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The map label for this gene is ribB

Identifier: 21227812

GI number: 21227812

Start: 2052196

End: 2052939

Strand: Direct

Name: ribB

Synonym: MM_1710

Alternate gene names: 21227812

Gene position: 2052196-2052939 (Clockwise)

Preceding gene: 21227811

Following gene: 21227813

Centisome position: 50.1

GC content: 48.92

Gene sequence:

>744_bases
ATGAGCGAGAACATGGCCTATGAATGTCTGAAATATAGCAATGAAAATATTAACAGGGCTCTGGAAGCCCTGCGTGCCGG
AAAAATGATCCAGATCTATGACTCGGATTCAAGAGAAGGAGAAACAGATCTTGTAATTCCTGCGAAAGCTGTCACTTATA
CTGATGTGAAATGGATGCGGAAAGATGCCGGTGGTCTTATCTGCGTGGCAGTGGACCCGGTGGCGTCAAAACAGCTTAAA
TTGCCGTTCATGGCAGACCTTGTAAGGGAAGCCAGCAAGACCAGCGACTCCCTTGGGGAAGTTGTTGAAAAAGACGGAGA
CCTCAAATACGATGCCCATTCCTCTTTCTCTCTCTGGGTCAACCACAGGGACACAAGGACAGGCATTCCTGACATTGAAA
GAGCCCTTACAATCAGGAAAATAGGTGAGATCACAGAAGAATCCCTTTCAGGAAACGGGGTCCGTTTTGGAAACGAGTTC
AGGACTCCAGGGCACGTTGCTCTCCTCAGGGCTGCCGAAGGGCTCCTTGATGAGCGCATGGGCCAGACAGAACTTTCGGT
TGCACTTGCCCGTATGGCAGGAATAACCCCTGCGATGGTTGTCTGTGAAATGCTGGACGATGACAGCGGGAAAGCCCTTT
CAAAAGAAAAATCAAAAGAATACGGAAAAGAACACGGGCTTGTCTTCCTCGAAGGGCGGGAAATAGTTGAAGCTTATTTG
CTCTGGGCAGGTACAGATTGCTGA

Upstream 100 bases:

>100_bases
TTGAGATTATTGCACCGGTAAAACTCAGGGATGCCCTGAAATTGAAAGATGGAGACAGAGTTGTGACACAGCTGAAAAAG
CAGGGTATGGAGGGACAGAA

Downstream 100 bases:

>100_bases
AAATCTTCCCTGTTTCTCATTTTTTTCTTTTTGATTCGTTATCTTTTCCAATTCTTTTTTTAAACTTCTCTATCCTTCTC
AATTCTTTTTTCAAATTCTT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSENMAYECLKYSNENINRALEALRAGKMIQIYDSDSREGETDLVIPAKAVTYTDVKWMRKDAGGLICVAVDPVASKQLK
LPFMADLVREASKTSDSLGEVVEKDGDLKYDAHSSFSLWVNHRDTRTGIPDIERALTIRKIGEITEESLSGNGVRFGNEF
RTPGHVALLRAAEGLLDERMGQTELSVALARMAGITPAMVVCEMLDDDSGKALSKEKSKEYGKEHGLVFLEGREIVEAYL
LWAGTDC

Sequences:

>Translated_247_residues
MSENMAYECLKYSNENINRALEALRAGKMIQIYDSDSREGETDLVIPAKAVTYTDVKWMRKDAGGLICVAVDPVASKQLK
LPFMADLVREASKTSDSLGEVVEKDGDLKYDAHSSFSLWVNHRDTRTGIPDIERALTIRKIGEITEESLSGNGVRFGNEF
RTPGHVALLRAAEGLLDERMGQTELSVALARMAGITPAMVVCEMLDDDSGKALSKEKSKEYGKEHGLVFLEGREIVEAYL
LWAGTDC
>Mature_246_residues
SENMAYECLKYSNENINRALEALRAGKMIQIYDSDSREGETDLVIPAKAVTYTDVKWMRKDAGGLICVAVDPVASKQLKL
PFMADLVREASKTSDSLGEVVEKDGDLKYDAHSSFSLWVNHRDTRTGIPDIERALTIRKIGEITEESLSGNGVRFGNEFR
TPGHVALLRAAEGLLDERMGQTELSVALARMAGITPAMVVCEMLDDDSGKALSKEKSKEYGKEHGLVFLEGREIVEAYLL
WAGTDC

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHBP synthase family

Homologues:

Organism=Escherichia coli, GI1789420, Length=223, Percent_Identity=26.0089686098655, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320695, Length=226, Percent_Identity=25.6637168141593, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBB_METMA (Q8PW86)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633734.1
- ProteinModelPortal:   Q8PW86
- SMR:   Q8PW86
- GeneID:   1480052
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1710
- NMPDR:   fig|192952.1.peg.1710
- HOGENOM:   HBG735778
- OMA:   RGHTEAT
- ProtClustDB:   CLSK634377
- BioCyc:   MMAZ192952:MM1710-MONOMER
- BRENDA:   4.1.99.12
- HAMAP:   MF_00180
- InterPro:   IPR017945
- InterPro:   IPR000422
- Gene3D:   G3DSA:3.90.870.10
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12

Molecular weight: Translated: 27268; Mature: 27137

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: BINDING 43-43 BINDING 203-203

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENMAYECLKYSNENINRALEALRAGKMIQIYDSDSREGETDLVIPAKAVTYTDVKWMR
CCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCEEHHHHHHHH
KDAGGLICVAVDPVASKQLKLPFMADLVREASKTSDSLGEVVEKDGDLKYDAHSSFSLWV
HCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEECCCCCEEEEE
NHRDTRTGIPDIERALTIRKIGEITEESLSGNGVRFGNEFRTPGHVALLRAAEGLLDERM
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHC
GQTELSVALARMAGITPAMVVCEMLDDDSGKALSKEKSKEYGKEHGLVFLEGREIVEAYL
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHH
LWAGTDC
HHCCCCC
>Mature Secondary Structure 
SENMAYECLKYSNENINRALEALRAGKMIQIYDSDSREGETDLVIPAKAVTYTDVKWMR
CCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCEEHHHHHHHH
KDAGGLICVAVDPVASKQLKLPFMADLVREASKTSDSLGEVVEKDGDLKYDAHSSFSLWV
HCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEECCCCCEEEEE
NHRDTRTGIPDIERALTIRKIGEITEESLSGNGVRFGNEFRTPGHVALLRAAEGLLDERM
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHC
GQTELSVALARMAGITPAMVVCEMLDDDSGKALSKEKSKEYGKEHGLVFLEGREIVEAYL
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHH
LWAGTDC
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12125824