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The map label for this gene is mtrD

Identifier: 21227648

GI number: 21227648

Start: 1843319

End: 1844071

Strand: Reverse

Name: mtrD

Synonym: MM_1546

Alternate gene names: 21227648

Gene position: 1844071-1843319 (Counterclockwise)

Preceding gene: 21227649

Following gene: 21227647

Centisome position: 45.02

GC content: 48.07

Gene sequence:

>753_bases
ATGATTGACGCTATCTTAGGAAATATCCTCTGGATGGTCTTCATTATTATCGGCGGCGTTCTGATTTCCTGGGGTGTTCA
CTTCGTGCCCGTAGGTGGAGCACCTGCAGCTATGGCTCAGGCAACAGGTGTCGGTACCGGTACAGTGCAGCTGGCAACAG
GCGCAGGTCTGACAGGGCTTGTCAGTGCCGGATTTATGATGAACGTGACAGACAATTTCCCTCTTATTGTTGCCTCAGGC
GCAGTGGGAGCAATGATCATGATCGCTGTGACCATGATCGTAGGTACCTGGATCTATGTTTACGGTGTAGGCTGTGTGCC
TTCTTCCGCAAAAGTAAAGGTTGACCCAATAACAAAATACAGACAGGACCTTTACGTATCCCAGGGTACTGAAGGGCACG
GAATTCCGACTGTCAGCTTTGTGAGCGGAGTTATCGGTGCTGCTCTTGGTGGAATTGGTGGATCTCTTATTTACTATTCA
CTTATTGAAGTGGGTGTAAGTGTAGGACTTGAGCGCGTTGGAGTTACTTCTGCAGTAACAGGAAACTCGCTTGTAGCAGT
TGCAGCAATATTTGCAATAGGCATTTTCCTGGTAAACGCCGTAATTCCGTCCTATAACATAGGAGGTACAATTGAAGGGT
TCCACGACCCGAAATTCAAGAAATGGCCGAAGGCGGTTATTTCCTCCGTCGTGGCATCAATACTGTGTGCTATCGTGGCA
GTAATTGCAATAGCACAGCTAGGAGGTATCTAA

Upstream 100 bases:

>100_bases
TTATCGTCCTTATTTTAATTATCTGGAACTGGAAAATCGAAGTACAGGCCCGCAAAGCATATGGACCTTACAAAGAAGAC
AAGGCTGAGGAGGCTTCCGC

Downstream 100 bases:

>100_bases
AATGTCTGCAGGTGGAGCAGGAGGAGAAGCTAAAGGTGCATACCCTCAACAGACACTAATGGCCCTGGGTATAGTCGGCG
GTCTTGTCGGAATTTACCTT

Product: tetrahydromethanopterin S-methyltransferase subunit D

Products: NA

Alternate protein names: N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit D

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIDAILGNILWMVFIIIGGVLISWGVHFVPVGGAPAAMAQATGVGTGTVQLATGAGLTGLVSAGFMMNVTDNFPLIVASG
AVGAMIMIAVTMIVGTWIYVYGVGCVPSSAKVKVDPITKYRQDLYVSQGTEGHGIPTVSFVSGVIGAALGGIGGSLIYYS
LIEVGVSVGLERVGVTSAVTGNSLVAVAAIFAIGIFLVNAVIPSYNIGGTIEGFHDPKFKKWPKAVISSVVASILCAIVA
VIAIAQLGGI

Sequences:

>Translated_250_residues
MIDAILGNILWMVFIIIGGVLISWGVHFVPVGGAPAAMAQATGVGTGTVQLATGAGLTGLVSAGFMMNVTDNFPLIVASG
AVGAMIMIAVTMIVGTWIYVYGVGCVPSSAKVKVDPITKYRQDLYVSQGTEGHGIPTVSFVSGVIGAALGGIGGSLIYYS
LIEVGVSVGLERVGVTSAVTGNSLVAVAAIFAIGIFLVNAVIPSYNIGGTIEGFHDPKFKKWPKAVISSVVASILCAIVA
VIAIAQLGGI
>Mature_250_residues
MIDAILGNILWMVFIIIGGVLISWGVHFVPVGGAPAAMAQATGVGTGTVQLATGAGLTGLVSAGFMMNVTDNFPLIVASG
AVGAMIMIAVTMIVGTWIYVYGVGCVPSSAKVKVDPITKYRQDLYVSQGTEGHGIPTVSFVSGVIGAALGGIGGSLIYYS
LIEVGVSVGLERVGVTSAVTGNSLVAVAAIFAIGIFLVNAVIPSYNIGGTIEGFHDPKFKKWPKAVISSVVASILCAIVA
VIAIAQLGGI

Specific function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step

COG id: COG4060

COG function: function code H; Tetrahydromethanopterin S-methyltransferase, subunit D

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mtrD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRD_METMA (P80653)

Other databases:

- EMBL:   AF042381
- EMBL:   AE008384
- RefSeq:   NP_633570.1
- GeneID:   1479888
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1546
- NMPDR:   fig|192952.1.peg.1546
- HOGENOM:   HBG551221
- OMA:   HFVPVGG
- ProtClustDB:   PRK00968
- BioCyc:   MMAZ192952:MM1546-MONOMER
- BRENDA:   2.1.1.86
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01097
- InterPro:   IPR005779
- PIRSF:   PIRSF016552
- ProDom:   PD013594
- TIGRFAMs:   TIGR01112

Pfam domain/function: PF04207 MtrD

EC number: =2.1.1.86

Molecular weight: Translated: 25268; Mature: 25268

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe6fdf60)-; HASH(0xc7c00c8)-; HASH(0xeedfed4)-; HASH(0xe6087c8)-; HASH(0xdb8a2d4)-; HASH(0xb1ba2a4)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAILGNILWMVFIIIGGVLISWGVHFVPVGGAPAAMAQATGVGTGTVQLATGAGLTGL
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHH
VSAGFMMNVTDNFPLIVASGAVGAMIMIAVTMIVGTWIYVYGVGCVPSSAKVKVDPITKY
HHCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHH
RQDLYVSQGTEGHGIPTVSFVSGVIGAALGGIGGSLIYYSLIEVGVSVGLERVGVTSAVT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHCCC
GNSLVAVAAIFAIGIFLVNAVIPSYNIGGTIEGFHDPKFKKWPKAVISSVVASILCAIVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VIAIAQLGGI
HHHHHHHCCH
>Mature Secondary Structure
MIDAILGNILWMVFIIIGGVLISWGVHFVPVGGAPAAMAQATGVGTGTVQLATGAGLTGL
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHH
VSAGFMMNVTDNFPLIVASGAVGAMIMIAVTMIVGTWIYVYGVGCVPSSAKVKVDPITKY
HHCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHH
RQDLYVSQGTEGHGIPTVSFVSGVIGAALGGIGGSLIYYSLIEVGVSVGLERVGVTSAVT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHCCC
GNSLVAVAAIFAIGIFLVNAVIPSYNIGGTIEGFHDPKFKKWPKAVISSVVASILCAIVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VIAIAQLGGI
HHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9559648; 12125824; 8774736