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The map label for this gene is fae-hps [H]

Identifier: 21227381

GI number: 21227381

Start: 1514605

End: 1515783

Strand: Reverse

Name: fae-hps [H]

Synonym: MM_1279

Alternate gene names: 21227381

Gene position: 1515783-1514605 (Counterclockwise)

Preceding gene: 21227382

Following gene: 21227380

Centisome position: 37.0

GC content: 49.62

Gene sequence:

>1179_bases
ATGTTTCAGATAGGAGAAGCATTAATGGGGCAGGGCTCAGAACTTGCCCACGTTGATTTGATGATAGGAGACAAGGGAGG
TCCAGTAGGGCAGGCTTTTGCAAACGGCCTTACCCAGCTTTCAGCCGGGCACACCCCTCTCCTTTCAGTTATCAGGCCAA
ATCTGCCGCCCAAGCCTTCAACCCTTATTATCCCGAAGGTCACTGTAAAAAACATGGACCAGGCAGCTAGGATTTTCGGA
CCTGCCCAGTCAGCTGTTGCAAAAGCAGTAGCAGACTCCGTGGAAGAAGGCGTGATCCCGAAGGACCAGGTTGAAGACCT
TGTTATTGTGGCAAGCGTTTTTATCCACCCTGAAGCCCAGGACTACAATAAAATCTACAGGTACAACTACGGAGCCACAA
AACTCGCAATAAAGAGGGCACTTGAAGGCTTCCCTGACATCGACACTGTACTTGAGGAAAGCAACAAGTCCACACATGCT
ATCATGGGATTCAAAGTTACAAGGCTCTGGGACCCACCATATCTGCAGATTGCCTTTGACAACCCGAACCTTGAGTTCGT
GCTCTCGGCTATCTCGGAAATCCCGAAGAGCGACCACGTAATCATCGAAGCAGGCACGCCACTTATCAAGCGCTACGGCA
CAGATGTTATTTCCAAGATCAGGCAGGTAAGACCGGATGCATTCATCGTTGCTGACTTGAAGACTCTGGACACCGGAAAC
CTTGAAGCCAGAATGGTTGCAGACGCCGCAGGTGACGCTATTGTAGTTTCAGCCCTTGCTCCTATCAGCACCATTGATAA
ACTTATTGAGGAAGCCCACAAGACCGGAATCTACGCGGTTATGGACACCCTTAATCAGCAGGATCCGATTTCTGTCTTAA
AGCAGCTCAAAGTCATGCCAGATGTCATTGAGCTTCACCGTGGAATCGATATTGAAGGCACAGAACACGCCTGGGGCAAT
ATTGGAGAAATCAAAAAGATCGCTCCAAAGGCTCTGGTTGCAGTTGCAGGTGGAGTCCGCCTCGACAAGGTTCCTGTAGC
CCTCAGCCAGGGTGCTGATATCCTTGTGGTCGGACGTGCAATCACCAATGCAAAAGACGTCAGGGAAATGGCTGAACAGT
TTATCAACAGCCTTAATAAGCCAGAGATTGACCAGTTCAGAGTCATGACAGACTTCTGA

Upstream 100 bases:

>100_bases
AAACATCATTCTTTACATTGTACTCTCAAAATTCAATACTCTGCACAGTGTATATCATCAGTAATCTGCATCTCACATTT
ACCATTTCGCGAGGTTAAAC

Downstream 100 bases:

>100_bases
AAGCGTGTATTTTCACGCTTTTTCTTTTCTTTTTTCAGGAGGGGATTTTTTTGGGTTCACCATTCATTTTACTGAACTAT
AAGACTTATATACAGGGCAC

Product: bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase

Products: NA

Alternate protein names: Formaldehyde-activating enzyme; Fae; 3-hexulose-6-phosphate synthase; HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPSTLIIPKVTVKNMDQAARIFG
PAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQDYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHA
IMGFKVTRLWDPPYLQIAFDNPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRGIDIEGTEHAWGN
IGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVREMAEQFINSLNKPEIDQFRVMTDF

Sequences:

>Translated_392_residues
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPSTLIIPKVTVKNMDQAARIFG
PAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQDYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHA
IMGFKVTRLWDPPYLQIAFDNPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRGIDIEGTEHAWGN
IGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
>Mature_392_residues
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPSTLIIPKVTVKNMDQAARIFG
PAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQDYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHA
IMGFKVTRLWDPPYLQIAFDNPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMPDVIELHRGIDIEGTEHAWGN
IGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVREMAEQFINSLNKPEIDQFRVMTDF

Specific function: Catalyzes the formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790006, Length=205, Percent_Identity=24.390243902439, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790640, Length=213, Percent_Identity=26.2910798122066, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR020868
- InterPro:   IPR014826
- InterPro:   IPR001754
- InterPro:   IPR020568
- InterPro:   IPR011060 [H]

Pfam domain/function: PF08714 Fae; PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 42447; Mature: 42447

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
CCCCCCHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
EEEECCHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEHHHHCCCCCC
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
CCCHHEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEEEC
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
CCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHCHHHHHHHHHCCCCEEEEEEEEECCCCC
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
CCEEEEECCCCCEEEEHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCH
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHCCCCCEEEECCH
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
HCCHHHHHHHHHHHHHHCCCCCCHHEEEEECC
>Mature Secondary Structure
MFQIGEALMGQGSELAHVDLMIGDKGGPVGQAFANGLTQLSAGHTPLLSVIRPNLPPKPS
CCCCCCHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
TLIIPKVTVKNMDQAARIFGPAQSAVAKAVADSVEEGVIPKDQVEDLVIVASVFIHPEAQ
EEEECCHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEHHHHCCCCCC
DYNKIYRYNYGATKLAIKRALEGFPDIDTVLEESNKSTHAIMGFKVTRLWDPPYLQIAFD
CCCHHEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEEEC
NPNLEFVLSAISEIPKSDHVIIEAGTPLIKRYGTDVISKIRQVRPDAFIVADLKTLDTGN
CCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHCHHHHHHHHHCCCCEEEEEEEEECCCCC
LEARMVADAAGDAIVVSALAPISTIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQLKVMP
CCEEEEECCCCCEEEEHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCH
DVIELHRGIDIEGTEHAWGNIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRA
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHCCCCCEEEECCH
ITNAKDVREMAEQFINSLNKPEIDQFRVMTDF
HCCHHHHHHHHHHHHHHCCCCCCHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]