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The map label for this gene is htpX1

Identifier: 21227338

GI number: 21227338

Start: 1463250

End: 1464113

Strand: Direct

Name: htpX1

Synonym: MM_1236

Alternate gene names: 21227338

Gene position: 1463250-1464113 (Clockwise)

Preceding gene: 21227337

Following gene: 21227339

Centisome position: 35.72

GC content: 49.65

Gene sequence:

>864_bases
ATGAAGAACATGCTTAAAACTACAGTTTTGCTTGCCGCCCTTACAGGTCTCCTTGTTATCATAGGTGACTACTTTGGCGG
AACAGGCGGAATGATCATCGCATTCCTGTTTGCAGTAGTTCTCAACTTTGGGAGCTACTGGTACAGTGACAAGATAGTCC
TTAAGATGTACAGGGCAAAAGAAGTTTCCCCGGCGGAAGCTCCAAACCTGCACAGGATTGTCGATGGGCTCGTGATGAAA
GCAGGAATACCAAAACCTAAAGTGTATATTGTACAGTCCGGAATGCCCAATGCCTTTGCAACCGGCAGAGATCCAAAGCA
TGCGGCTGTGGCTGCAACTACCGGAATTCTTGAGCTCCTCTCTTATGAAGAGATGGAAGGTGTACTGGCACACGAGCTGG
CACACGTAAAGAACAGGGATACCCTGATAAGTGCTATAGCTGCAACCCTTGCAGGTGTTGTCACAATGCTTGCTCACTGG
GCGCAGTGGGCTGCAATATTCGGCGGTTTCGGAGGCAGAGACGATGACGGCAACGGCGGAATCGTTGGCCTTATTGCAAT
GGCCATTGTGGCGCCGATTGCTGCAACCCTTATCCAGCTTGCAATCTCAAGGTCAAGAGAATTTGCAGCCGATGAAGAAG
GAGCCAGGATTTCCAGAAAACCATGGGCTCTTGCTGATGCTCTTGAAAAGCTCGAATATGGGAACTCTCATTACAGAGCG
AGAGTCTCAGATGTACAGGCAAAGGAAAGCAGTGCCCACATGTTTATTGTCAACCCTCTGAAAGGAGGAGCTGTTCAGTC
CCTCTTCAGGACTCACCCCGTGACCGATGAACGTGTAAGGCGCCTGAGGGCAATGAAGTTCTAA

Upstream 100 bases:

>100_bases
TTGATTCTATTTAATCGAACTTATTAAAATAAGTCCAGAACATAGAAATCAAAGACCGAAAACCCAGACGTTAGCCTGGG
AGGACGTCGTGTGAGAAGTC

Downstream 100 bases:

>100_bases
AGCCCTCTAACTTTTTAAGTTTCATTTTTATTTCTACCTTTTGACCTATCTTCGATTTTGTTCTTCGATTCATTTTTAAT
TTGTTTTCAGTATTCATCTT

Product: protease HTPX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKNMLKTTVLLAALTGLLVIIGDYFGGTGGMIIAFLFAVVLNFGSYWYSDKIVLKMYRAKEVSPAEAPNLHRIVDGLVMK
AGIPKPKVYIVQSGMPNAFATGRDPKHAAVAATTGILELLSYEEMEGVLAHELAHVKNRDTLISAIAATLAGVVTMLAHW
AQWAAIFGGFGGRDDDGNGGIVGLIAMAIVAPIAATLIQLAISRSREFAADEEGARISRKPWALADALEKLEYGNSHYRA
RVSDVQAKESSAHMFIVNPLKGGAVQSLFRTHPVTDERVRRLRAMKF

Sequences:

>Translated_287_residues
MKNMLKTTVLLAALTGLLVIIGDYFGGTGGMIIAFLFAVVLNFGSYWYSDKIVLKMYRAKEVSPAEAPNLHRIVDGLVMK
AGIPKPKVYIVQSGMPNAFATGRDPKHAAVAATTGILELLSYEEMEGVLAHELAHVKNRDTLISAIAATLAGVVTMLAHW
AQWAAIFGGFGGRDDDGNGGIVGLIAMAIVAPIAATLIQLAISRSREFAADEEGARISRKPWALADALEKLEYGNSHYRA
RVSDVQAKESSAHMFIVNPLKGGAVQSLFRTHPVTDERVRRLRAMKF
>Mature_287_residues
MKNMLKTTVLLAALTGLLVIIGDYFGGTGGMIIAFLFAVVLNFGSYWYSDKIVLKMYRAKEVSPAEAPNLHRIVDGLVMK
AGIPKPKVYIVQSGMPNAFATGRDPKHAAVAATTGILELLSYEEMEGVLAHELAHVKNRDTLISAIAATLAGVVTMLAHW
AQWAAIFGGFGGRDDDGNGGIVGLIAMAIVAPIAATLIQLAISRSREFAADEEGARISRKPWALADALEKLEYGNSHYRA
RVSDVQAKESSAHMFIVNPLKGGAVQSLFRTHPVTDERVRRLRAMKF

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=272, Percent_Identity=30.5147058823529, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX1_METMA (Q8PXI2)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633260.1
- ProteinModelPortal:   Q8PXI2
- MEROPS:   M48.004
- GeneID:   1479578
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1236
- NMPDR:   fig|192952.1.peg.1236
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   CLSK450609
- BioCyc:   MMAZ192952:MM1236-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31006; Mature: 31006

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

HASH(0xd0e1b90)-; HASH(0xb9c02f0)-; HASH(0xe893ce0)-; HASH(0xe58c1bc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNMLKTTVLLAALTGLLVIIGDYFGGTGGMIIAFLFAVVLNFGSYWYSDKIVLKMYRAK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
EVSPAEAPNLHRIVDGLVMKAGIPKPKVYIVQSGMPNAFATGRDPKHAAVAATTGILELL
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
SYEEMEGVLAHELAHVKNRDTLISAIAATLAGVVTMLAHWAQWAAIFGGFGGRDDDGNGG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
IVGLIAMAIVAPIAATLIQLAISRSREFAADEEGARISRKPWALADALEKLEYGNSHYRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
RVSDVQAKESSAHMFIVNPLKGGAVQSLFRTHPVTDERVRRLRAMKF
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCH
>Mature Secondary Structure
MKNMLKTTVLLAALTGLLVIIGDYFGGTGGMIIAFLFAVVLNFGSYWYSDKIVLKMYRAK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
EVSPAEAPNLHRIVDGLVMKAGIPKPKVYIVQSGMPNAFATGRDPKHAAVAATTGILELL
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
SYEEMEGVLAHELAHVKNRDTLISAIAATLAGVVTMLAHWAQWAAIFGGFGGRDDDGNGG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
IVGLIAMAIVAPIAATLIQLAISRSREFAADEEGARISRKPWALADALEKLEYGNSHYRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
RVSDVQAKESSAHMFIVNPLKGGAVQSLFRTHPVTDERVRRLRAMKF
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12125824