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The map label for this gene is ArgD2

Identifier: 20808850

GI number: 20808850

Start: 2384432

End: 2385613

Strand: Reverse

Name: ArgD2

Synonym: TTE2495

Alternate gene names: 20808850

Gene position: 2385613-2384432 (Counterclockwise)

Preceding gene: 20808851

Following gene: 20808849

Centisome position: 88.7

GC content: 41.29

Gene sequence:

>1182_bases
ATGATAACCTATGAAAAGAAATATTTGATGGATACTTACAATAGATATCCTATTATGCTTGTCAAGGGAGAAGGTACAAG
AGTATGGGATAGTGAGGGAAATGCTTACCTCGACTTCGTGGCAGGTATTGCTGTGAATTCTTTGGGGCACTGTCATCCTG
CACTGGTCGAAGCTATTAAAAAGCAAGCAGAGACTTTAATTCACTGTTCAAATCTTTACTGGAATGAAAAGCAGATAGAG
CTTGCCAGAATGATTTCAGAAAATTCTTTTGGAGGGAAGGTGTTTTTTGCGAACAGCGGTGCAGAGGCAAATGAGGGGGC
TATAAAGCTTGCTAGAAAGTACGCCTCGTTAAAATACGGCGGCAAAAGGTATAAAATCATAACCGCCAAAAATTCCTTTC
ACGGGAGGACATTTGGAGCGCTTACTGCGACAGGGCAAGAGAAGTATCACAAAGGTTTTGGACCGCTCCTTGCCGGGTTT
AAATATGTGCCTTTAAATGACATTGAGGCCCTTTATGAGGCTGTCGACGATGAAGTGTGTGCAATTATGCTCGAGGTTAT
CCAGGGGGAAGGAGGTATCCATGAGGCTACACCAGAGTATGTAAAAGCGGTAAGGAAGATATGCGATGAAAATGACCTCC
TGTTTATATTGGATGAGGTTCAGACAGGAATAGGGCGTACAGGAAAGCTTTTCGGATATGAGCATTACGGTGTAGTTCCA
GACATTATGACTTTAGCCAAAGGGCTAGGAGGTGGTTTTCCGATAGGAGCGATAGTAGCAAAAGAAGATAAAGCTGTTTT
TAAGCCAGGAGATCACGCTTCTACTTTTGGCGGTAATCCTCTAGCTTGTGCGGCTGGGATTGCAGTATTAAATGAGGTGA
CAAAGGATGGATTTTTAGAAGGTGTTGATAAAAAAGGCAAATATTTTAGAGAAGGGCTAGAAACTTTGCAAAAGAAACAT
AAAGTCGTGAAAGAAATAAGAGGAAAAGGACTTATGGTGGGATGTGAAGTGGATTTGGAGGATGCATCGGAGATTGTTTT
AAAAGCACTTGAAAAAGGACTTTTAATAAATTCCGTAAGTCACAATGTCTTGAGGTTTGTACCTCCACTCATCGTGACGG
AGGAAGAAATTGATGAAGCTTTACAGATACTAGATGATGTGCTTAGTGAGATAAGATTTTAA

Upstream 100 bases:

>100_bases
AGGGCACACATAATAGATGGAAGGCTTACCCATTCTCTTCTTTTAGAAATTTTTACGGATGAGGGGATAGGGACAATGAT
AGGAAAGGAATGTTTTGATG

Downstream 100 bases:

>100_bases
ACTTGCTACTCTTAAAATTATCAACGATTTTGCCTGAAAAGTCGGTGTTGATAGATAAGTATATAGAGAGCGAAAAGGCA
ATATAGAAAATTCTCTTTCG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MITYEKKYLMDTYNRYPIMLVKGEGTRVWDSEGNAYLDFVAGIAVNSLGHCHPALVEAIKKQAETLIHCSNLYWNEKQIE
LARMISENSFGGKVFFANSGAEANEGAIKLARKYASLKYGGKRYKIITAKNSFHGRTFGALTATGQEKYHKGFGPLLAGF
KYVPLNDIEALYEAVDDEVCAIMLEVIQGEGGIHEATPEYVKAVRKICDENDLLFILDEVQTGIGRTGKLFGYEHYGVVP
DIMTLAKGLGGGFPIGAIVAKEDKAVFKPGDHASTFGGNPLACAAGIAVLNEVTKDGFLEGVDKKGKYFREGLETLQKKH
KVVKEIRGKGLMVGCEVDLEDASEIVLKALEKGLLINSVSHNVLRFVPPLIVTEEEIDEALQILDDVLSEIRF

Sequences:

>Translated_393_residues
MITYEKKYLMDTYNRYPIMLVKGEGTRVWDSEGNAYLDFVAGIAVNSLGHCHPALVEAIKKQAETLIHCSNLYWNEKQIE
LARMISENSFGGKVFFANSGAEANEGAIKLARKYASLKYGGKRYKIITAKNSFHGRTFGALTATGQEKYHKGFGPLLAGF
KYVPLNDIEALYEAVDDEVCAIMLEVIQGEGGIHEATPEYVKAVRKICDENDLLFILDEVQTGIGRTGKLFGYEHYGVVP
DIMTLAKGLGGGFPIGAIVAKEDKAVFKPGDHASTFGGNPLACAAGIAVLNEVTKDGFLEGVDKKGKYFREGLETLQKKH
KVVKEIRGKGLMVGCEVDLEDASEIVLKALEKGLLINSVSHNVLRFVPPLIVTEEEIDEALQILDDVLSEIRF
>Mature_393_residues
MITYEKKYLMDTYNRYPIMLVKGEGTRVWDSEGNAYLDFVAGIAVNSLGHCHPALVEAIKKQAETLIHCSNLYWNEKQIE
LARMISENSFGGKVFFANSGAEANEGAIKLARKYASLKYGGKRYKIITAKNSFHGRTFGALTATGQEKYHKGFGPLLAGF
KYVPLNDIEALYEAVDDEVCAIMLEVIQGEGGIHEATPEYVKAVRKICDENDLLFILDEVQTGIGRTGKLFGYEHYGVVP
DIMTLAKGLGGGFPIGAIVAKEDKAVFKPGDHASTFGGNPLACAAGIAVLNEVTKDGFLEGVDKKGKYFREGLETLQKKH
KVVKEIRGKGLMVGCEVDLEDASEIVLKALEKGLLINSVSHNVLRFVPPLIVTEEEIDEALQILDDVLSEIRF

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=392, Percent_Identity=37.5, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=38.7959866220736, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=29.0909090909091, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=29.9043062200957, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=29.6103896103896, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=25.7756563245823, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=28.9473684210526, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI188536080, Length=429, Percent_Identity=25.8741258741259, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI38679950, Length=429, Percent_Identity=25.8741258741259, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI38679946, Length=429, Percent_Identity=25.8741258741259, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=43.9276485788114, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1788044, Length=386, Percent_Identity=43.5233160621762, Blast_Score=345, Evalue=2e-96,
Organism=Escherichia coli, GI145693181, Length=387, Percent_Identity=37.7260981912145, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=34.1463414634146, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=35.75, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1786349, Length=312, Percent_Identity=32.6923076923077, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=28.2973621103118, Blast_Score=131, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=386, Percent_Identity=38.860103626943, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI25144274, Length=263, Percent_Identity=39.1634980988593, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=31.8807339449541, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=30.9302325581395, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71981843, Length=167, Percent_Identity=37.7245508982036, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=437, Percent_Identity=27.9176201372998, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=407, Percent_Identity=39.0663390663391, Blast_Score=285, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=34.9753694581281, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324386, Length=471, Percent_Identity=26.963906581741, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321456, Length=425, Percent_Identity=25.6470588235294, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21357415, Length=386, Percent_Identity=38.3419689119171, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=32.1678321678322, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=32.0185614849188, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=29.0094339622642, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281366494, Length=427, Percent_Identity=27.8688524590164, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24667139, Length=427, Percent_Identity=27.8688524590164, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24667143, Length=427, Percent_Identity=27.8688524590164, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_THETN (Q8R7C1)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624021.1
- ProteinModelPortal:   Q8R7C1
- SMR:   Q8R7C1
- GeneID:   998005
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2495
- NMPDR:   fig|273068.3.peg.1893
- HOGENOM:   HBG725944
- OMA:   GYEQLGI
- ProtClustDB:   PRK02627
- BioCyc:   TTEN273068:TTE2495-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 43161; Mature: 43161

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 133-133 BINDING 136-136 BINDING 274-274 BINDING 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITYEKKYLMDTYNRYPIMLVKGEGTRVWDSEGNAYLDFVAGIAVNSLGHCHPALVEAIK
CCCCCHHHHHHCCCCCEEEEEECCCCEEECCCCCEEHHHHHHHHHHCCCCCCHHHHHHHH
KQAETLIHCSNLYWNEKQIELARMISENSFGGKVFFANSGAEANEGAIKLARKYASLKYG
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
GKRYKIITAKNSFHGRTFGALTATGQEKYHKGFGPLLAGFKYVPLNDIEALYEAVDDEVC
CEEEEEEEECCCCCCCEEEEEEECCHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHH
AIMLEVIQGEGGIHEATPEYVKAVRKICDENDLLFILDEVQTGIGRTGKLFGYEHYGVVP
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCHH
DIMTLAKGLGGGFPIGAIVAKEDKAVFKPGDHASTFGGNPLACAAGIAVLNEVTKDGFLE
HHHHHHHHCCCCCCCCEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GVDKKGKYFREGLETLQKKHKVVKEIRGKGLMVGCEVDLEDASEIVLKALEKGLLINSVS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEHHHH
HNVLRFVPPLIVTEEEIDEALQILDDVLSEIRF
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITYEKKYLMDTYNRYPIMLVKGEGTRVWDSEGNAYLDFVAGIAVNSLGHCHPALVEAIK
CCCCCHHHHHHCCCCCEEEEEECCCCEEECCCCCEEHHHHHHHHHHCCCCCCHHHHHHHH
KQAETLIHCSNLYWNEKQIELARMISENSFGGKVFFANSGAEANEGAIKLARKYASLKYG
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
GKRYKIITAKNSFHGRTFGALTATGQEKYHKGFGPLLAGFKYVPLNDIEALYEAVDDEVC
CEEEEEEEECCCCCCCEEEEEEECCHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHH
AIMLEVIQGEGGIHEATPEYVKAVRKICDENDLLFILDEVQTGIGRTGKLFGYEHYGVVP
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCHH
DIMTLAKGLGGGFPIGAIVAKEDKAVFKPGDHASTFGGNPLACAAGIAVLNEVTKDGFLE
HHHHHHHHCCCCCCCCEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GVDKKGKYFREGLETLQKKHKVVKEIRGKGLMVGCEVDLEDASEIVLKALEKGLLINSVS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEHHHH
HNVLRFVPPLIVTEEEIDEALQILDDVLSEIRF
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336