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The map label for this gene is secY [H]

Identifier: 21228249

GI number: 21228249

Start: 2550126

End: 2551601

Strand: Direct

Name: secY [H]

Synonym: MM_2147

Alternate gene names: 21228249

Gene position: 2550126-2551601 (Clockwise)

Preceding gene: 21228248

Following gene: 21228250

Centisome position: 62.25

GC content: 47.56

Gene sequence:

>1476_bases
ATGACTCTCAGGGATACCTTAGAACCGTTTTTTAATAAGTTACCTGCAGTAGCAAGTCCGGAAAAACATGTCCACTTTAA
AGATAAACTCTGGTGGACTCTGGGAATTCTGGTGCTGTATTTTGCTCTTGCAAATGTGCCGCTCTTCGGAATGTCTCAGG
ATTCTATTGACCTTTTTGAATCTTATCGTGCCTTCTTTGCCGGGGCTTCGGGAACTTTAGTTCTCCTTGGTATAGGTCCA
ATTGTTACGGCTTCCATTGTCCTGCAGCTTCTTGTCGGGGCAGACATTATCAAACTGGACCTTTCGGACCCCAGAGATCA
GTCATTCTTCCAGGGATCTCAGAAGTTCCTTGTCTTTGTTATGATTATTCTGGAAGCTCTTCCACAGCTTCTTGGTGGAT
ACATCCAGCCGGATCCGGGGCTTGCTTCTACTCTTGGTGTAGGCCTGGGAGTGATCACTTTACTGCTCCTTGTCCAGATC
TTTATTGGAGGCGTGCTGGTTCTTTTCATGGACGAAGTGGTCTCCAAATGGGGTATCGGTTCAGGAGTCGGGCTTTTCAT
AGTTGCGGGAATCTCTCAGCAGATCGTTACAGGGATATTTAACTGGGAAATGGAAAACGGGCTCCCTGTAGGTCTTATTC
CCAAATGGATTTACATAGCCCAGAATACCGATGCAGGCTACCTCTTATCCGGTGAAGGCCTTTTATTCATGCTGGTCAGT
GGAGGCATTCTTGCTCTCCTGAGTACGATTGCTATCTTCCTGCTCGTGGTGTATGTGGAGAGTACAAGAATAGAAATCCC
TCTCGCTCACAGTGCAGTTAGAGGAGCAAGGGGCCGCTTCCCGGTCAAACTTATTTACGCATCAGTCCTGCCAATGATCC
TTGTCAGGGCTCTTCAGGCTAACATCCAGATGGTAGGGATTATTCTTTCCGGCAGAGGGATTACTTTCCTCGGAGAATTC
AGCGGCTCAACCCCATTGAACGGGATCATGTATTATCTGTCTCCTATAAACAGCCCATATGACTGGATCCCGTCCCTGGT
ACAGCAATCATTTGCAAGCTATGGGGCAACCGCTCCGGCTATGTGGCAGATCGCACTGCATGTCTTTATAGATGCCACGT
TTCTGATTGCAGGAGGTATTATCTTTGCCCTCTTCTGGATAGAGACTACAGGCATGGGTGCTAAACAGACAGCTCAGAAG
ATCTTCAACTCAGGTATGCAGATTCCTGGTTTCAGGCGGAACATCAGCAGTATTGAAAAAGTCATGCAGCGTTATATCCC
AAAGGTTACCGTTATAGGCGGGGCTTTTATAGGATTACTGACCCTGATTGCGAGCCTGCTCGGTACTCTTGGAAGTGCTG
GAGGTACGGGGCTTTTGCTGACTGTAAGTATTGTGTACCGTCTGTATGAGGATATAGCTTCCGAGCAGATGATGGAGATG
CACCCGATGATTCGTTCTTTCTTTGGGGAGCAATGA

Upstream 100 bases:

>100_bases
ACTTTTTATATTAGGTGTGCTATATACCATTATTTTACGGTAAAAGCATAATCTAATATTTAAAATAGTAAAAAAATTTA
TGTTTTGAATGGTGTAATCG

Downstream 100 bases:

>100_bases
AACTTTATAACTTTTTATTGCAGGGCTAACTGAAAAAGATAGATGATTAAGGGAAAACAATCAAATAAAAGGATGCAAAA
AGGGGATCTTCGATGAATAT

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTLRDTLEPFFNKLPAVASPEKHVHFKDKLWWTLGILVLYFALANVPLFGMSQDSIDLFESYRAFFAGASGTLVLLGIGP
IVTASIVLQLLVGADIIKLDLSDPRDQSFFQGSQKFLVFVMIILEALPQLLGGYIQPDPGLASTLGVGLGVITLLLLVQI
FIGGVLVLFMDEVVSKWGIGSGVGLFIVAGISQQIVTGIFNWEMENGLPVGLIPKWIYIAQNTDAGYLLSGEGLLFMLVS
GGILALLSTIAIFLLVVYVESTRIEIPLAHSAVRGARGRFPVKLIYASVLPMILVRALQANIQMVGIILSGRGITFLGEF
SGSTPLNGIMYYLSPINSPYDWIPSLVQQSFASYGATAPAMWQIALHVFIDATFLIAGGIIFALFWIETTGMGAKQTAQK
IFNSGMQIPGFRRNISSIEKVMQRYIPKVTVIGGAFIGLLTLIASLLGTLGSAGGTGLLLTVSIVYRLYEDIASEQMMEM
HPMIRSFFGEQ

Sequences:

>Translated_491_residues
MTLRDTLEPFFNKLPAVASPEKHVHFKDKLWWTLGILVLYFALANVPLFGMSQDSIDLFESYRAFFAGASGTLVLLGIGP
IVTASIVLQLLVGADIIKLDLSDPRDQSFFQGSQKFLVFVMIILEALPQLLGGYIQPDPGLASTLGVGLGVITLLLLVQI
FIGGVLVLFMDEVVSKWGIGSGVGLFIVAGISQQIVTGIFNWEMENGLPVGLIPKWIYIAQNTDAGYLLSGEGLLFMLVS
GGILALLSTIAIFLLVVYVESTRIEIPLAHSAVRGARGRFPVKLIYASVLPMILVRALQANIQMVGIILSGRGITFLGEF
SGSTPLNGIMYYLSPINSPYDWIPSLVQQSFASYGATAPAMWQIALHVFIDATFLIAGGIIFALFWIETTGMGAKQTAQK
IFNSGMQIPGFRRNISSIEKVMQRYIPKVTVIGGAFIGLLTLIASLLGTLGSAGGTGLLLTVSIVYRLYEDIASEQMMEM
HPMIRSFFGEQ
>Mature_490_residues
TLRDTLEPFFNKLPAVASPEKHVHFKDKLWWTLGILVLYFALANVPLFGMSQDSIDLFESYRAFFAGASGTLVLLGIGPI
VTASIVLQLLVGADIIKLDLSDPRDQSFFQGSQKFLVFVMIILEALPQLLGGYIQPDPGLASTLGVGLGVITLLLLVQIF
IGGVLVLFMDEVVSKWGIGSGVGLFIVAGISQQIVTGIFNWEMENGLPVGLIPKWIYIAQNTDAGYLLSGEGLLFMLVSG
GILALLSTIAIFLLVVYVESTRIEIPLAHSAVRGARGRFPVKLIYASVLPMILVRALQANIQMVGIILSGRGITFLGEFS
GSTPLNGIMYYLSPINSPYDWIPSLVQQSFASYGATAPAMWQIALHVFIDATFLIAGGIIFALFWIETTGMGAKQTAQKI
FNSGMQIPGFRRNISSIEKVMQRYIPKVTVIGGAFIGLLTLIASLLGTLGSAGGTGLLLTVSIVYRLYEDIASEQMMEMH
PMIRSFFGEQ

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI7019415, Length=492, Percent_Identity=32.3170731707317, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI14589847, Length=492, Percent_Identity=31.9105691056911, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI217330618, Length=492, Percent_Identity=30.8943089430894, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI217330616, Length=447, Percent_Identity=30.2013422818792, Blast_Score=180, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17543770, Length=490, Percent_Identity=31.6326530612245, Blast_Score=215, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323411, Length=491, Percent_Identity=30.7535641547862, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6319760, Length=500, Percent_Identity=23, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920826, Length=499, Percent_Identity=31.6633266533066, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 53230; Mature: 53099

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRDTLEPFFNKLPAVASPEKHVHFKDKLWWTLGILVLYFALANVPLFGMSQDSIDLFE
CCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHH
SYRAFFAGASGTLVLLGIGPIVTASIVLQLLVGADIIKLDLSDPRDQSFFQGSQKFLVFV
HHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHHH
MIILEALPQLLGGYIQPDPGLASTLGVGLGVITLLLLVQIFIGGVLVLFMDEVVSKWGIG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SGVGLFIVAGISQQIVTGIFNWEMENGLPVGLIPKWIYIAQNTDAGYLLSGEGLLFMLVS
CCCHHHHHHCCHHHHHHHHHCEECCCCCCEEECCCEEEEEECCCCCEEECCCCEEEHHHH
GGILALLSTIAIFLLVVYVESTRIEIPLAHSAVRGARGRFPVKLIYASVLPMILVRALQA
CCHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
NIQMVGIILSGRGITFLGEFSGSTPLNGIMYYLSPINSPYDWIPSLVQQSFASYGATAPA
CCEEEEEEEECCCEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHH
MWQIALHVFIDATFLIAGGIIFALFWIETTGMGAKQTAQKIFNSGMQIPGFRRNISSIEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
VMQRYIPKVTVIGGAFIGLLTLIASLLGTLGSAGGTGLLLTVSIVYRLYEDIASEQMMEM
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HPMIRSFFGEQ
HHHHHHHCCCC
>Mature Secondary Structure 
TLRDTLEPFFNKLPAVASPEKHVHFKDKLWWTLGILVLYFALANVPLFGMSQDSIDLFE
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHH
SYRAFFAGASGTLVLLGIGPIVTASIVLQLLVGADIIKLDLSDPRDQSFFQGSQKFLVFV
HHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHHH
MIILEALPQLLGGYIQPDPGLASTLGVGLGVITLLLLVQIFIGGVLVLFMDEVVSKWGIG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SGVGLFIVAGISQQIVTGIFNWEMENGLPVGLIPKWIYIAQNTDAGYLLSGEGLLFMLVS
CCCHHHHHHCCHHHHHHHHHCEECCCCCCEEECCCEEEEEECCCCCEEECCCCEEEHHHH
GGILALLSTIAIFLLVVYVESTRIEIPLAHSAVRGARGRFPVKLIYASVLPMILVRALQA
CCHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
NIQMVGIILSGRGITFLGEFSGSTPLNGIMYYLSPINSPYDWIPSLVQQSFASYGATAPA
CCEEEEEEEECCCEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHH
MWQIALHVFIDATFLIAGGIIFALFWIETTGMGAKQTAQKIFNSGMQIPGFRRNISSIEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
VMQRYIPKVTVIGGAFIGLLTLIASLLGTLGSAGGTGLLLTVSIVYRLYEDIASEQMMEM
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HPMIRSFFGEQ
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]