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The map label for this gene is tetA [H]

Identifier: 21227567

GI number: 21227567

Start: 1748079

End: 1749413

Strand: Reverse

Name: tetA [H]

Synonym: MM_1465

Alternate gene names: 21227567

Gene position: 1749413-1748079 (Counterclockwise)

Preceding gene: 21227570

Following gene: 21227566

Centisome position: 42.71

GC content: 43.52

Gene sequence:

>1335_bases
TTGATAGACAGGAATGAAGGCAGTCTTTACCCTCAAACAGAAAAAAATATTCCCCTTTTACCTCTTCTTGCTGTTAACTT
CATAGGAACGCTGGGGTTTAGCATTGTGCTCCCATTCCTTGTGTTTCTGGTAGACAGGTTTGGGGGTAATGCCTTTGTTT
ACGGGCTGGTAAGTGCTATGTATCCCATATTCCAGTTCATAGGTGCTCCTGCTCTGGGCAGATGGTCTGACATTTACGGG
CGCAAGAAGGTTCTTCTCTTATGCCAGGTAGGAACCGTCATATCATGGATTGTCTTTCTCGGAGCTCTTTTTCTTCCGAT
TGTAACCCTTTTTAAAGTTGACTCTGAAATACTCGGGGATTTCGTATTTACTGTACCTCTTGCAATGCTTTTTGCTGCCA
GAGCCCTTGACGGACTTACCGGAGGCGACATATCCGTAGCCAACGCTTATCTCGCAGATATTACTCCAGAGAGGGATAGA
AATCGGAACTTCGGAAAAATGGCGATTTCTTCAAATCTAGGATTTATAGTCGGCCCTCTCCTTGCCGGAATTCTTAGCAT
GACAGAGTACGGAGATATAGCCCCTATCCTTGGAGCAATAATAATCTCAATTGCTGGAACGCTACTCATTATCCTCTATC
TCCCTGAAAGCAAAGAATGCTATCTTGCAGAACCTGAAGAAGCTGAAAATATAAGGAAAATAAGGAAAATTTTTGGCTAT
GAGATAAGGGAATGCAAAACTACAGGAGAGACAGAGAAACCTGACTTCAGGGAGGTTCTGAAACTTTCGAATATACCTTA
TATGCTTGGCCTTTATTTTCTAATAGATCTGGGTTATAACGTATTCTACACTGCTTTTCCTCTGCATGCAGTCGCATCTC
TTAACTGGAGCATTACAGAAATGGGCTTCTATTTTACGGCTTTGAGCGGGCTCATAATAATTGTACAGGGAACTTTGCTT
CCCAGGGCTTCGAGAAAGTATTCGGATGCTACCCTCATAATCTTTGGAAGCCTGATGCTTGGCACAAATTTCTTACTAAT
GATTCCTGGAAAACTCCCTCTGCTCTACTTTGCGACAGGATTTTTCGCGCTTGGAGACGGACTTATGTGGCCCTCTTTTC
TCTCCCTTTTATCAAAAGTTGCAGGAGCAAAATACCAGGGCACTGTACAGGGGTTTGGCAGCAGTTTCTCCGGACTTGCC
AGCATTACAGGGCTGATCCTTGGAGGTCTCTTATATGAACTGCTGGCAGGAAAAGCCTTTTTGCTTGCAGGCATGGCTAT
TTACACCGTATTTTTGCTTAATTTCAGGCTCAGGCATTTTGAGAAAGAACTGTAA

Upstream 100 bases:

>100_bases
TTATTTGAGGGGATGAATAATACTGCTTGTGGAAGCAGGGGGAAAAGAGAGGATTCCTGAAGACAGGCAGGAAAAGATAT
CAGTGGATAAAGCTGAAGAT

Downstream 100 bases:

>100_bases
CAGTGAATTGAATTTAAACCCTATTCTGCTTAAGTTTTCAAGAAATAAGTTAAATGAAAGAAAGCAGAAACAAAAATGTT
TAAGTAAATTGAGCTGTATA

Product: hypothetical protein

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIDRNEGSLYPQTEKNIPLLPLLAVNFIGTLGFSIVLPFLVFLVDRFGGNAFVYGLVSAMYPIFQFIGAPALGRWSDIYG
RKKVLLLCQVGTVISWIVFLGALFLPIVTLFKVDSEILGDFVFTVPLAMLFAARALDGLTGGDISVANAYLADITPERDR
NRNFGKMAISSNLGFIVGPLLAGILSMTEYGDIAPILGAIIISIAGTLLIILYLPESKECYLAEPEEAENIRKIRKIFGY
EIRECKTTGETEKPDFREVLKLSNIPYMLGLYFLIDLGYNVFYTAFPLHAVASLNWSITEMGFYFTALSGLIIIVQGTLL
PRASRKYSDATLIIFGSLMLGTNFLLMIPGKLPLLYFATGFFALGDGLMWPSFLSLLSKVAGAKYQGTVQGFGSSFSGLA
SITGLILGGLLYELLAGKAFLLAGMAIYTVFLLNFRLRHFEKEL

Sequences:

>Translated_444_residues
MIDRNEGSLYPQTEKNIPLLPLLAVNFIGTLGFSIVLPFLVFLVDRFGGNAFVYGLVSAMYPIFQFIGAPALGRWSDIYG
RKKVLLLCQVGTVISWIVFLGALFLPIVTLFKVDSEILGDFVFTVPLAMLFAARALDGLTGGDISVANAYLADITPERDR
NRNFGKMAISSNLGFIVGPLLAGILSMTEYGDIAPILGAIIISIAGTLLIILYLPESKECYLAEPEEAENIRKIRKIFGY
EIRECKTTGETEKPDFREVLKLSNIPYMLGLYFLIDLGYNVFYTAFPLHAVASLNWSITEMGFYFTALSGLIIIVQGTLL
PRASRKYSDATLIIFGSLMLGTNFLLMIPGKLPLLYFATGFFALGDGLMWPSFLSLLSKVAGAKYQGTVQGFGSSFSGLA
SITGLILGGLLYELLAGKAFLLAGMAIYTVFLLNFRLRHFEKEL
>Mature_444_residues
MIDRNEGSLYPQTEKNIPLLPLLAVNFIGTLGFSIVLPFLVFLVDRFGGNAFVYGLVSAMYPIFQFIGAPALGRWSDIYG
RKKVLLLCQVGTVISWIVFLGALFLPIVTLFKVDSEILGDFVFTVPLAMLFAARALDGLTGGDISVANAYLADITPERDR
NRNFGKMAISSNLGFIVGPLLAGILSMTEYGDIAPILGAIIISIAGTLLIILYLPESKECYLAEPEEAENIRKIRKIFGY
EIRECKTTGETEKPDFREVLKLSNIPYMLGLYFLIDLGYNVFYTAFPLHAVASLNWSITEMGFYFTALSGLIIIVQGTLL
PRASRKYSDATLIIFGSLMLGTNFLLMIPGKLPLLYFATGFFALGDGLMWPSFLSLLSKVAGAKYQGTVQGFGSSFSGLA
SITGLILGGLLYELLAGKAFLLAGMAIYTVFLLNFRLRHFEKEL

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=444, Percent_Identity=24.5495495495495, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI225703104, Length=163, Percent_Identity=26.3803680981595, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI225703102, Length=163, Percent_Identity=26.3803680981595, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17551570, Length=386, Percent_Identity=25.9067357512953, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71996331, Length=392, Percent_Identity=23.7244897959184, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17738085, Length=382, Percent_Identity=20.6806282722513, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221513297, Length=208, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48719; Mature: 48719

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRNEGSLYPQTEKNIPLLPLLAVNFIGTLGFSIVLPFLVFLVDRFGGNAFVYGLVSAM
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YPIFQFIGAPALGRWSDIYGRKKVLLLCQVGTVISWIVFLGALFLPIVTLFKVDSEILGD
HHHHHHHCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFTVPLAMLFAARALDGLTGGDISVANAYLADITPERDRNRNFGKMAISSNLGFIVGPL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHHHH
LAGILSMTEYGDIAPILGAIIISIAGTLLIILYLPESKECYLAEPEEAENIRKIRKIFGY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCEECCCHHHHHHHHHHHHHCC
EIRECKTTGETEKPDFREVLKLSNIPYMLGLYFLIDLGYNVFYTAFPLHAVASLNWSITE
HHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHH
MGFYFTALSGLIIIVQGTLLPRASRKYSDATLIIFGSLMLGTNFLLMIPGKLPLLYFATG
HHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEEHHHHHCCCEEEEECCCCHHHHHHHH
FFALGDGLMWPSFLSLLSKVAGAKYQGTVQGFGSSFSGLASITGLILGGLLYELLAGKAF
HHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHH
LLAGMAIYTVFLLNFRLRHFEKEL
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDRNEGSLYPQTEKNIPLLPLLAVNFIGTLGFSIVLPFLVFLVDRFGGNAFVYGLVSAM
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YPIFQFIGAPALGRWSDIYGRKKVLLLCQVGTVISWIVFLGALFLPIVTLFKVDSEILGD
HHHHHHHCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFTVPLAMLFAARALDGLTGGDISVANAYLADITPERDRNRNFGKMAISSNLGFIVGPL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHHHH
LAGILSMTEYGDIAPILGAIIISIAGTLLIILYLPESKECYLAEPEEAENIRKIRKIFGY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCEECCCHHHHHHHHHHHHHCC
EIRECKTTGETEKPDFREVLKLSNIPYMLGLYFLIDLGYNVFYTAFPLHAVASLNWSITE
HHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHH
MGFYFTALSGLIIIVQGTLLPRASRKYSDATLIIFGSLMLGTNFLLMIPGKLPLLYFATG
HHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEEHHHHHCCCEEEEECCCCHHHHHHHH
FFALGDGLMWPSFLSLLSKVAGAKYQGTVQGFGSSFSGLASITGLILGGLLYELLAGKAF
HHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHH
LLAGMAIYTVFLLNFRLRHFEKEL
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]