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The map label for this gene is ahcY

Identifier: 21228380

GI number: 21228380

Start: 2715977

End: 2717212

Strand: Reverse

Name: ahcY

Synonym: MM_2278

Alternate gene names: 21228380

Gene position: 2717212-2715977 (Counterclockwise)

Preceding gene: 21228381

Following gene: 21228379

Centisome position: 66.33

GC content: 48.79

Gene sequence:

>1236_bases
ATGACAGAAAAAGAACTCATAGAATCCGGAAACATGAAAATGGAATGGGCAAGAAACCACATGCCCGTTCTTGCAATCAT
CAGAGAAAAGTTTGAGAAAGAAAAACCCCTCAAAGGGCTCAAAGTAGGAATGGCACTGCACGTGGAAGCGAAAACCGCAG
TCCTTGTCGAGACTCTCGCTGCTGGAGGTGCACAGGTAGCAATTTCAGGTTGCAACCCCCTGAGCACACAGGATGATGTG
GCAGCTGCTTTAGATACTCGAGAAAACATAAACTGTTTTGCTAAGTACGGGTGCTGCACGGGCGAATATTACGAAGCAAT
TGACAGAGTCCTTGATATTGAGCCTGACATCACAATCGACGATGGTGCAGACCTGATTTTTAAGCTTCACAAAGAAAGGC
AGGAAATGCTTGCGAAAATCCTCGGAGGCTGCGAAGAGACCACCACAGGGGTACACAGGCTTCATGCCATGGAAAAAGAC
GGCGCACTCAAGATGCCGGTAATAGCAGTAAACGATGCCATGACCAAGTACCTTTTTGACAACCGCTACGGGACAGGCCA
GTCAGCATGGGACGGTATAAACCGTACTACAAACCTGCTTGTTGCAGGCAAGAATGTTGTTGTTGCAGGCTACGGCTGGT
GCGGGCGCGGGGTTGCAATGCGGGCTACAGGCCTTGGAGCAAGCGTAATCGTCACTGAAATAGACCCCATAAGAGCCCTT
GAAGCCAGAATGGACGGGCACAGGGTTATGAAAATGTCAGAGGCTGCAAAAATCGGAGACCTCTTTGTCACTGCAACAGG
AAACCGCGATATCCTCACAGCCGACAACTTTAAGGTGATGAAAGACGGGGCAATTTTAGCAAACTCAGGCCACTTCAATG
TAGAAATCGACATGGAAGCCCTTGATTCTCTTGCAAAATCCACAAGGACTGTCAGGCATAATATCAAAGAATACGACATT
GGCAACAGGCGCATTAATGTGATTGCAGAAGGAAGACTCGTAAACCTGGCTGCAGGCGACGGGCACCCTGCCGAGGTTAT
GGATATGAGTTTTGCAAACCAGGCCCTCTGTGTCCGTTATATTGCAGAAAATAAGCTTTCGAGCGGAGTCCACGGGGTCC
CGAGAGAACTTGATACCTATGTTGCAAAACTGAAGCTTGAGTCTATGGGCATAGCCACCGATGAGCTTACTTCCAAGCAG
GAATGCTACATGAGCGGCTGGGAATGTGGAACGTAA

Upstream 100 bases:

>100_bases
TAATTGCAGAGTAACCGATATAAGCCATATTCGGTCATTTCATTCAAAAATTCTATCTACTTCATTCTATCAATCATTTA
TCCAGTATAACGGGATCACC

Downstream 100 bases:

>100_bases
TTTGAAATAAGCTACAGAAGATAATTTCAGTAATTTTAAAATGTTGATTCACAGGTGCAATGAATGCAGGCAGTTCTCCA
TCTTCAGAAATGCAGTACAT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTEKELIESGNMKMEWARNHMPVLAIIREKFEKEKPLKGLKVGMALHVEAKTAVLVETLAAGGAQVAISGCNPLSTQDDV
AAALDTRENINCFAKYGCCTGEYYEAIDRVLDIEPDITIDDGADLIFKLHKERQEMLAKILGGCEETTTGVHRLHAMEKD
GALKMPVIAVNDAMTKYLFDNRYGTGQSAWDGINRTTNLLVAGKNVVVAGYGWCGRGVAMRATGLGASVIVTEIDPIRAL
EARMDGHRVMKMSEAAKIGDLFVTATGNRDILTADNFKVMKDGAILANSGHFNVEIDMEALDSLAKSTRTVRHNIKEYDI
GNRRINVIAEGRLVNLAAGDGHPAEVMDMSFANQALCVRYIAENKLSSGVHGVPRELDTYVAKLKLESMGIATDELTSKQ
ECYMSGWECGT

Sequences:

>Translated_411_residues
MTEKELIESGNMKMEWARNHMPVLAIIREKFEKEKPLKGLKVGMALHVEAKTAVLVETLAAGGAQVAISGCNPLSTQDDV
AAALDTRENINCFAKYGCCTGEYYEAIDRVLDIEPDITIDDGADLIFKLHKERQEMLAKILGGCEETTTGVHRLHAMEKD
GALKMPVIAVNDAMTKYLFDNRYGTGQSAWDGINRTTNLLVAGKNVVVAGYGWCGRGVAMRATGLGASVIVTEIDPIRAL
EARMDGHRVMKMSEAAKIGDLFVTATGNRDILTADNFKVMKDGAILANSGHFNVEIDMEALDSLAKSTRTVRHNIKEYDI
GNRRINVIAEGRLVNLAAGDGHPAEVMDMSFANQALCVRYIAENKLSSGVHGVPRELDTYVAKLKLESMGIATDELTSKQ
ECYMSGWECGT
>Mature_410_residues
TEKELIESGNMKMEWARNHMPVLAIIREKFEKEKPLKGLKVGMALHVEAKTAVLVETLAAGGAQVAISGCNPLSTQDDVA
AALDTRENINCFAKYGCCTGEYYEAIDRVLDIEPDITIDDGADLIFKLHKERQEMLAKILGGCEETTTGVHRLHAMEKDG
ALKMPVIAVNDAMTKYLFDNRYGTGQSAWDGINRTTNLLVAGKNVVVAGYGWCGRGVAMRATGLGASVIVTEIDPIRALE
ARMDGHRVMKMSEAAKIGDLFVTATGNRDILTADNFKVMKDGAILANSGHFNVEIDMEALDSLAKSTRTVRHNIKEYDIG
NRRINVIAEGRLVNLAAGDGHPAEVMDMSFANQALCVRYIAENKLSSGVHGVPRELDTYVAKLKLESMGIATDELTSKQE
CYMSGWECGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=406, Percent_Identity=43.8423645320197, Blast_Score=301, Evalue=6e-82,
Organism=Homo sapiens, GI239937451, Length=395, Percent_Identity=44.3037974683544, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI298286489, Length=404, Percent_Identity=38.6138613861386, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI195539349, Length=404, Percent_Identity=38.6138613861386, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI195539337, Length=404, Percent_Identity=38.6138613861386, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI24308043, Length=404, Percent_Identity=38.6138613861386, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI21361647, Length=404, Percent_Identity=38.6138613861386, Blast_Score=255, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17506425, Length=410, Percent_Identity=40.9756097560976, Blast_Score=295, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6320882, Length=417, Percent_Identity=41.2470023980815, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24642172, Length=406, Percent_Identity=44.0886699507389, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24656245, Length=403, Percent_Identity=37.9652605459057, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI45553385, Length=400, Percent_Identity=38.75, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI45553387, Length=400, Percent_Identity=38.75, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_METMA (Q8PUQ4)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634302.1
- ProteinModelPortal:   Q8PUQ4
- SMR:   Q8PUQ4
- GeneID:   1480620
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2278
- NMPDR:   fig|192952.1.peg.2278
- HOGENOM:   HBG352029
- OMA:   KMEWARN
- ProtClustDB:   PRK05476
- BioCyc:   MMAZ192952:MM2278-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 44836; Mature: 44705

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 121-121 BINDING 146-146 BINDING 176-176 BINDING 180-180 BINDING 181-181 BINDING 233-233 BINDING 268-268 BINDING 335-335

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKELIESGNMKMEWARNHMPVLAIIREKFEKEKPLKGLKVGMALHVEAKTAVLVETLA
CCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEECHHHHHHHHHH
AGGAQVAISGCNPLSTQDDVAAALDTRENINCFAKYGCCTGEYYEAIDRVLDIEPDITID
CCCCEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEC
DGADLIFKLHKERQEMLAKILGGCEETTTGVHRLHAMEKDGALKMPVIAVNDAMTKYLFD
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEECCEEEECHHHHHHHHC
NRYGTGQSAWDGINRTTNLLVAGKNVVVAGYGWCGRGVAMRATGLGASVIVTEIDPIRAL
CCCCCCCHHHCCCCCCEEEEEECCEEEEEECCCCCCCCEEEECCCCCEEEEECCCHHHHH
EARMDGHRVMKMSEAAKIGDLFVTATGNRDILTADNFKVMKDGAILANSGHFNVEIDMEA
HHHCCCHHHHHHHHHHCCCEEEEEECCCCCEEECCCEEEEECCEEEECCCEEEEEEEHHH
LDSLAKSTRTVRHNIKEYDIGNRRINVIAEGRLVNLAAGDGHPAEVMDMSFANQALCVRY
HHHHHHHHHHHHHCHHHCCCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHCCHHHHHHH
IAENKLSSGVHGVPRELDTYVAKLKLESMGIATDELTSKQECYMSGWECGT
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TEKELIESGNMKMEWARNHMPVLAIIREKFEKEKPLKGLKVGMALHVEAKTAVLVETLA
CHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEECHHHHHHHHHH
AGGAQVAISGCNPLSTQDDVAAALDTRENINCFAKYGCCTGEYYEAIDRVLDIEPDITID
CCCCEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEC
DGADLIFKLHKERQEMLAKILGGCEETTTGVHRLHAMEKDGALKMPVIAVNDAMTKYLFD
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEECCEEEECHHHHHHHHC
NRYGTGQSAWDGINRTTNLLVAGKNVVVAGYGWCGRGVAMRATGLGASVIVTEIDPIRAL
CCCCCCCHHHCCCCCCEEEEEECCEEEEEECCCCCCCCEEEECCCCCEEEEECCCHHHHH
EARMDGHRVMKMSEAAKIGDLFVTATGNRDILTADNFKVMKDGAILANSGHFNVEIDMEA
HHHCCCHHHHHHHHHHCCCEEEEEECCCCCEEECCCEEEEECCEEEECCCEEEEEEEHHH
LDSLAKSTRTVRHNIKEYDIGNRRINVIAEGRLVNLAAGDGHPAEVMDMSFANQALCVRY
HHHHHHHHHHHHHCHHHCCCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHCCHHHHHHH
IAENKLSSGVHGVPRELDTYVAKLKLESMGIATDELTSKQECYMSGWECGT
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824