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The map label for this gene is wecC [H]

Identifier: 21227256

GI number: 21227256

Start: 1371087

End: 1372523

Strand: Direct

Name: wecC [H]

Synonym: MM_1154

Alternate gene names: 21227256

Gene position: 1371087-1372523 (Clockwise)

Preceding gene: 21227255

Following gene: 21227257

Centisome position: 33.47

GC content: 47.6

Gene sequence:

>1437_bases
GTGATAAGTATGAGCAAATTAGAAAAACTTTTGAAGGAACGCGGCCCTATAAAAAAGATAGGCGTTCTTGGCATGGGATA
TGTAGGAATCCCTGCTGCTGTCCTTTTTGCAGATGCTCCCTGTTTTGAGAAAGTCCTCGGCTTCCAGCGCAACTCAAAAA
GCTCGGGTTATAAAATTGAAATGCTTAACAGAGGGGAGAGCCCGCTCAAAGGGGAAGAGCCCGGCCTTGAAGAGCTTATT
GGAAAGGTTGTAAAAGCCGGAAAGTTCGAATGCACACCTGATTTTTCAAGGATTTCCGAGCTTGATGCAGTTACACTTGC
AATTCAGACTCCTTTTGCAAATCCCAAAGACCTGGAACCTGATTTCAGCGCGCTTATAGATGGTATCAGAAATGTGGGCA
AATACCTTAAACCGGGGATGCTTGTGGTCCTGGAATCCACAATTACTCCCGGGACAACTGAAGGCATGGCAAAACAGATC
CTTGAAGAAGAGTCAGGGCTAAAAGCAGGTGAAGATTTTGCCCTTGCACACGCCCCCGAAAGAGTGATGGTAGGCAGGCT
TTTAAAGAACATCAGAGAACACGACAGGATCGTGGGCGGAATAGATGAAGCAAGCACAAAAAGGGCTGTTGAACTGTACT
CCCCTGTGCTCACAGTCGGACAGGTTATCCCTATGAGTGCAACAGCGGCTGAGGTCACAAAAACCGCAGAAAACACTTTT
CGCGACCTTCAGATTGCAGCAATCAACCAGCTCGCCCTTTACTGTGAAGCTATGGGCATAAATGTCTATGATGTCAGGAC
AGGAGTCGACAGCTTAAAAGGCGAGGGAATTACAAGGGCTGTCCTCTGGCCCGGAGCAGGAGTTGGAGGCCACTGCCTGA
CCAAAGACACTTACCACCTTGAAAGAGGAGTTAAAATCGGGAGGGGAGAACTTGACTATCCGGAAGGTGCAGATTCTATT
TACGTGCTTGCAAGGAAAGTCAATGATTTCATGCCCGCACACATGTATAACCTGACCGTTGCAGCCCTTGAAAGGCTCGG
GAAGAAGATGGATGGCTCAAAAGTCGCAATGCTCGGCTGGGCATTTATCAAAGATTCGGACGATGCCAGAAACACACCTT
CGGAACCATACAGGGACCTCTGCCTGAAAGCCGGGGCCAGCGTAATGGTACACGACCCTTACGTTGTCAATTATCCGGGC
GTTGAAATTTCAGATAATCTGGAAGAGGTTGTCAGAAACGCAGACGCTATAGTTGTACTTGCAGGGCACAGTGCATACTC
CAGCCTTAAAGCTGATTGGGCAAAGAAAGTAAGCGCAAAAGCAAATCCGGTTATTATTGATGGGAGAAATGTCATCGAGC
CGGACGAATTTATCGGGAAAGGGTTCGTTTACAAGGGAATTGGGAGGGGGGACAAAAACTCACATAAAATAAAATGA

Upstream 100 bases:

>100_bases
AAGTGGGGAAGTAAACCGCATAAAAGATAAAGGGTGAAGGGAAAAAGAAACCGAAAGCCTCGGGAAAATTCAAAAAAATT
TTAAAAAACAATACCGGAAA

Downstream 100 bases:

>100_bases
AGGGGAAAATTCCCCTTTGATATATTTTATATTCTGGGAAACAGGGCGAAAATTATGTTTGATAAACTGAAAGAAAACGA
AGAACTCTGGGACCTCTTTA

Product: NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MISMSKLEKLLKERGPIKKIGVLGMGYVGIPAAVLFADAPCFEKVLGFQRNSKSSGYKIEMLNRGESPLKGEEPGLEELI
GKVVKAGKFECTPDFSRISELDAVTLAIQTPFANPKDLEPDFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQI
LEEESGLKAGEDFALAHAPERVMVGRLLKNIREHDRIVGGIDEASTKRAVELYSPVLTVGQVIPMSATAAEVTKTAENTF
RDLQIAAINQLALYCEAMGINVYDVRTGVDSLKGEGITRAVLWPGAGVGGHCLTKDTYHLERGVKIGRGELDYPEGADSI
YVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGWAFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYPG
VEISDNLEEVVRNADAIVVLAGHSAYSSLKADWAKKVSAKANPVIIDGRNVIEPDEFIGKGFVYKGIGRGDKNSHKIK

Sequences:

>Translated_478_residues
MISMSKLEKLLKERGPIKKIGVLGMGYVGIPAAVLFADAPCFEKVLGFQRNSKSSGYKIEMLNRGESPLKGEEPGLEELI
GKVVKAGKFECTPDFSRISELDAVTLAIQTPFANPKDLEPDFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQI
LEEESGLKAGEDFALAHAPERVMVGRLLKNIREHDRIVGGIDEASTKRAVELYSPVLTVGQVIPMSATAAEVTKTAENTF
RDLQIAAINQLALYCEAMGINVYDVRTGVDSLKGEGITRAVLWPGAGVGGHCLTKDTYHLERGVKIGRGELDYPEGADSI
YVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGWAFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYPG
VEISDNLEEVVRNADAIVVLAGHSAYSSLKADWAKKVSAKANPVIIDGRNVIEPDEFIGKGFVYKGIGRGDKNSHKIK
>Mature_478_residues
MISMSKLEKLLKERGPIKKIGVLGMGYVGIPAAVLFADAPCFEKVLGFQRNSKSSGYKIEMLNRGESPLKGEEPGLEELI
GKVVKAGKFECTPDFSRISELDAVTLAIQTPFANPKDLEPDFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQI
LEEESGLKAGEDFALAHAPERVMVGRLLKNIREHDRIVGGIDEASTKRAVELYSPVLTVGQVIPMSATAAEVTKTAENTF
RDLQIAAINQLALYCEAMGINVYDVRTGVDSLKGEGITRAVLWPGAGVGGHCLTKDTYHLERGVKIGRGELDYPEGADSI
YVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGWAFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYPG
VEISDNLEEVVRNADAIVVLAGHSAYSSLKADWAKKVSAKANPVIIDGRNVIEPDEFIGKGFVYKGIGRGDKNSHKIK

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=483, Percent_Identity=25.2587991718427, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI296040438, Length=358, Percent_Identity=24.8603351955307, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI296040443, Length=318, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=31.6279069767442, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788340, Length=293, Percent_Identity=28.3276450511945, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=490, Percent_Identity=22.8571428571429, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136908, Length=481, Percent_Identity=24.948024948025, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 51826; Mature: 51826

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISMSKLEKLLKERGPIKKIGVLGMGYVGIPAAVLFADAPCFEKVLGFQRNSKSSGYKIE
CCCHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEE
MLNRGESPLKGEEPGLEELIGKVVKAGKFECTPDFSRISELDAVTLAIQTPFANPKDLEP
EECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCEEEEEEECCCCCCCCCCC
DFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQILEEESGLKAGEDFALAHAPE
CHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCH
RVMVGRLLKNIREHDRIVGGIDEASTKRAVELYSPVLTVGQVIPMSATAAEVTKTAENTF
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RDLQIAAINQLALYCEAMGINVYDVRTGVDSLKGEGITRAVLWPGAGVGGHCLTKDTYHL
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHH
ERGVKIGRGELDYPEGADSIYVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGW
HCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
AFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYPGVEISDNLEEVVRNADAIVVL
EEEECCCCCCCCCCCHHHHHHHHCCCEEEEECCEEEECCCCCCCCCHHHHHCCCCEEEEE
AGHSAYSSLKADWAKKVSAKANPVIIDGRNVIEPDEFIGKGFVYKGIGRGDKNSHKIK
ECCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MISMSKLEKLLKERGPIKKIGVLGMGYVGIPAAVLFADAPCFEKVLGFQRNSKSSGYKIE
CCCHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEE
MLNRGESPLKGEEPGLEELIGKVVKAGKFECTPDFSRISELDAVTLAIQTPFANPKDLEP
EECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCEEEEEEECCCCCCCCCCC
DFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQILEEESGLKAGEDFALAHAPE
CHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCH
RVMVGRLLKNIREHDRIVGGIDEASTKRAVELYSPVLTVGQVIPMSATAAEVTKTAENTF
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RDLQIAAINQLALYCEAMGINVYDVRTGVDSLKGEGITRAVLWPGAGVGGHCLTKDTYHL
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHH
ERGVKIGRGELDYPEGADSIYVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGW
HCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
AFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYPGVEISDNLEEVVRNADAIVVL
EEEECCCCCCCCCCCHHHHHHHHCCCEEEEECCEEEECCCCCCCCCHHHHHCCCCEEEEE
AGHSAYSSLKADWAKKVSAKANPVIIDGRNVIEPDEFIGKGFVYKGIGRGDKNSHKIK
ECCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA