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The map label for this gene is fgd1 [H]

Identifier: 21228297

GI number: 21228297

Start: 2607117

End: 2608115

Strand: Reverse

Name: fgd1 [H]

Synonym: MM_2195

Alternate gene names: 21228297

Gene position: 2608115-2607117 (Counterclockwise)

Preceding gene: 21228298

Following gene: 21228292

Centisome position: 63.67

GC content: 46.95

Gene sequence:

>999_bases
ATGTTAAAAATAGGATACAAAATTGGAGCTGAGCAGTTTTTACCGTCAGAGATGCTTGAGCAGGCGATTGTAGCCGAGAA
AAACGGGTTTGAAAGCATAGATGTGAGTGACCATTTCCATCCCTGGAGCGAAGAAGGACAGGCATGTTTTTCCTGGAGCT
GGCTTGGAGCCGCAGCTGCAAGGACAGAGACCATTGAACTGGGACCCGGAGTTACATGCCCTATTCTGCGCTATAACCCG
GCAATTATTGCCCAGGCAGCAGCAACTGTCTCTTCTCTGGCTGGAGGCAGGACCTACCTTGGAGTCGGGACCGGGGAAGC
GCTCAATGAATATCCGGTAACCTTCGAATGGCCGGCTTTTAGAGAGCGCCAGGCAATGATGATAGAAGCCGTACAGCTTA
TCCGCAGCCTGTGGACAGGAGAAAAAGTAGATTTTCAAGGGTGCTATTATCGGACAAAGCAGGCTAAACTTTATACCCTG
CCCAAAAATGAGATTCCTATTTACATTTCTTCCCTTGTTCCGGAAAGCGCCTATCTTGCCGGGTATTATGGAGACGGCCT
CATTACCGTAGGAGGGTCTCTTGAGATACCGGAATATGAAAGGATGCTCTCTGAGGTCAGAAGAGGGGCTACTGATGCAG
GCAGAGATTTTGAGAAGATGCCAAAAGCCGTGGAGCTTTTTGTGGAGTATACAGATGATACCGAAAAAGTGGTTGAAAGC
TTTAAAAAATACTGGGCAGGGGCTATGATCCCGGCCCTTTTCCTGAATAAAATCTATACTCCTGCGATGTCTGCCCAAAA
CGGCAAGGTAGTTGGCAGGGATACTATTCAAAAATCAGTCTGTATTTCGGGAGACCCTGAAAAGCACATAGAATATGTAA
AGCAGTACATCGATGCAGGTTTCACACATTTTTATTTCCATTCTGCAGCCGGGGACCAGATAGACTTTCTTGAAAGGTAC
GGAAAAGACGTTTTACCTGCTTTAAAGAAGATGGGATGA

Upstream 100 bases:

>100_bases
CTATTTTTATCGCCACATTATCAGAGGCGTCAGGACCTTATTATATTAACGCAAAAAATATAATTATCCGAGATATAACT
GGAGATACCGGGGGTCAAAT

Downstream 100 bases:

>100_bases
ATTTCCCATCAGGTTTTATTTTTTTACATATTACAAAGTTTTTTGTAATTTCCGGCTTTTACCTGTCTTTTTTACCTGTC
TCTTTTGCCTGTCTTTTTGC

Product: F420-dependent glucose-6-phosphate dehydrogenase

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MLKIGYKIGAEQFLPSEMLEQAIVAEKNGFESIDVSDHFHPWSEEGQACFSWSWLGAAAARTETIELGPGVTCPILRYNP
AIIAQAAATVSSLAGGRTYLGVGTGEALNEYPVTFEWPAFRERQAMMIEAVQLIRSLWTGEKVDFQGCYYRTKQAKLYTL
PKNEIPIYISSLVPESAYLAGYYGDGLITVGGSLEIPEYERMLSEVRRGATDAGRDFEKMPKAVELFVEYTDDTEKVVES
FKKYWAGAMIPALFLNKIYTPAMSAQNGKVVGRDTIQKSVCISGDPEKHIEYVKQYIDAGFTHFYFHSAAGDQIDFLERY
GKDVLPALKKMG

Sequences:

>Translated_332_residues
MLKIGYKIGAEQFLPSEMLEQAIVAEKNGFESIDVSDHFHPWSEEGQACFSWSWLGAAAARTETIELGPGVTCPILRYNP
AIIAQAAATVSSLAGGRTYLGVGTGEALNEYPVTFEWPAFRERQAMMIEAVQLIRSLWTGEKVDFQGCYYRTKQAKLYTL
PKNEIPIYISSLVPESAYLAGYYGDGLITVGGSLEIPEYERMLSEVRRGATDAGRDFEKMPKAVELFVEYTDDTEKVVES
FKKYWAGAMIPALFLNKIYTPAMSAQNGKVVGRDTIQKSVCISGDPEKHIEYVKQYIDAGFTHFYFHSAAGDQIDFLERY
GKDVLPALKKMG
>Mature_332_residues
MLKIGYKIGAEQFLPSEMLEQAIVAEKNGFESIDVSDHFHPWSEEGQACFSWSWLGAAAARTETIELGPGVTCPILRYNP
AIIAQAAATVSSLAGGRTYLGVGTGEALNEYPVTFEWPAFRERQAMMIEAVQLIRSLWTGEKVDFQGCYYRTKQAKLYTL
PKNEIPIYISSLVPESAYLAGYYGDGLITVGGSLEIPEYERMLSEVRRGATDAGRDFEKMPKAVELFVEYTDDTEKVVES
FKKYWAGAMIPALFLNKIYTPAMSAQNGKVVGRDTIQKSVCISGDPEKHIEYVKQYIDAGFTHFYFHSAAGDQIDFLERY
GKDVLPALKKMG

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787247, Length=208, Percent_Identity=26.4423076923077, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 37010; Mature: 37010

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIGYKIGAEQFLPSEMLEQAIVAEKNGFESIDVSDHFHPWSEEGQACFSWSWLGAAAA
CEEECCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHH
RTETIELGPGVTCPILRYNPAIIAQAAATVSSLAGGRTYLGVGTGEALNEYPVTFEWPAF
CCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCEEECCCH
RERQAMMIEAVQLIRSLWTGEKVDFQGCYYRTKQAKLYTLPKNEIPIYISSLVPESAYLA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEECCCCCCCEEEHHHCCCCCEEE
GYYGDGLITVGGSLEIPEYERMLSEVRRGATDAGRDFEKMPKAVELFVEYTDDTEKVVES
EEECCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
FKKYWAGAMIPALFLNKIYTPAMSAQNGKVVGRDTIQKSVCISGDPEKHIEYVKQYIDAG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCEECCCCHHHHHHHHHHHHHCC
FTHFYFHSAAGDQIDFLERYGKDVLPALKKMG
CCEEEEECCCCCHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MLKIGYKIGAEQFLPSEMLEQAIVAEKNGFESIDVSDHFHPWSEEGQACFSWSWLGAAAA
CEEECCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHH
RTETIELGPGVTCPILRYNPAIIAQAAATVSSLAGGRTYLGVGTGEALNEYPVTFEWPAF
CCEEEECCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCEEECCCH
RERQAMMIEAVQLIRSLWTGEKVDFQGCYYRTKQAKLYTLPKNEIPIYISSLVPESAYLA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEECCCCCCCEEEHHHCCCCCEEE
GYYGDGLITVGGSLEIPEYERMLSEVRRGATDAGRDFEKMPKAVELFVEYTDDTEKVVES
EEECCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
FKKYWAGAMIPALFLNKIYTPAMSAQNGKVVGRDTIQKSVCISGDPEKHIEYVKQYIDAG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCEECCCCHHHHHHHHHHHHHCC
FTHFYFHSAAGDQIDFLERYGKDVLPALKKMG
CCEEEEECCCCCHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]