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The map label for this gene is adk [H]

Identifier: 21228250

GI number: 21228250

Start: 2551694

End: 2552341

Strand: Direct

Name: adk [H]

Synonym: MM_2148

Alternate gene names: 21228250

Gene position: 2551694-2552341 (Clockwise)

Preceding gene: 21228249

Following gene: 21228251

Centisome position: 62.29

GC content: 47.84

Gene sequence:

>648_bases
ATGAATATAATACTCTTCGGGCCCCCGGGTGCCGGCAAAGGTACCCAGGCCAAAAAACTGGTTGACTTCTACGGAATTCC
GCAGATTTCCACAGGAGATATCCTGCGGGCAAATGTTAGAGAAGGAACGGAACTGGGACTTGCAGCCAAGGCATACATGG
ACAAAGGAGAACTTGTCCCTGATAACGTACTTATAGGCATTATCAAAAACCGCCTTAATGAGGAAGACTGCAAAAAAGGC
TTCATTCTTGACGGATACCCGAGAACTGTCCCTCAGGCTGATGCCCTGGAAACAATCCTCGATGAAATTGACAAGCCCAT
CGACGTCGTCCTCAACCTTGAGGTTCCTGATGAAGTGCTTGTGGAAAGGATAAGCGGGCGCCTTATGTGCAAATGTGGGG
CAAGCTATCACACAATTGCCAACCCACCAAAGAAGGACAATATCTGCGATATCTGCGGCGGCGAAGTCTACCAGAGGGAC
GACGACAAAGCAGAGGCTGTCCAGAACCGTCTGGACGTTTACAAGAAGCAGACCCAGCCTCTTATCAATTATTATGAAGA
AAAGGGCATTCTTGTCACACTTGACGGCACAAAGGACATAAATGTGGTCTTTGAGGATATAAAAGCAGTTCTGGCAAAAT
TTGCCTGA

Upstream 100 bases:

>100_bases
AGCAATGAAACTTTATAACTTTTTATTGCAGGGCTAACTGAAAAAGATAGATGATTAAGGGAAAACAATCAAATAAAAGG
ATGCAAAAAGGGGATCTTCG

Downstream 100 bases:

>100_bases
ATTTCTTTTCCTCTTATTTTTGTTTTTGTTTTTCTGTTTGTTTATTCTTGCTTTCCTTTTTGTTTTTGTTTTTGTTTTTG
TTTTTGTTTTTGTTTTTGGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNIILFGPPGAGKGTQAKKLVDFYGIPQISTGDILRANVREGTELGLAAKAYMDKGELVPDNVLIGIIKNRLNEEDCKKG
FILDGYPRTVPQADALETILDEIDKPIDVVLNLEVPDEVLVERISGRLMCKCGASYHTIANPPKKDNICDICGGEVYQRD
DDKAEAVQNRLDVYKKQTQPLINYYEEKGILVTLDGTKDINVVFEDIKAVLAKFA

Sequences:

>Translated_215_residues
MNIILFGPPGAGKGTQAKKLVDFYGIPQISTGDILRANVREGTELGLAAKAYMDKGELVPDNVLIGIIKNRLNEEDCKKG
FILDGYPRTVPQADALETILDEIDKPIDVVLNLEVPDEVLVERISGRLMCKCGASYHTIANPPKKDNICDICGGEVYQRD
DDKAEAVQNRLDVYKKQTQPLINYYEEKGILVTLDGTKDINVVFEDIKAVLAKFA
>Mature_215_residues
MNIILFGPPGAGKGTQAKKLVDFYGIPQISTGDILRANVREGTELGLAAKAYMDKGELVPDNVLIGIIKNRLNEEDCKKG
FILDGYPRTVPQADALETILDEIDKPIDVVLNLEVPDEVLVERISGRLMCKCGASYHTIANPPKKDNICDICGGEVYQRD
DDKAEAVQNRLDVYKKQTQPLINYYEEKGILVTLDGTKDINVVFEDIKAVLAKFA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=43.4579439252336, Blast_Score=187, Evalue=4e-48,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=44.0758293838863, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=38.6792452830189, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=37.1859296482412, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=37.1859296482412, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=37.1859296482412, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=37.1859296482412, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4502011, Length=206, Percent_Identity=31.0679611650485, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=32.5471698113208, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=32.5471698113208, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=29.6650717703349, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=27.0642201834862, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI237858799, Length=129, Percent_Identity=35.6589147286822, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=47.2477064220183, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=42.3255813953488, Blast_Score=174, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=33.6405529953917, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=31.924882629108, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=212, Percent_Identity=26.8867924528302, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=24.8826291079812, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=215, Percent_Identity=23.7209302325581, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=45.1162790697674, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=40.0990099009901, Blast_Score=141, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=28.2296650717703, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=42.9906542056075, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17737899, Length=205, Percent_Identity=37.5609756097561, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645822, Length=205, Percent_Identity=37.5609756097561, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24663208, Length=206, Percent_Identity=29.126213592233, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17647141, Length=206, Percent_Identity=29.126213592233, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=27.0142180094787, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=27.0142180094787, Blast_Score=90, Evalue=9e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR008144 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23726; Mature: 23726

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILFGPPGAGKGTQAKKLVDFYGIPQISTGDILRANVREGTELGLAAKAYMDKGELVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCC
DNVLIGIIKNRLNEEDCKKGFILDGYPRTVPQADALETILDEIDKPIDVVLNLEVPDEVL
CHHHHHHHHHHCCHHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHH
VERISGRLMCKCGASYHTIANPPKKDNICDICGGEVYQRDDDKAEAVQNRLDVYKKQTQP
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LINYYEEKGILVTLDGTKDINVVFEDIKAVLAKFA
HHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIILFGPPGAGKGTQAKKLVDFYGIPQISTGDILRANVREGTELGLAAKAYMDKGELVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCC
DNVLIGIIKNRLNEEDCKKGFILDGYPRTVPQADALETILDEIDKPIDVVLNLEVPDEVL
CHHHHHHHHHHCCHHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHH
VERISGRLMCKCGASYHTIANPPKKDNICDICGGEVYQRDDDKAEAVQNRLDVYKKQTQP
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LINYYEEKGILVTLDGTKDINVVFEDIKAVLAKFA
HHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]