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The map label for this gene is 21227473

Identifier: 21227473

GI number: 21227473

Start: 1641948

End: 1642976

Strand: Direct

Name: 21227473

Synonym: MM_1371

Alternate gene names: NA

Gene position: 1641948-1642976 (Clockwise)

Preceding gene: 21227471

Following gene: 21227474

Centisome position: 40.08

GC content: 48.4

Gene sequence:

>1029_bases
GTGATTTTAATGAGGACAATCGACTGGAATGAAGAGTCCAATTCTGTGGTTCTGGTAGACCAGACCTTACTCCCGCAAGA
ATATAAAGTAATAGAATGCAAAACCCTGAGTTCTTTATGTGAGGCTATACAGTCTCTCAGGATCAGGGGCGCACCAGCGC
TGGGTGCTGCAGGAGGTTTCGGAATTGCCCTGGCAGCTTACCTGAGTGGGGCAAAAGATATCGAATCCATGACAAAAGAC
CTTAAGGTTGCGGCAAAAGCCCTTAAATCCACTCGCCCTACAGCCGTGAACCTGGCATGGGGTGTGGACAGAGTTTTAAA
TGCAATTTCTGATGCATTTGATTTCCGGGGCATACGCGATATTGCTCTTCAGGAAGCCAGGGATATTGCAGAAGAAGATA
TCGAAACAAATAAGCTGATAGGTAAATACGGAGCAAAACTTCTGAAAGACGGGGATACCGTACTTACACACTGCAATGCT
GGGAGGCTTGCCTGCGTTGATTGGGGCACAGCCCTCGGAGTGGTGCGTTCGGCTATTGCTGACGGTAAAGAGATTAAAGT
CCTTGCCTGTGAAACAAGACCTCTGAACCAGGGAAGCAGGATCACTACCTGGGAGCTCATGCAGGACAAAATCCCCGTAA
CCCTTATTGCGGATTCCATGGCTGGCTGGGCAATGCGCCAGGGGCTTGTAAACAGTGTGCTTGTTGGGGCTGACCGGATA
ACCCAGGATGTTGTGTTTAACAAGATAGGCACTTACACGCATTCTATCCTTGCGAGAGAACATGAAATCCCCTTTTATGT
GGCAGCTCCTGTCTCTACTTTTGATTTTGAAGGCTGGGAAGGGAGCATAAAGATCGAAATGCGAAATCCTGACGAACTGC
GGTTTGCAGGTTGCCAGCAGCTTGCCCCTGAAGACGTTCCTGTTTATAACCCTGCTTTTGATGCAACCCCCATGGAAAAT
GTAACCGCATTGATCACAGAAAGAGGTGTATTTTATCCGCCTATCCTGCTGGATGAGGTTCTCGTCTGA

Upstream 100 bases:

>100_bases
TCTCGCCTGAAAAAGGACGCCGAATAAGTTTTTATCTGATGGGTGGCTTGAAAAGAAAGTCGGTAAATTCTCCGGCAGAA
GCTGGTGTTTACATCGGAAA

Downstream 100 bases:

>100_bases
GAGTCCTCAGGTCTCTGTTTCTGGTATCTGATTTTGATATCCTGAAATCGGAGGCTTGCTTTTATAATATACAGAACTAT
CCCGGAAACGGGCACGATCT

Product: translation initiation factor IF-2B subunit alpha

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MILMRTIDWNEESNSVVLVDQTLLPQEYKVIECKTLSSLCEAIQSLRIRGAPALGAAGGFGIALAAYLSGAKDIESMTKD
LKVAAKALKSTRPTAVNLAWGVDRVLNAISDAFDFRGIRDIALQEARDIAEEDIETNKLIGKYGAKLLKDGDTVLTHCNA
GRLACVDWGTALGVVRSAIADGKEIKVLACETRPLNQGSRITTWELMQDKIPVTLIADSMAGWAMRQGLVNSVLVGADRI
TQDVVFNKIGTYTHSILAREHEIPFYVAAPVSTFDFEGWEGSIKIEMRNPDELRFAGCQQLAPEDVPVYNPAFDATPMEN
VTALITERGVFYPPILLDEVLV

Sequences:

>Translated_342_residues
MILMRTIDWNEESNSVVLVDQTLLPQEYKVIECKTLSSLCEAIQSLRIRGAPALGAAGGFGIALAAYLSGAKDIESMTKD
LKVAAKALKSTRPTAVNLAWGVDRVLNAISDAFDFRGIRDIALQEARDIAEEDIETNKLIGKYGAKLLKDGDTVLTHCNA
GRLACVDWGTALGVVRSAIADGKEIKVLACETRPLNQGSRITTWELMQDKIPVTLIADSMAGWAMRQGLVNSVLVGADRI
TQDVVFNKIGTYTHSILAREHEIPFYVAAPVSTFDFEGWEGSIKIEMRNPDELRFAGCQQLAPEDVPVYNPAFDATPMEN
VTALITERGVFYPPILLDEVLV
>Mature_342_residues
MILMRTIDWNEESNSVVLVDQTLLPQEYKVIECKTLSSLCEAIQSLRIRGAPALGAAGGFGIALAAYLSGAKDIESMTKD
LKVAAKALKSTRPTAVNLAWGVDRVLNAISDAFDFRGIRDIALQEARDIAEEDIETNKLIGKYGAKLLKDGDTVLTHCNA
GRLACVDWGTALGVVRSAIADGKEIKVLACETRPLNQGSRITTWELMQDKIPVTLIADSMAGWAMRQGLVNSVLVGADRI
TQDVVFNKIGTYTHSILAREHEIPFYVAAPVSTFDFEGWEGSIKIEMRNPDELRFAGCQQLAPEDVPVYNPAFDATPMEN
VTALITERGVFYPPILLDEVLV

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=338, Percent_Identity=37.5739644970414, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI23943880, Length=326, Percent_Identity=33.4355828220859, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI4503503, Length=203, Percent_Identity=28.0788177339901, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=334, Percent_Identity=35.3293413173653, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17557123, Length=237, Percent_Identity=25.3164556962025, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325375, Length=384, Percent_Identity=33.0729166666667, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322878, Length=275, Percent_Identity=25.0909090909091, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357667, Length=351, Percent_Identity=35.042735042735, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651647, Length=351, Percent_Identity=35.042735042735, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21358605, Length=225, Percent_Identity=27.5555555555556, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 37371; Mature: 37371

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMRTIDWNEESNSVVLVDQTLLPQEYKVIECKTLSSLCEAIQSLRIRGAPALGAAGGF
CEEEEEECCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCH
GIALAAYLSGAKDIESMTKDLKVAAKALKSTRPTAVNLAWGVDRVLNAISDAFDFRGIRD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHH
IALQEARDIAEEDIETNKLIGKYGAKLLKDGDTVLTHCNAGRLACVDWGTALGVVRSAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHC
DGKEIKVLACETRPLNQGSRITTWELMQDKIPVTLIADSMAGWAMRQGLVNSVLVGADRI
CCCEEEEEEECCCCCCCCCCEEHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
TQDVVFNKIGTYTHSILAREHEIPFYVAAPVSTFDFEGWEGSIKIEMRNPDELRFAGCQQ
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCCEEEEEECCCCHHHHHHHHH
LAPEDVPVYNPAFDATPMENVTALITERGVFYPPILLDEVLV
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MILMRTIDWNEESNSVVLVDQTLLPQEYKVIECKTLSSLCEAIQSLRIRGAPALGAAGGF
CEEEEEECCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCH
GIALAAYLSGAKDIESMTKDLKVAAKALKSTRPTAVNLAWGVDRVLNAISDAFDFRGIRD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHH
IALQEARDIAEEDIETNKLIGKYGAKLLKDGDTVLTHCNAGRLACVDWGTALGVVRSAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHC
DGKEIKVLACETRPLNQGSRITTWELMQDKIPVTLIADSMAGWAMRQGLVNSVLVGADRI
CCCEEEEEEECCCCCCCCCCEEHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
TQDVVFNKIGTYTHSILAREHEIPFYVAAPVSTFDFEGWEGSIKIEMRNPDELRFAGCQQ
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCCEEEEEECCCCHHHHHHHHH
LAPEDVPVYNPAFDATPMENVTALITERGVFYPPILLDEVLV
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]