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The map label for this gene is pyrK

Identifier: 21227848

GI number: 21227848

Start: 2087875

End: 2088654

Strand: Direct

Name: pyrK

Synonym: MM_1746

Alternate gene names: 21227848

Gene position: 2087875-2088654 (Clockwise)

Preceding gene: 161485673

Following gene: 21227849

Centisome position: 50.97

GC content: 48.33

Gene sequence:

>780_bases
ATGCTTCCTCTTAATGCTACCATAACACAGATAATTGAAGAATCCCCTCTGATCAGGACTTTTTTCTTTGACCACAAATT
TGAGGATATGGAGCCGGGCCAGTTTGTAATGGTCTGGGTCAGGGGTGTGGATGAGGTTCCCATGGGGCTCTCAAGAAATA
ATTCCATAACCGTCCAGAAAGTGGGAGAGGCGACTTCAAAGCTCTTTGAGTTAAAAGAAGGAGACTCTTTCGGGCTAAGG
GGTCCTTTTGGAAAAGGTTTTACCCTTCCTGCAAAAGGAGAAAAGGTTCTTATTATAGCTGGCGGGGTCGGAGCTGCTCC
TCTTTCACCGTATGCCGAAGCAGCTTTTGCGGCAGGTGCGGAAGTGAATACCGTTCTCGGGGCACGGAGTGAAGAGCACC
TGCTTTTTGAAGGTCGTTTCGAAGCTCTCGGAACTGTTTATGTGTCTACTGATGACGGTTCAAAAGGATTTAAAGGGTTT
GTGACTGATGTACTCAAAAACCTTGATGTTACATCCTATGACAGAATTGCGGTCTGCGGACCTGAAATAATGATGGCTTC
GGTTTTCAGGTTCCTTGAAGAGAGAGAAGTGCTGGAAAAATCAGAGTTCAGCCTTCACCGTTATTTCAAATGCGGTATCG
GGGTATGCGGGGCGTGCTGCATAGACAGGTCCGGCCTCAGGGTCTGCAAGGACGGGCCTGTGTTTTCCGGCACTCAGCTC
ATAGGTTCCGAGCTCGGGAAATACTCACGGGACGCCAGCGGGCGAAGAGTTAAAATTTAA

Upstream 100 bases:

>100_bases
GTATATTCTCTGAAATAGGCAAAGGAATAGAAGCTTTCCTCAAAAGAAAAGGCTATTCTGATATAAAGAAAATTACAGGG
CTTGCCCACGAGATGGTCTG

Downstream 100 bases:

>100_bases
GTTTGGATATATCCTCTTAAAAAATGAAAGAAAGCGGAGTGAAAGACCCGCAAAAATAGGATAAGGAAGGCGAAGATATG
ATTGGTAGGTTCAGGTCAGG

Product: dihydroorotate dehydrogenase electron transfer subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MLPLNATITQIIEESPLIRTFFFDHKFEDMEPGQFVMVWVRGVDEVPMGLSRNNSITVQKVGEATSKLFELKEGDSFGLR
GPFGKGFTLPAKGEKVLIIAGGVGAAPLSPYAEAAFAAGAEVNTVLGARSEEHLLFEGRFEALGTVYVSTDDGSKGFKGF
VTDVLKNLDVTSYDRIAVCGPEIMMASVFRFLEEREVLEKSEFSLHRYFKCGIGVCGACCIDRSGLRVCKDGPVFSGTQL
IGSELGKYSRDASGRRVKI

Sequences:

>Translated_259_residues
MLPLNATITQIIEESPLIRTFFFDHKFEDMEPGQFVMVWVRGVDEVPMGLSRNNSITVQKVGEATSKLFELKEGDSFGLR
GPFGKGFTLPAKGEKVLIIAGGVGAAPLSPYAEAAFAAGAEVNTVLGARSEEHLLFEGRFEALGTVYVSTDDGSKGFKGF
VTDVLKNLDVTSYDRIAVCGPEIMMASVFRFLEEREVLEKSEFSLHRYFKCGIGVCGACCIDRSGLRVCKDGPVFSGTQL
IGSELGKYSRDASGRRVKI
>Mature_259_residues
MLPLNATITQIIEESPLIRTFFFDHKFEDMEPGQFVMVWVRGVDEVPMGLSRNNSITVQKVGEATSKLFELKEGDSFGLR
GPFGKGFTLPAKGEKVLIIAGGVGAAPLSPYAEAAFAAGAEVNTVLGARSEEHLLFEGRFEALGTVYVSTDDGSKGFKGF
VTDVLKNLDVTSYDRIAVCGPEIMMASVFRFLEEREVLEKSEFSLHRYFKCGIGVCGACCIDRSGLRVCKDGPVFSGTQL
IGSELGKYSRDASGRRVKI

Specific function: Is responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+)

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRK_METMA (Q8PW55)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633770.1
- ProteinModelPortal:   Q8PW55
- SMR:   Q8PW55
- GeneID:   1480088
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1746
- NMPDR:   fig|192952.1.peg.1746
- HOGENOM:   HBG730970
- OMA:   RYMKCGI
- ProtClustDB:   PRK00054
- BioCyc:   MMAZ192952:MM1746-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01211_A
- InterPro:   IPR012165
- InterPro:   IPR019480
- InterPro:   IPR017927
- InterPro:   IPR001433
- InterPro:   IPR017938
- PIRSF:   PIRSF006816

Pfam domain/function: PF10418 DHODB_Fe-S_bind; PF00175 NAD_binding_1; SSF63380 Riboflavin_synthase_like_b-brl

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28188; Mature: 28188

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00197 2FE2S_FER_1; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLNATITQIIEESPLIRTFFFDHKFEDMEPGQFVMVWVRGVDEVPMGLSRNNSITVQK
CCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
VGEATSKLFELKEGDSFGLRGPFGKGFTLPAKGEKVLIIAGGVGAAPLSPYAEAAFAAGA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCC
EVNTVLGARSEEHLLFEGRFEALGTVYVSTDDGSKGFKGFVTDVLKNLDVTSYDRIAVCG
CHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
PEIMMASVFRFLEEREVLEKSEFSLHRYFKCGIGVCGACCIDRSGLRVCKDGPVFSGTQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCHHH
IGSELGKYSRDASGRRVKI
HHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MLPLNATITQIIEESPLIRTFFFDHKFEDMEPGQFVMVWVRGVDEVPMGLSRNNSITVQK
CCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
VGEATSKLFELKEGDSFGLRGPFGKGFTLPAKGEKVLIIAGGVGAAPLSPYAEAAFAAGA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCC
EVNTVLGARSEEHLLFEGRFEALGTVYVSTDDGSKGFKGFVTDVLKNLDVTSYDRIAVCG
CHHHHHCCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
PEIMMASVFRFLEEREVLEKSEFSLHRYFKCGIGVCGACCIDRSGLRVCKDGPVFSGTQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCHHH
IGSELGKYSRDASGRRVKI
HHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824