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The map label for this gene is aslA [H]

Identifier: 21227994

GI number: 21227994

Start: 2247365

End: 2248903

Strand: Reverse

Name: aslA [H]

Synonym: MM_1892

Alternate gene names: 21227994

Gene position: 2248903-2247365 (Counterclockwise)

Preceding gene: 21227995

Following gene: 21227993

Centisome position: 54.9

GC content: 50.68

Gene sequence:

>1539_bases
ATGGGAGAAAAGAAACCAAATATTCTGGTCATCTGGGGAGATGACATAGGTATCAGCAATCTCAGCTGCTACAGTGATGG
ATTGATGGGGTACAGAACACCTAACATAGACCGCATAGCCAACGAAGGCATGAGGTTCACAGACTCCTATGGAGAACAGA
GCTGCACAGCCGGACGTGCAGCGTTTATTACAGGCCAGAGCCCTTTCAGGACAGGACTGAGCAAAGTAGGTCTGCCCGGG
GCAAAGACAGGATTACAGCACGAAGACCCTACCATTGCCGAACTTCTGAAAGCCCAGGGTTATGCCACAGGCCAGTTCGG
CAAGAACCACTTTGGAGACCGGAACGAGTACCTGCCTACAGTTCATGGTTTTGATGAATTCTTTGGAAACCTCTACCACC
TGAACGCAGAAGAGGAGCCTGAACTACCTGACTATCCTCCCGGAGAGGACTTCCCACTTTTCAGGGAACGATTTGGTCCG
AGGGGAGTGATGCATTCCTGGGCTACTGATGAAGATGATCCTACCGAGGACCCGCGCTGGGGTCGCGTGGGCAGACAAAA
GATAGAAGACACAGGTCCGCTGAGCAGGAAACGCATGGAGAAGGTTGATCTTGAGTTCATAGAGGCAGCCATTGACTTCA
TTAAACGCCAAAAAGAGGCTGGTAAGCCTTTTTTTGTATGGCTCAACACCACCTGGATGCATTTTAGAGTGCATGTCCCT
GAAGAGATCAGAGGTCAGGCAGGGCGCTGGCAGTCGGAGTATCACGATGCAATGATCGAGCACGACAGGCAGGTTGGCAT
GATGCTTGATCTGCTTGACGAGCTGGGTATTGCCGAAGATACCATCGTTTTGTACAGCACGGACAACGGACCTCATATGA
ATTCCTGGCCCGATGCAGCCATGACCCCCTTCCGTTGCGAGAAGAATTCAAATTGGGAAGGTGCTTTCCGCGTTCCTGAA
GTCATGCGCTGGCCGGGTAAGATACCTGCAGGCGTTGTATCCAACGAGATCATAAGCCACATGGACTGGCTGCCCACTTT
CCTCTCAGCGGCAGGGGTGCCGGATATTAAGGAGAAACTTAAGAAAGGATACAAGGTCGGTGAAAAGAACTTCAAGGTGC
ATCTCGATGGTTATAACTTTTTACCCTGTCTGACAGGCAAAGAGAAAAAATCCCCACGCATTGAGTTCTTTTACTTCTCC
GATGATGGGGATCTGGTTGCAGCCCGGTATGACAACTGGAAACTGGTGTTCATGGAACAGCGTGCTGTCGGGACCCTGCA
GGTATGGATTGAGCCCTTTGTACCTCTGCGTGTTCCAAAGATATTCAATCTTCGAACAGACCCGTATGAGCGCGCAGATA
TGACCTCCAATACCTACTATGACTGGATGCTTGACCATGCTTTCCTTCTGATACCGGCCCAAAAAATAGTTGGCGACTTT
TTGTCGACTTTCGTAGAATTCCCGCCGCGCCAGAAGGCAGCCAGCTTTACCATAAACAGGGTGATGGAAAAGCTCCAGGA
GGGGATCGGCAGTAACTGA

Upstream 100 bases:

>100_bases
ATATCCGGTAAAGGAGAGTCTTGAAGGAAGAGGGGCCGGAAATACATTAGCACGCGATAATTCTGGTTGTCGATAATCAA
TTAATAAAGGAGAAGAAACA

Downstream 100 bases:

>100_bases
GGGGTTAGAGATACATTAAGGTCTTTGTGCGCTGGCTCTTTGAGCCAGCTGGCAACTTTAATACATATTACATACCTGAA
AAAGCTAGCCGGAACTTACA

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MGEKKPNILVIWGDDIGISNLSCYSDGLMGYRTPNIDRIANEGMRFTDSYGEQSCTAGRAAFITGQSPFRTGLSKVGLPG
AKTGLQHEDPTIAELLKAQGYATGQFGKNHFGDRNEYLPTVHGFDEFFGNLYHLNAEEEPELPDYPPGEDFPLFRERFGP
RGVMHSWATDEDDPTEDPRWGRVGRQKIEDTGPLSRKRMEKVDLEFIEAAIDFIKRQKEAGKPFFVWLNTTWMHFRVHVP
EEIRGQAGRWQSEYHDAMIEHDRQVGMMLDLLDELGIAEDTIVLYSTDNGPHMNSWPDAAMTPFRCEKNSNWEGAFRVPE
VMRWPGKIPAGVVSNEIISHMDWLPTFLSAAGVPDIKEKLKKGYKVGEKNFKVHLDGYNFLPCLTGKEKKSPRIEFFYFS
DDGDLVAARYDNWKLVFMEQRAVGTLQVWIEPFVPLRVPKIFNLRTDPYERADMTSNTYYDWMLDHAFLLIPAQKIVGDF
LSTFVEFPPRQKAASFTINRVMEKLQEGIGSN

Sequences:

>Translated_512_residues
MGEKKPNILVIWGDDIGISNLSCYSDGLMGYRTPNIDRIANEGMRFTDSYGEQSCTAGRAAFITGQSPFRTGLSKVGLPG
AKTGLQHEDPTIAELLKAQGYATGQFGKNHFGDRNEYLPTVHGFDEFFGNLYHLNAEEEPELPDYPPGEDFPLFRERFGP
RGVMHSWATDEDDPTEDPRWGRVGRQKIEDTGPLSRKRMEKVDLEFIEAAIDFIKRQKEAGKPFFVWLNTTWMHFRVHVP
EEIRGQAGRWQSEYHDAMIEHDRQVGMMLDLLDELGIAEDTIVLYSTDNGPHMNSWPDAAMTPFRCEKNSNWEGAFRVPE
VMRWPGKIPAGVVSNEIISHMDWLPTFLSAAGVPDIKEKLKKGYKVGEKNFKVHLDGYNFLPCLTGKEKKSPRIEFFYFS
DDGDLVAARYDNWKLVFMEQRAVGTLQVWIEPFVPLRVPKIFNLRTDPYERADMTSNTYYDWMLDHAFLLIPAQKIVGDF
LSTFVEFPPRQKAASFTINRVMEKLQEGIGSN
>Mature_511_residues
GEKKPNILVIWGDDIGISNLSCYSDGLMGYRTPNIDRIANEGMRFTDSYGEQSCTAGRAAFITGQSPFRTGLSKVGLPGA
KTGLQHEDPTIAELLKAQGYATGQFGKNHFGDRNEYLPTVHGFDEFFGNLYHLNAEEEPELPDYPPGEDFPLFRERFGPR
GVMHSWATDEDDPTEDPRWGRVGRQKIEDTGPLSRKRMEKVDLEFIEAAIDFIKRQKEAGKPFFVWLNTTWMHFRVHVPE
EIRGQAGRWQSEYHDAMIEHDRQVGMMLDLLDELGIAEDTIVLYSTDNGPHMNSWPDAAMTPFRCEKNSNWEGAFRVPEV
MRWPGKIPAGVVSNEIISHMDWLPTFLSAAGVPDIKEKLKKGYKVGEKNFKVHLDGYNFLPCLTGKEKKSPRIEFFYFSD
DGDLVAARYDNWKLVFMEQRAVGTLQVWIEPFVPLRVPKIFNLRTDPYERADMTSNTYYDWMLDHAFLLIPAQKIVGDFL
STFVEFPPRQKAASFTINRVMEKLQEGIGSN

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=430, Percent_Identity=30.9302325581395, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI146229329, Length=430, Percent_Identity=30.9302325581395, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI6005990, Length=430, Percent_Identity=30.9302325581395, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI146229324, Length=430, Percent_Identity=30.9302325581395, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI4503899, Length=511, Percent_Identity=29.1585127201566, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI45430057, Length=466, Percent_Identity=27.8969957081545, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI31742482, Length=525, Percent_Identity=27.4285714285714, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI58743319, Length=444, Percent_Identity=29.7297297297297, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI71852584, Length=521, Percent_Identity=26.1036468330134, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI146229327, Length=356, Percent_Identity=28.0898876404494, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI109389362, Length=503, Percent_Identity=24.6520874751491, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI38569407, Length=410, Percent_Identity=28.5365853658537, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI38569405, Length=410, Percent_Identity=28.5365853658537, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI157266309, Length=147, Percent_Identity=41.4965986394558, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI71852586, Length=152, Percent_Identity=38.8157894736842, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI53831991, Length=210, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI59797060, Length=486, Percent_Identity=23.2510288065844, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790233, Length=502, Percent_Identity=28.2868525896414, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI115533416, Length=470, Percent_Identity=25.7446808510638, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559078, Length=143, Percent_Identity=36.3636363636364, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666175, Length=444, Percent_Identity=27.9279279279279, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI281366397, Length=538, Percent_Identity=25.4646840148699, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281366395, Length=538, Percent_Identity=25.4646840148699, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24666163, Length=538, Percent_Identity=25.4646840148699, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281363223, Length=426, Percent_Identity=25.1173708920188, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24666109, Length=437, Percent_Identity=25.4004576659039, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 58521; Mature: 58390

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKKPNILVIWGDDIGISNLSCYSDGLMGYRTPNIDRIANEGMRFTDSYGEQSCTAGRA
CCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCEECCCCCCCCCCCCCE
AFITGQSPFRTGLSKVGLPGAKTGLQHEDPTIAELLKAQGYATGQFGKNHFGDRNEYLPT
EEEECCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VHGFDEFFGNLYHLNAEEEPELPDYPPGEDFPLFRERFGPRGVMHSWATDEDDPTEDPRW
CCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GRVGRQKIEDTGPLSRKRMEKVDLEFIEAAIDFIKRQKEAGKPFFVWLNTTWMHFRVHVP
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEEEEEECC
EEIRGQAGRWQSEYHDAMIEHDRQVGMMLDLLDELGIAEDTIVLYSTDNGPHMNSWPDAA
HHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
MTPFRCEKNSNWEGAFRVPEVMRWPGKIPAGVVSNEIISHMDWLPTFLSAAGVPDIKEKL
CCCEEECCCCCCCCEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KKGYKVGEKNFKVHLDGYNFLPCLTGKEKKSPRIEFFYFSDDGDLVAARYDNWKLVFMEQ
HHCCCCCCCCEEEEECCCCEECCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEEEC
RAVGTLQVWIEPFVPLRVPKIFNLRTDPYERADMTSNTYYDWMLDHAFLLIPAQKIVGDF
CCCCEEEEEECCCCCCCCCCEECCCCCCCHHHCCCCCCCHHHHHHCEEEEEEHHHHHHHH
LSTFVEFPPRQKAASFTINRVMEKLQEGIGSN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GEKKPNILVIWGDDIGISNLSCYSDGLMGYRTPNIDRIANEGMRFTDSYGEQSCTAGRA
CCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCEECCCCCCCCCCCCCE
AFITGQSPFRTGLSKVGLPGAKTGLQHEDPTIAELLKAQGYATGQFGKNHFGDRNEYLPT
EEEECCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VHGFDEFFGNLYHLNAEEEPELPDYPPGEDFPLFRERFGPRGVMHSWATDEDDPTEDPRW
CCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GRVGRQKIEDTGPLSRKRMEKVDLEFIEAAIDFIKRQKEAGKPFFVWLNTTWMHFRVHVP
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEEEEEECC
EEIRGQAGRWQSEYHDAMIEHDRQVGMMLDLLDELGIAEDTIVLYSTDNGPHMNSWPDAA
HHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
MTPFRCEKNSNWEGAFRVPEVMRWPGKIPAGVVSNEIISHMDWLPTFLSAAGVPDIKEKL
CCCEEECCCCCCCCEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KKGYKVGEKNFKVHLDGYNFLPCLTGKEKKSPRIEFFYFSDDGDLVAARYDNWKLVFMEQ
HHCCCCCCCCEEEEECCCCEECCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEEEC
RAVGTLQVWIEPFVPLRVPKIFNLRTDPYERADMTSNTYYDWMLDHAFLLIPAQKIVGDF
CCCCEEEEEECCCCCCCCCCEECCCCCCCHHHCCCCCCCHHHHHHCEEEEEEHHHHHHHH
LSTFVEFPPRQKAASFTINRVMEKLQEGIGSN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]