Click here to switch to the map view.

The map label for this gene is syrB [H]

Identifier: 21227995

GI number: 21227995

Start: 2249070

End: 2250389

Strand: Reverse

Name: syrB [H]

Synonym: MM_1893

Alternate gene names: 21227995

Gene position: 2250389-2249070 (Counterclockwise)

Preceding gene: 21227996

Following gene: 21227994

Centisome position: 54.94

GC content: 51.06

Gene sequence:

>1320_bases
ATGACAATACAAAACCGCCTTCCTCATCGCATTCATGTTCTAGCAAAGCCAGCAGGGGCTATCTGCAACCTGGCCTGCAA
ATACTGTTTTTTTCTTGACAAGGAACTGCTCTATCCTGGCAGCAGGTTCCGCATGTCAGATGAAATACTGGAGAACTATA
TCCGGCAGCTCATCGCAGCCCACAGCAGTCCGCAGGTGACCGTTGCCTGGCAGGGAGGTGAACCCACGCTTATGGGCGTC
GACTTTTACCGGCGTGCAATTGAGCTGCAAGAAAAACACAGAAAACCAGGCATGAAGTTCGAAAACACAATGCAGACAAA
TGGCACGCTGCTGGACGACGAATGGTGCCGGTTCTTTAAGGAAAACAATTTTCTAATCGGGATCAGTATCGACGGCCCTC
GCGAACTGCACGACGCCTACCGTGTGGACAAAAAAGGGGAGGGAAGCTTCGATAGGGTTATGAAGGGGCTTCGCCTGCTG
CAAAAACACGGGGTAGAATATAACGTCCTGACAACAGTTAACCGCACCAACGCCGATTACCCGCTGGAAGTCTACCGCTT
CCTGCGGGACGAAGCAGGGACAGACTGGATTCAGTTTATTCCGGTTGTTGAAAGGATCAATGGGGGAGGACGTACCCTTT
ACCAGAAAGGGGATAGGGTCTCGGACCGTTCTGTGAAGCCCGAGCAGTTTGGGAGTTTTCTGAGCTGCATTTTCGACGAA
TGGGTGAGAAATGATGTAGGTAGGATATTCGTGCAGACTTTTGAGGCTTCTGCACGCAGATGGATGGGATTGCCCTCAGG
GATGTGCGTTTTTGAAGAAACATGCGGGATTGGGCTTGCTCTTGAGCATAATGGAGATCTTTACTCATGTGACCATTTTG
TGGAGCCGGACTATCTGCTGGGCAATATTCTGGAAACAGAGATAGGAGAGCTTGCAGCATCGGAAAAGCAATACAGGTTC
GGGCAGGACAAACGTGATACTCTACCGCAGGTATGCCGGGAATGCGAGGTGTTCTTTGCCTGCAGGGGAGAATGTCCTAA
AAACCGCTTCCTGGCCACTCCTTCAGGAGAATCCGGCCTGAATTACCTCTGTAAGGGCTGGAAAGCTTTCTTCCAGCATG
TCGATTATCCGATGCAGATAATGGCAGGATTGATGCGCAGGGGTTACCCGGCATCAGAGGTGATGAGGATTCTGGCTCTT
GATGAAGCTTTTCAAAGGACAGGACGCAACGAACCCTGTCCCTGTGGCAGCGGGCTCAAGTTCAAACGCTGCCACGGACG
CAAGGATACCAGGGTAAAGAAAGAGGAAATGGGCATGTAA

Upstream 100 bases:

>100_bases
GAAGAAGAATAGGAAATGAATGCTGGATAAAACAAAAAGTGATGCATAGACTTTTTCCAGCCCACAGGAAAGTCTATTTT
ACTCAGGGAGAAAGTTCTGA

Downstream 100 bases:

>100_bases
TTTACGTGGATACTGTACATGCGAAAAATGCTGCGGAAAAAAATGGCACCATTAAAGAAAAATCCGATATCCGGTAAAGG
AGAGTCTTGAAGGAAGAGGG

Product: putative transcriptional regulator

Products: NA

Alternate protein names: AnSME; Chondroitin sulfate/heparin utilization regulation protein; Ser-type sulfatase-activating enzyme [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTIQNRLPHRIHVLAKPAGAICNLACKYCFFLDKELLYPGSRFRMSDEILENYIRQLIAAHSSPQVTVAWQGGEPTLMGV
DFYRRAIELQEKHRKPGMKFENTMQTNGTLLDDEWCRFFKENNFLIGISIDGPRELHDAYRVDKKGEGSFDRVMKGLRLL
QKHGVEYNVLTTVNRTNADYPLEVYRFLRDEAGTDWIQFIPVVERINGGGRTLYQKGDRVSDRSVKPEQFGSFLSCIFDE
WVRNDVGRIFVQTFEASARRWMGLPSGMCVFEETCGIGLALEHNGDLYSCDHFVEPDYLLGNILETEIGELAASEKQYRF
GQDKRDTLPQVCRECEVFFACRGECPKNRFLATPSGESGLNYLCKGWKAFFQHVDYPMQIMAGLMRRGYPASEVMRILAL
DEAFQRTGRNEPCPCGSGLKFKRCHGRKDTRVKKEEMGM

Sequences:

>Translated_439_residues
MTIQNRLPHRIHVLAKPAGAICNLACKYCFFLDKELLYPGSRFRMSDEILENYIRQLIAAHSSPQVTVAWQGGEPTLMGV
DFYRRAIELQEKHRKPGMKFENTMQTNGTLLDDEWCRFFKENNFLIGISIDGPRELHDAYRVDKKGEGSFDRVMKGLRLL
QKHGVEYNVLTTVNRTNADYPLEVYRFLRDEAGTDWIQFIPVVERINGGGRTLYQKGDRVSDRSVKPEQFGSFLSCIFDE
WVRNDVGRIFVQTFEASARRWMGLPSGMCVFEETCGIGLALEHNGDLYSCDHFVEPDYLLGNILETEIGELAASEKQYRF
GQDKRDTLPQVCRECEVFFACRGECPKNRFLATPSGESGLNYLCKGWKAFFQHVDYPMQIMAGLMRRGYPASEVMRILAL
DEAFQRTGRNEPCPCGSGLKFKRCHGRKDTRVKKEEMGM
>Mature_438_residues
TIQNRLPHRIHVLAKPAGAICNLACKYCFFLDKELLYPGSRFRMSDEILENYIRQLIAAHSSPQVTVAWQGGEPTLMGVD
FYRRAIELQEKHRKPGMKFENTMQTNGTLLDDEWCRFFKENNFLIGISIDGPRELHDAYRVDKKGEGSFDRVMKGLRLLQ
KHGVEYNVLTTVNRTNADYPLEVYRFLRDEAGTDWIQFIPVVERINGGGRTLYQKGDRVSDRSVKPEQFGSFLSCIFDEW
VRNDVGRIFVQTFEASARRWMGLPSGMCVFEETCGIGLALEHNGDLYSCDHFVEPDYLLGNILETEIGELAASEKQYRFG
QDKRDTLPQVCRECEVFFACRGECPKNRFLATPSGESGLNYLCKGWKAFFQHVDYPMQIMAGLMRRGYPASEVMRILALD
EAFQRTGRNEPCPCGSGLKFKRCHGRKDTRVKKEEMGM

Specific function: Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Links the heparin and the chondroitin sulfate utilization pathways which contribute to the colonization of the intestinal tract. May catalyze the activation of chondro-6- sulfatase, i

COG id: COG0641

COG function: function code R; Arylsulfatase regulator (Fe-S oxidoreductase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family [H]

Homologues:

Organism=Escherichia coli, GI48994973, Length=404, Percent_Identity=49.7524752475247, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI87081923, Length=391, Percent_Identity=41.4322250639386, Blast_Score=316, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 50429; Mature: 50298

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQNRLPHRIHVLAKPAGAICNLACKYCFFLDKELLYPGSRFRMSDEILENYIRQLIAA
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
HSSPQVTVAWQGGEPTLMGVDFYRRAIELQEKHRKPGMKFENTMQTNGTLLDDEWCRFFK
CCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECHHHHHHHH
ENNFLIGISIDGPRELHDAYRVDKKGEGSFDRVMKGLRLLQKHGVEYNVLTTVNRTNADY
CCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
PLEVYRFLRDEAGTDWIQFIPVVERINGGGRTLYQKGDRVSDRSVKPEQFGSFLSCIFDE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHH
WVRNDVGRIFVQTFEASARRWMGLPSGMCVFEETCGIGLALEHNGDLYSCDHFVEPDYLL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHCCCCEEEEECCCCEEECCCCCCCHHHH
GNILETEIGELAASEKQYRFGQDKRDTLPQVCRECEVFFACRGECPKNRFLATPSGESGL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEECCCCCCHH
NYLCKGWKAFFQHVDYPMQIMAGLMRRGYPASEVMRILALDEAFQRTGRNEPCPCGSGLK
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FKRCHGRKDTRVKKEEMGM
CHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TIQNRLPHRIHVLAKPAGAICNLACKYCFFLDKELLYPGSRFRMSDEILENYIRQLIAA
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
HSSPQVTVAWQGGEPTLMGVDFYRRAIELQEKHRKPGMKFENTMQTNGTLLDDEWCRFFK
CCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECHHHHHHHH
ENNFLIGISIDGPRELHDAYRVDKKGEGSFDRVMKGLRLLQKHGVEYNVLTTVNRTNADY
CCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCC
PLEVYRFLRDEAGTDWIQFIPVVERINGGGRTLYQKGDRVSDRSVKPEQFGSFLSCIFDE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHH
WVRNDVGRIFVQTFEASARRWMGLPSGMCVFEETCGIGLALEHNGDLYSCDHFVEPDYLL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHCCCCEEEEECCCCEEECCCCCCCHHHH
GNILETEIGELAASEKQYRFGQDKRDTLPQVCRECEVFFACRGECPKNRFLATPSGESGL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEECCCCCCHH
NYLCKGWKAFFQHVDYPMQIMAGLMRRGYPASEVMRILALDEAFQRTGRNEPCPCGSGLK
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FKRCHGRKDTRVKKEEMGM
CHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1429442; 12663928 [H]