.7868480725624, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI78706858, Length=441, Percent_Identity=33.7868480725624, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54947; Mature: 54815

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNILRRGRLEAAQDEEILRYTSSMEADRWIFNADIVVDLAHTVMLREQGIIKEEDCSKI
CCCHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCHHHHHHH
LSGLLKIREEGMEKLDFSYEDIHISLESRLIDMVGEDVGGRMHSGRSRNDEVATCIRLTL
HHHHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
REELLGLLEEIFALRKTLVSLAEKHSETLMPGFTHLQHAQPTTLAHHLCAHESALGRDFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHH
RVQDAFSRVNLCPLGAAAFASTGFNLNRKRTQELLGFEGLLENSMDAVSSRDFLIECASV
HHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSNLMINLSRIAEELVIWSSSEFNFIELDDMYASTSSIMPQKKNPDTAELMRGKTGVSVG
HHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHH
ALMSLLTICKGLPLSYNRDLQEATPNIWRSVETVRASVRVMEGMVKTMKVHPDVLAAESI
HHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TGFTTATELADTFVRETGIPFRTAHQIVGMLAKEREKPTMEKIDSASEVVLGESLSSKGL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCCCCCC
TENMVKEALNPESNIKRRKIPGGPAPEEMKNYLSKRKTELELNAQEIATLKDIIDSAFEN
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLSVVEEYRKI
HHHHHHHHHCC
>Mature Secondary Structure 
SNILRRGRLEAAQDEEILRYTSSMEADRWIFNADIVVDLAHTVMLREQGIIKEEDCSKI
CCHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCHHHHHHH
LSGLLKIREEGMEKLDFSYEDIHISLESRLIDMVGEDVGGRMHSGRSRNDEVATCIRLTL
HHHHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
REELLGLLEEIFALRKTLVSLAEKHSETLMPGFTHLQHAQPTTLAHHLCAHESALGRDFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHH
RVQDAFSRVNLCPLGAAAFASTGFNLNRKRTQELLGFEGLLENSMDAVSSRDFLIECASV
HHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSNLMINLSRIAEELVIWSSSEFNFIELDDMYASTSSIMPQKKNPDTAELMRGKTGVSVG
HHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHH
ALMSLLTICKGLPLSYNRDLQEATPNIWRSVETVRASVRVMEGMVKTMKVHPDVLAAESI
HHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TGFTTATELADTFVRETGIPFRTAHQIVGMLAKEREKPTMEKIDSASEVVLGESLSSKGL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCCCCCC
TENMVKEALNPESNIKRRKIPGGPAPEEMKNYLSKRKTELELNAQEIATLKDIIDSAFEN
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLSVVEEYRKI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA