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The map label for this gene is mtrE

Identifier: 21227649

GI number: 21227649

Start: 1844068

End: 1844982

Strand: Reverse

Name: mtrE

Synonym: MM_1547

Alternate gene names: 21227649

Gene position: 1844982-1844068 (Counterclockwise)

Preceding gene: 21227651

Following gene: 21227648

Centisome position: 45.04

GC content: 46.34

Gene sequence:

>915_bases
ATGGAACCACTCATAGGCATGGGAGTGCTTGCACTTATTGGAGTGGCTGCGACCATTGCAGGTGCTTCAGAGGACCTGGA
ATCTGACATAGGTTCGCAGAGCAACCCTAACTCTCAGGTGCAGTTAGCTCCCCAAATGATGTTTCCCCACAGAATATTTA
ACAAAGCGATATCTGGAGAACCACCATCCAACGCATTAATGTGTTCGATAGGTGCAGCCATTGCGACAGTATTAATAAGT
GAATTTACAGTATCCCCACTTTTTGCACTGGTATTTGGTTCCGTTATTGCAGCATCCGTACACGCTACTTTTGCGGTAAC
TGCTACAATGGGCAGATGTGCCAGTCAGAGTCGGTTCAAGCAGCCGATTTATCTGGATATGATAAGAAGTCATACCCCGG
CAATTATGGGATATGCGTTCATAACAACCTTTTGTGTTCTAATAGTATCGTACTTGATGACCGTTGTACTCGGGCACCCC
TTCCCGCTGACTATGCTAGCTTTTATCTGGGGTATTACAATAGGTGCAATAGGTTCTTCAACCGGCGACGTCCACTATGG
TGCTGAACGTGAATTCCAGCAGTTTGAATTTGGTTCAGGGCTGAACGCCTCAAACTCAGGAAACATTGTAAGATATGCCG
AGTCCGGCCTCAGGAATGGGTTCGACAACTCCTGGTTCTGCTCAAAGTTCGGCGGACCTACCACAGGAATTGCTTTTGGT
ATGACCGTATTCCTTGGAAGCTGGATAACCACTATTTTTGATCCTGCACAAGGTCTGTCCATGGGATGGCTCTCTGTTAT
TGCAGGTGTTATTATCGTCCTTATTTTAATTATCTGGAACTGGAAAATCGAAGTACAGGCCCGCAAAGCATATGGACCTT
ACAAAGAAGACAAGGCTGAGGAGGCTTCCGCATGA

Upstream 100 bases:

>100_bases
CATATTTCTTTGTAATGATATGGCAGACGCTTTTAAAAAAATGTACAGCGTTTTTTGGAATCCAGTTTATTACATGTAAT
AACATAAAGGAGGAAAATGA

Downstream 100 bases:

>100_bases
TTGACGCTATCTTAGGAAATATCCTCTGGATGGTCTTCATTATTATCGGCGGCGTTCTGATTTCCTGGGGTGTTCACTTC
GTGCCCGTAGGTGGAGCACC

Product: tetrahydromethanopterin S-methyltransferase subunit E

Products: NA

Alternate protein names: N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MEPLIGMGVLALIGVAATIAGASEDLESDIGSQSNPNSQVQLAPQMMFPHRIFNKAISGEPPSNALMCSIGAAIATVLIS
EFTVSPLFALVFGSVIAASVHATFAVTATMGRCASQSRFKQPIYLDMIRSHTPAIMGYAFITTFCVLIVSYLMTVVLGHP
FPLTMLAFIWGITIGAIGSSTGDVHYGAEREFQQFEFGSGLNASNSGNIVRYAESGLRNGFDNSWFCSKFGGPTTGIAFG
MTVFLGSWITTIFDPAQGLSMGWLSVIAGVIIVLILIIWNWKIEVQARKAYGPYKEDKAEEASA

Sequences:

>Translated_304_residues
MEPLIGMGVLALIGVAATIAGASEDLESDIGSQSNPNSQVQLAPQMMFPHRIFNKAISGEPPSNALMCSIGAAIATVLIS
EFTVSPLFALVFGSVIAASVHATFAVTATMGRCASQSRFKQPIYLDMIRSHTPAIMGYAFITTFCVLIVSYLMTVVLGHP
FPLTMLAFIWGITIGAIGSSTGDVHYGAEREFQQFEFGSGLNASNSGNIVRYAESGLRNGFDNSWFCSKFGGPTTGIAFG
MTVFLGSWITTIFDPAQGLSMGWLSVIAGVIIVLILIIWNWKIEVQARKAYGPYKEDKAEEASA
>Mature_304_residues
MEPLIGMGVLALIGVAATIAGASEDLESDIGSQSNPNSQVQLAPQMMFPHRIFNKAISGEPPSNALMCSIGAAIATVLIS
EFTVSPLFALVFGSVIAASVHATFAVTATMGRCASQSRFKQPIYLDMIRSHTPAIMGYAFITTFCVLIVSYLMTVVLGHP
FPLTMLAFIWGITIGAIGSSTGDVHYGAEREFQQFEFGSGLNASNSGNIVRYAESGLRNGFDNSWFCSKFGGPTTGIAFG
MTVFLGSWITTIFDPAQGLSMGWLSVIAGVIIVLILIIWNWKIEVQARKAYGPYKEDKAEEASA

Specific function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step

COG id: COG4059

COG function: function code H; Tetrahydromethanopterin S-methyltransferase, subunit E

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mtrE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRE_METMA (P80651)

Other databases:

- EMBL:   AF042381
- EMBL:   AE008384
- RefSeq:   NP_633571.1
- GeneID:   1479889
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1547
- NMPDR:   fig|192952.1.peg.1547
- HOGENOM:   HBG539646
- OMA:   SNPNSQV
- ProtClustDB:   PRK00972
- BioCyc:   MMAZ192952:MM1547-MONOMER
- BRENDA:   2.1.1.86
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01098
- InterPro:   IPR005780
- PIRSF:   PIRSF016509
- TIGRFAMs:   TIGR01113

Pfam domain/function: PF04206 MtrE

EC number: =2.1.1.86

Molecular weight: Translated: 32489; Mature: 32489

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xedfe904)-; HASH(0xef866bc)-; HASH(0xec28418)-; HASH(0xee9d08c)-; HASH(0xdcb6a54)-; HASH(0xe4fef84)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLIGMGVLALIGVAATIAGASEDLESDIGSQSNPNSQVQLAPQMMFPHRIFNKAISGE
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHCCC
PPSNALMCSIGAAIATVLISEFTVSPLFALVFGSVIAASVHATFAVTATMGRCASQSRFK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPIYLDMIRSHTPAIMGYAFITTFCVLIVSYLMTVVLGHPFPLTMLAFIWGITIGAIGSS
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
TGDVHYGAEREFQQFEFGSGLNASNSGNIVRYAESGLRNGFDNSWFCSKFGGPTTGIAFG
CCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCCCCCCCEEHHCCCCCHHHHHHH
MTVFLGSWITTIFDPAQGLSMGWLSVIAGVIIVLILIIWNWKIEVQARKAYGPYKEDKAE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHH
EASA
CCCH
>Mature Secondary Structure
MEPLIGMGVLALIGVAATIAGASEDLESDIGSQSNPNSQVQLAPQMMFPHRIFNKAISGE
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHCCC
PPSNALMCSIGAAIATVLISEFTVSPLFALVFGSVIAASVHATFAVTATMGRCASQSRFK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPIYLDMIRSHTPAIMGYAFITTFCVLIVSYLMTVVLGHPFPLTMLAFIWGITIGAIGSS
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
TGDVHYGAEREFQQFEFGSGLNASNSGNIVRYAESGLRNGFDNSWFCSKFGGPTTGIAFG
CCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCCCCCCCEEHHCCCCCHHHHHHH
MTVFLGSWITTIFDPAQGLSMGWLSVIAGVIIVLILIIWNWKIEVQARKAYGPYKEDKAE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHH
EASA
CCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9559648; 12125824; 8774736