Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 161485673

GI number: 161485673

Start: 2086970

End: 2087875

Strand: Direct

Name: pyrD

Synonym: MM_1745

Alternate gene names: 161485673

Gene position: 2086970-2087875 (Clockwise)

Preceding gene: 21227846

Following gene: 21227848

Centisome position: 50.95

GC content: 51.88

Gene sequence:

>906_bases
ATGTATACTCTTACCGGACTTAAATTAAAAAATCCCACTATTCTTGCAGCCGGGGTGCTCGGGACAACCGGGGCTTCCCT
CTGCAGGGTCGCACGTGAAGGGGGAGCTGGTGCAGTTGTGACCAAATCCATAGGTCCTGCTCCCAAAACCGGTCATCCAA
ACCCGAGCATGATTGAGCTGGACTGCGGCTTTTTAAATGCCATGGGGCTTCCAAACCCTTCCTATCCCGGCTTCCTCCAG
GAGCTGGAGTTTGCAAAAGAAAACTCTGATGCTCCGGTAATTGCAAGCATTTTCGGGGGCACCCCTTCCGAATTCGCTGA
AGTTGCAGAGGGGCTGCTCCCGGCAAAGCCCGATGCTTTCGAACTTAACGTGAGCTGCCCCCATGCAGAGGGTTACGGGG
CTGCAATAGGTTCCAACCCCTGCCTCGTTGAAGCAGTTACGGCGGCGGTAAAGGATGTTGTCAATGTACCTGTCTGGGTC
AAGCTGACTCCCAATGTTGCGGACATTACATGCATTGGAAATGCAGCCGAGTCCGGGGGCGCGGACGCCGTTGTTGCGAT
CAACACGGTAAAGGGAATGGCTATTGACATTGAATCCGGGTACCCTGTGCTTGGAAACCGTTCAGGAGGGCTTTCGGGAA
AAGCTGTTAAGCCCGTAGCAGTAAAATGTGTTTATGACCTTTTCACTGCCCTGGAAATCCCGGTAATCGGCGTGGGAGGA
GTTTCTTCCTGGGAAGACGCTGTGGAAATGATAATGGCAGGTGCAGCCGCTGTTCAGGTTGGGTCTGCGGTATATGACAG
GGTAGGTATATTCTCTGAAATAGGCAAAGGAATAGAAGCTTTCCTCAAAAGAAAAGGCTATTCTGATATAAAGAAAATTA
CAGGGCTTGCCCACGAGATGGTCTGA

Upstream 100 bases:

>100_bases
CTGAGGAAGCGCTCCTTCAGATTTCCAGAGGTGCCGATTCCGAAAATTCCTGTGATTATTGATGCAGAAACTGCCTGCGG
GCAGGAAACGGAGTTATTTA

Downstream 100 bases:

>100_bases
TGCTTCCTCTTAATGCTACCATAACACAGATAATTGAAGAATCCCCTCTGATCAGGACTTTTTTCTTTGACCACAAATTT
GAGGATATGGAGCCGGGCCA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MYTLTGLKLKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHPNPSMIELDCGFLNAMGLPNPSYPGFLQ
ELEFAKENSDAPVIASIFGGTPSEFAEVAEGLLPAKPDAFELNVSCPHAEGYGAAIGSNPCLVEAVTAAVKDVVNVPVWV
KLTPNVADITCIGNAAESGGADAVVAINTVKGMAIDIESGYPVLGNRSGGLSGKAVKPVAVKCVYDLFTALEIPVIGVGG
VSSWEDAVEMIMAGAAAVQVGSAVYDRVGIFSEIGKGIEAFLKRKGYSDIKKITGLAHEMV

Sequences:

>Translated_301_residues
MYTLTGLKLKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHPNPSMIELDCGFLNAMGLPNPSYPGFLQ
ELEFAKENSDAPVIASIFGGTPSEFAEVAEGLLPAKPDAFELNVSCPHAEGYGAAIGSNPCLVEAVTAAVKDVVNVPVWV
KLTPNVADITCIGNAAESGGADAVVAINTVKGMAIDIESGYPVLGNRSGGLSGKAVKPVAVKCVYDLFTALEIPVIGVGG
VSSWEDAVEMIMAGAAAVQVGSAVYDRVGIFSEIGKGIEAFLKRKGYSDIKKITGLAHEMV
>Mature_301_residues
MYTLTGLKLKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHPNPSMIELDCGFLNAMGLPNPSYPGFLQ
ELEFAKENSDAPVIASIFGGTPSEFAEVAEGLLPAKPDAFELNVSCPHAEGYGAAIGSNPCLVEAVTAAVKDVVNVPVWV
KLTPNVADITCIGNAAESGGADAVVAINTVKGMAIDIESGYPVLGNRSGGLSGKAVKPVAVKCVYDLFTALEIPVIGVGG
VSSWEDAVEMIMAGAAAVQVGSAVYDRVGIFSEIGKGIEAFLKRKGYSDIKKITGLAHEMV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=316, Percent_Identity=31.3291139240506, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI45006951, Length=319, Percent_Identity=26.6457680250784, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI87082059, Length=320, Percent_Identity=32.8125, Blast_Score=154, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71984108, Length=316, Percent_Identity=31.6455696202532, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=26.791277258567, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=297, Percent_Identity=31.6498316498317, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640763, Length=288, Percent_Identity=34.375, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18858217, Length=288, Percent_Identity=34.375, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI281361352, Length=314, Percent_Identity=26.7515923566879, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137316, Length=314, Percent_Identity=26.7515923566879, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_METMA (Q8PW56)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633769.2
- ProteinModelPortal:   Q8PW56
- SMR:   Q8PW56
- GeneID:   1480087
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1745
- NMPDR:   fig|192952.1.peg.1745
- HOGENOM:   HBG472415
- OMA:   VTKSIGP
- ProtClustDB:   PRK07259
- BioCyc:   MMAZ192952:MM1745-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_A
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 30733; Mature: 30733

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTLTGLKLKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHPNPSMIEL
CEEECCEEECCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEE
DCGFLNAMGLPNPSYPGFLQELEFAKENSDAPVIASIFGGTPSEFAEVAEGLLPAKPDAF
ECCCHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCE
ELNVSCPHAEGYGAAIGSNPCLVEAVTAAVKDVVNVPVWVKLTPNVADITCIGNAAESGG
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCC
ADAVVAINTVKGMAIDIESGYPVLGNRSGGLSGKAVKPVAVKCVYDLFTALEIPVIGVGG
CCEEEEEEECCCEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECC
VSSWEDAVEMIMAGAAAVQVGSAVYDRVGIFSEIGKGIEAFLKRKGYSDIKKITGLAHEM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
V
C
>Mature Secondary Structure
MYTLTGLKLKNPTILAAGVLGTTGASLCRVAREGGAGAVVTKSIGPAPKTGHPNPSMIEL
CEEECCEEECCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEE
DCGFLNAMGLPNPSYPGFLQELEFAKENSDAPVIASIFGGTPSEFAEVAEGLLPAKPDAF
ECCCHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCE
ELNVSCPHAEGYGAAIGSNPCLVEAVTAAVKDVVNVPVWVKLTPNVADITCIGNAAESGG
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCC
ADAVVAINTVKGMAIDIESGYPVLGNRSGGLSGKAVKPVAVKCVYDLFTALEIPVIGVGG
CCEEEEEEECCCEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECC
VSSWEDAVEMIMAGAAAVQVGSAVYDRVGIFSEIGKGIEAFLKRKGYSDIKKITGLAHEM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824