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The map label for this gene is mtaD [H]

Identifier: 21228381

GI number: 21228381

Start: 2717501

End: 2718874

Strand: Reverse

Name: mtaD [H]

Synonym: MM_2279

Alternate gene names: 21228381

Gene position: 2718874-2717501 (Counterclockwise)

Preceding gene: 21228382

Following gene: 21228380

Centisome position: 66.37

GC content: 48.47

Gene sequence:

>1374_bases
TTGCAATTCAATAAAAGGCAGTTCAATAAAGGCGCAGTCGACAGAGTTGAAATTCAAACCTCAGGATATGATGATATGGC
TGACATAATAATAAAAAATGCTTATGTTTTAACAATGGACCCTGACGCAGGAGATATTAAAAAAGGGACTGTTGTTATTG
AAGATGGAAAAATCACGGAAATAGGAGTGAAAACAAAAGAAAGTGCCGATACCGTGATTGACGCAAAAGGCTCTGTAGTG
ATGCCGGGGCTTGTAAATACGCATACCCATGCAGCAATGACCCTCTTCCGGGGTTATGCCGACGACCTTCAGCTTGCAGA
ATGGCTCGAGAAGCATATCTGGCCTGCCGAAGCCCAGCTTACGGCAGAAGATGTTTACAGAGGAAGCCTGCTCGCGTGCC
TTGAAATGATCAGATCCGGGACGACCTCATTTGCAGATATGTACTTCTTTATGGACGAGACTGCAAAGGCTGTAGAGGCA
TCCGGACTCAGGGCTTCGCTTTCTCACGGTCTAATCGAACTCTGGAACGAAGAAAAAGGGGAAAATGACCTGAAAGAAGG
AAAACGCTTTGTACGCGCCTGGCAGGGAGCAGCGAAAGGCAGGATAAAAACAATGTACGGCCCTCATGCTCCGAATACCT
GTTCTGATGAGTTTCTTGCAAAGGTGAAGGAGGCAGCCAGACAGGACGGAGCGGGGCTTCACATTCATGTCCTGGAAACC
GAAGCCGAACTCCTGGCAATGAAAGAAAGGTACGGGAAATGCTCGGTACATATGCTCGATGATATCGGGTTTTTCGGTCC
AGACGTGCTTGCCGCCCACTGTGTGTGGCTTTCTGACGGGGATATAGAGGTCTTAAGGGAAAAAGGGGTAAATGTGTCCC
ATAATCCCATAAGCAATATGAAACTGGCTTCCGGAACCGCTCCCGTGTATAAGATGCTCGAAAGAGGAGTAAATGTCAGC
CTCGGGACTGACGGCTGTGCCTCAAACAACAACCTTGACCTGTTTGAAGAAATGAAAACTGCTGCCCTTCTCCACAAACT
GAGCACATGCAACCCCACTGCCCTTCCTGCCCGCCAGGTGCTGCAGATGGCAACCGTTAATGGAGCAAAGGCTCTTGGAA
CGGAAACCGGCATGTTGAAGACCGGAATGAAGGCAGACATGATCATAGTTGACATGAAAAAACCGCACCTCACTCCCTGT
TTTGACGTGCCATCCCATCTTGTGTACTCTGCAGGAGGAAGCGATGTCAGGACAACAATCGTGGACGGAAAAATCCTTAT
GCAGGACTACAGAGTTATGGTGCTGGACGAGCAGAAAGTCATCGAAGAAGCCCAAAAAGCCGCAGAAGAGCTGGTAGCAA
GGGTAAATTCCTGA

Upstream 100 bases:

>100_bases
TTTAGTAGATAAAGTTCAATAAAAGGCGGTTCAACAAAAGCGAAGTTAGCAAAATTTCAGTTCAATTAAAGGCTGTCTAA
TAAAAGCGAAGTTAACAAAG

Downstream 100 bases:

>100_bases
AAACAATCCGGCATGAAAATCGTCCGGGGTATAATGCATAATGCATGATACATAATAATACAGGAAAAGTGAATATTGAC
AGAATTACAGAAAAAGTAAG

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MQFNKRQFNKGAVDRVEIQTSGYDDMADIIIKNAYVLTMDPDAGDIKKGTVVIEDGKITEIGVKTKESADTVIDAKGSVV
MPGLVNTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQLTAEDVYRGSLLACLEMIRSGTTSFADMYFFMDETAKAVEA
SGLRASLSHGLIELWNEEKGENDLKEGKRFVRAWQGAAKGRIKTMYGPHAPNTCSDEFLAKVKEAARQDGAGLHIHVLET
EAELLAMKERYGKCSVHMLDDIGFFGPDVLAAHCVWLSDGDIEVLREKGVNVSHNPISNMKLASGTAPVYKMLERGVNVS
LGTDGCASNNNLDLFEEMKTAALLHKLSTCNPTALPARQVLQMATVNGAKALGTETGMLKTGMKADMIIVDMKKPHLTPC
FDVPSHLVYSAGGSDVRTTIVDGKILMQDYRVMVLDEQKVIEEAQKAAEELVARVNS

Sequences:

>Translated_457_residues
MQFNKRQFNKGAVDRVEIQTSGYDDMADIIIKNAYVLTMDPDAGDIKKGTVVIEDGKITEIGVKTKESADTVIDAKGSVV
MPGLVNTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQLTAEDVYRGSLLACLEMIRSGTTSFADMYFFMDETAKAVEA
SGLRASLSHGLIELWNEEKGENDLKEGKRFVRAWQGAAKGRIKTMYGPHAPNTCSDEFLAKVKEAARQDGAGLHIHVLET
EAELLAMKERYGKCSVHMLDDIGFFGPDVLAAHCVWLSDGDIEVLREKGVNVSHNPISNMKLASGTAPVYKMLERGVNVS
LGTDGCASNNNLDLFEEMKTAALLHKLSTCNPTALPARQVLQMATVNGAKALGTETGMLKTGMKADMIIVDMKKPHLTPC
FDVPSHLVYSAGGSDVRTTIVDGKILMQDYRVMVLDEQKVIEEAQKAAEELVARVNS
>Mature_457_residues
MQFNKRQFNKGAVDRVEIQTSGYDDMADIIIKNAYVLTMDPDAGDIKKGTVVIEDGKITEIGVKTKESADTVIDAKGSVV
MPGLVNTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQLTAEDVYRGSLLACLEMIRSGTTSFADMYFFMDETAKAVEA
SGLRASLSHGLIELWNEEKGENDLKEGKRFVRAWQGAAKGRIKTMYGPHAPNTCSDEFLAKVKEAARQDGAGLHIHVLET
EAELLAMKERYGKCSVHMLDDIGFFGPDVLAAHCVWLSDGDIEVLREKGVNVSHNPISNMKLASGTAPVYKMLERGVNVS
LGTDGCASNNNLDLFEEMKTAALLHKLSTCNPTALPARQVLQMATVNGAKALGTETGMLKTGMKADMIIVDMKKPHLTPC
FDVPSHLVYSAGGSDVRTTIVDGKILMQDYRVMVLDEQKVIEEAQKAAEELVARVNS

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=398, Percent_Identity=27.3869346733668, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI87082177, Length=455, Percent_Identity=28.1318681318681, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789249, Length=415, Percent_Identity=25.5421686746988, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17540282, Length=420, Percent_Identity=24.047619047619, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319963, Length=350, Percent_Identity=23.7142857142857, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24643849, Length=386, Percent_Identity=26.6839378238342, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50015; Mature: 50015

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFNKRQFNKGAVDRVEIQTSGYDDMADIIIKNAYVLTMDPDAGDIKKGTVVIEDGKITE
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCEEEEEECCCCCCCCCCEEEEECCEEEE
IGVKTKESADTVIDAKGSVVMPGLVNTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQL
ECCCCCCCCCCEEECCCCEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
TAEDVYRGSLLACLEMIRSGTTSFADMYFFMDETAKAVEASGLRASLSHGLIELWNEEKG
CHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
ENDLKEGKRFVRAWQGAAKGRIKTMYGPHAPNTCSDEFLAKVKEAARQDGAGLHIHVLET
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
EAELLAMKERYGKCSVHMLDDIGFFGPDVLAAHCVWLSDGDIEVLREKGVNVSHNPISNM
HHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHEEEEECCCCHHHHHHCCCCCCCCCCCCC
KLASGTAPVYKMLERGVNVSLGTDGCASNNNLDLFEEMKTAALLHKLSTCNPTALPARQV
EECCCCHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LQMATVNGAKALGTETGMLKTGMKADMIIVDMKKPHLTPCFDVPSHLVYSAGGSDVRTTI
HHHHHCCCCHHCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCHHHEECCCCCCEEEEE
VDGKILMQDYRVMVLDEQKVIEEAQKAAEELVARVNS
ECCEEEEECCEEEEECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFNKRQFNKGAVDRVEIQTSGYDDMADIIIKNAYVLTMDPDAGDIKKGTVVIEDGKITE
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCEEEEEECCCCCCCCCCEEEEECCEEEE
IGVKTKESADTVIDAKGSVVMPGLVNTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQL
ECCCCCCCCCCEEECCCCEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
TAEDVYRGSLLACLEMIRSGTTSFADMYFFMDETAKAVEASGLRASLSHGLIELWNEEKG
CHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
ENDLKEGKRFVRAWQGAAKGRIKTMYGPHAPNTCSDEFLAKVKEAARQDGAGLHIHVLET
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
EAELLAMKERYGKCSVHMLDDIGFFGPDVLAAHCVWLSDGDIEVLREKGVNVSHNPISNM
HHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHEEEEECCCCHHHHHHCCCCCCCCCCCCC
KLASGTAPVYKMLERGVNVSLGTDGCASNNNLDLFEEMKTAALLHKLSTCNPTALPARQV
EECCCCHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LQMATVNGAKALGTETGMLKTGMKADMIIVDMKKPHLTPCFDVPSHLVYSAGGSDVRTTI
HHHHHCCCCHHCCCCCCHHHCCCCCCEEEEECCCCCCCCCCCCCHHHEECCCCCCEEEEE
VDGKILMQDYRVMVLDEQKVIEEAQKAAEELVARVNS
ECCEEEEECCEEEEECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]