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The map label for this gene is arsM [C]

Identifier: 21228345

GI number: 21228345

Start: 2671417

End: 2672163

Strand: Direct

Name: arsM [C]

Synonym: MM_2243

Alternate gene names: 21228345

Gene position: 2671417-2672163 (Clockwise)

Preceding gene: 21228344

Following gene: 21228346

Centisome position: 65.21

GC content: 43.91

Gene sequence:

>747_bases
ATGGATGCGAATGAAAAAAAGGAAGTTATCAAAAAGAAGTATCAGGAAATTGCAATTTTAGGGGGCTCCTGCTGTTCTGG
CGGATGCTGCGGTGATTCTAACTCAACAGACCTTTCCAGGTCACTTGGTTATTCCGAATCTGACGTTCAGGCTGTTCCGG
ATGCGAATATGGGTCTTGGCTGCGGCAATCCTACCGCTTTTGCAGAACTGAAACCCGGAGATGTCGTTCTGGATCTGGGT
TCTGGCGGGGGTTTTGATTGTTTTCTTGCTGCACAGAAAATAGGAAGCTCAGGAAAAGTTATCGGGGTCGATATGACTCT
TGAAATGGTTGAAAAAGCGCAGGCTAATGCCCGAAAATATGGCTACTCAAATGTAGAATTCCGCCATGGGGATATTGAGT
CTCTTCCGGTTAAAGATAGTTCTGTGGATGTTATTATCAGTAACTGTGTTATTAACCTGGCTCCTGATAAGGAAAAAGTT
TTCAGAGAGGCGTTCCGTGTTCTGAAACCGGAAGGCAGAATGTATATTTCGGACATGGTTCTCCTTGATGAGCTGCCTGA
AGAACTTAAAAATGACAGTGAGCTGCTTGCGGGTTGTATTGCTGGTGCCGTTTTAAAAGAGGAATATTTGGGGCTTCTGA
AAAAGGCAGGGTTTTCGGTTGAAATCCTGAATGAAGATTTAGATATCAGTAAAAGGCAATACAGAGATTTGCCAGTCGAA
AGCCTGAAATTAAAAGCCCGGGTGTAA

Upstream 100 bases:

>100_bases
TGAGAGTACTGAAAACCGGGTTGAAAACAAAGCTAAAGATAACTGAAAGTAAGCTCAAAACAAATAGAAAAATATCAACG
ATAAGGAATGGGATATAAAA

Downstream 100 bases:

>100_bases
TAGAAGACAGGACAAATATGGAATAAAGTATGGGTGGATATCAGCAGTTCCTGATGGTTACTCTTACCGATTTTCAATTT
TTCTCTTAATACTTAAAGAA

Product: arsenite S-adenosylmethyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MDANEKKEVIKKKYQEIAILGGSCCSGGCCGDSNSTDLSRSLGYSESDVQAVPDANMGLGCGNPTAFAELKPGDVVLDLG
SGGGFDCFLAAQKIGSSGKVIGVDMTLEMVEKAQANARKYGYSNVEFRHGDIESLPVKDSSVDVIISNCVINLAPDKEKV
FREAFRVLKPEGRMYISDMVLLDELPEELKNDSELLAGCIAGAVLKEEYLGLLKKAGFSVEILNEDLDISKRQYRDLPVE
SLKLKARV

Sequences:

>Translated_248_residues
MDANEKKEVIKKKYQEIAILGGSCCSGGCCGDSNSTDLSRSLGYSESDVQAVPDANMGLGCGNPTAFAELKPGDVVLDLG
SGGGFDCFLAAQKIGSSGKVIGVDMTLEMVEKAQANARKYGYSNVEFRHGDIESLPVKDSSVDVIISNCVINLAPDKEKV
FREAFRVLKPEGRMYISDMVLLDELPEELKNDSELLAGCIAGAVLKEEYLGLLKKAGFSVEILNEDLDISKRQYRDLPVE
SLKLKARV
>Mature_248_residues
MDANEKKEVIKKKYQEIAILGGSCCSGGCCGDSNSTDLSRSLGYSESDVQAVPDANMGLGCGNPTAFAELKPGDVVLDLG
SGGGFDCFLAAQKIGSSGKVIGVDMTLEMVEKAQANARKYGYSNVEFRHGDIESLPVKDSSVDVIISNCVINLAPDKEKV
FREAFRVLKPEGRMYISDMVLLDELPEELKNDSELLAGCIAGAVLKEEYLGLLKKAGFSVEILNEDLDISKRQYRDLPVE
SLKLKARV

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI109389364, Length=152, Percent_Identity=46.0526315789474, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI48994983, Length=108, Percent_Identity=32.4074074074074, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR005149
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08241 Methyltransf_11; PF03551 PadR [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 26784; Mature: 26784

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDANEKKEVIKKKYQEIAILGGSCCSGGCCGDSNSTDLSRSLGYSESDVQAVPDANMGLG
CCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
CGNPTAFAELKPGDVVLDLGSGGGFDCFLAAQKIGSSGKVIGVDMTLEMVEKAQANARKY
CCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHC
GYSNVEFRHGDIESLPVKDSSVDVIISNCVINLAPDKEKVFREAFRVLKPEGRMYISDMV
CCCCCEEECCCCCCCCCCCCCHHEEEECEEEEECCCHHHHHHHHHHHHCCCCCEEHHHHH
LLDELPEELKNDSELLAGCIAGAVLKEEYLGLLKKAGFSVEILNEDLDISKRQYRDLPVE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCCHH
SLKLKARV
HHEEEECC
>Mature Secondary Structure
MDANEKKEVIKKKYQEIAILGGSCCSGGCCGDSNSTDLSRSLGYSESDVQAVPDANMGLG
CCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
CGNPTAFAELKPGDVVLDLGSGGGFDCFLAAQKIGSSGKVIGVDMTLEMVEKAQANARKY
CCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHC
GYSNVEFRHGDIESLPVKDSSVDVIISNCVINLAPDKEKVFREAFRVLKPEGRMYISDMV
CCCCCEEECCCCCCCCCCCCCHHEEEECEEEEECCCHHHHHHHHHHHHCCCCCEEHHHHH
LLDELPEELKNDSELLAGCIAGAVLKEEYLGLLKKAGFSVEILNEDLDISKRQYRDLPVE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHCCCHH
SLKLKARV
HHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2155856 [H]