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The map label for this gene is ArgG [H]

Identifier: 20808849

GI number: 20808849

Start: 2383084

End: 2384316

Strand: Reverse

Name: ArgG [H]

Synonym: TTE2494

Alternate gene names: 20808849

Gene position: 2384316-2383084 (Counterclockwise)

Preceding gene: 20808850

Following gene: 20808848

Centisome position: 88.65

GC content: 38.52

Gene sequence:

>1233_bases
ATGTTAAAAGGTGAAAAAGTGGTACTGGCATATTCGGGAGGACTTGACACCTCAGTGATTATACCATGGTTAAAAGAAAA
TTATGAATGTGAAATAATAGCGGTATGCGTGGATGTAGGGCAAAGGGAAGACCTAAGGTATATAAAAGATAAAGCTTTAG
CAAGTGGTGCCAGCAAAGTATATATTGAAGATGTCAAAGAGGAGTTTGTAAAAGACTATATATTTCCTACATTAAAAGCG
GGGGCTATATATGAAGGAAAATACCTTCTGGGAACTTCAATGGCAAGGCCTTTAATTGCCAAAAAACTTGTAGAAATTGC
TCACAAGGAAGGTGCCAAGGCGATAGCCCATGGTGCGACAGGCAAAGGCAATGACCAGGTGAGGTTTGAAGTTTCAATAC
GTGCTCTTGATCCTTCAATAAAAATAATAGCACCATGGAGAATATGGGAATTAAAATCGAGGGAAGATGAAATAGAATAT
GCTAAAAAGAAAGGAATACCTATTCCTGTAACTAAAGAAAAAATATACAGTGTAGACAGCAATCTGTGGCATGTGAGTCA
TGAGGGAGGAGACCTTGAAGACCCGTGGAATGAGCCTAAAAGTGATATTTACGATATAGTTACTCCTCCAGAGAAAGTCT
CAGATAAGCCGGAATATGTCTATATAGAGTTTGAAAAGGGCATTCCTGTAAAGGTAAATGGAAAAACGCTAAGCCCTGTC
AAATTAATAGAAGAATTAAATGAAATTGGAGGAAGAAATGGGGTAGGGATAGTTGACCTTGTTGAAAATAGACTTGTAGG
AATGAAATCTCGTGGTGTTTACGAGACTCCTGCAGGAACGTTACTTTATATTGCTCACAGAGAACTTGAGTACCTTGTAC
TTGATAAAGAAACGATGAGGTTTAAAGAGTTGGTAGCACAGAAATATGCGGATCTGGTCTATAACGGCCTCTGGTTTTCA
CCTCTCAAAACAGCTTTGGATGCTTTTATTGATGAGACGCAGAAAAATGTAACGGGTGTTGTAAGGCTAAAGCTTTATAA
AGGAAATGTCATAAATGCGGGTGCAAAATCTCCCTATTCTCTTTACAACGAAGAATTCGCAACTTTTGGTAAAGATGAAG
TTTACAACCAAAAAGACGCAGAAGGATTTATAAACCTCTTTGGGCTTTCTTTAAAAATTAGGGCTTTGATGGAAATGGGA
AGGAAGGATATGGATGAAGCTGTGGGGAGGTAG

Upstream 100 bases:

>100_bases
AATTATCAACGATTTTGCCTGAAAAGTCGGTGTTGATAGATAAGTATATAGAGAGCGAAAAGGCAATATAGAAAATTCTC
TTTCGTGAGGAGTGTGAAAA

Downstream 100 bases:

>100_bases
GTTTAAAAAGGACTTGGACAAACTGATGGAGGATTTCAATTCCTCCATTTCTTTTGATATAAGGCTTTTAAAGTATGATA
TAATGGGCTCTATTGCCCAT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLKGEKVVLAYSGGLDTSVIIPWLKENYECEIIAVCVDVGQREDLRYIKDKALASGASKVYIEDVKEEFVKDYIFPTLKA
GAIYEGKYLLGTSMARPLIAKKLVEIAHKEGAKAIAHGATGKGNDQVRFEVSIRALDPSIKIIAPWRIWELKSREDEIEY
AKKKGIPIPVTKEKIYSVDSNLWHVSHEGGDLEDPWNEPKSDIYDIVTPPEKVSDKPEYVYIEFEKGIPVKVNGKTLSPV
KLIEELNEIGGRNGVGIVDLVENRLVGMKSRGVYETPAGTLLYIAHRELEYLVLDKETMRFKELVAQKYADLVYNGLWFS
PLKTALDAFIDETQKNVTGVVRLKLYKGNVINAGAKSPYSLYNEEFATFGKDEVYNQKDAEGFINLFGLSLKIRALMEMG
RKDMDEAVGR

Sequences:

>Translated_410_residues
MLKGEKVVLAYSGGLDTSVIIPWLKENYECEIIAVCVDVGQREDLRYIKDKALASGASKVYIEDVKEEFVKDYIFPTLKA
GAIYEGKYLLGTSMARPLIAKKLVEIAHKEGAKAIAHGATGKGNDQVRFEVSIRALDPSIKIIAPWRIWELKSREDEIEY
AKKKGIPIPVTKEKIYSVDSNLWHVSHEGGDLEDPWNEPKSDIYDIVTPPEKVSDKPEYVYIEFEKGIPVKVNGKTLSPV
KLIEELNEIGGRNGVGIVDLVENRLVGMKSRGVYETPAGTLLYIAHRELEYLVLDKETMRFKELVAQKYADLVYNGLWFS
PLKTALDAFIDETQKNVTGVVRLKLYKGNVINAGAKSPYSLYNEEFATFGKDEVYNQKDAEGFINLFGLSLKIRALMEMG
RKDMDEAVGR
>Mature_410_residues
MLKGEKVVLAYSGGLDTSVIIPWLKENYECEIIAVCVDVGQREDLRYIKDKALASGASKVYIEDVKEEFVKDYIFPTLKA
GAIYEGKYLLGTSMARPLIAKKLVEIAHKEGAKAIAHGATGKGNDQVRFEVSIRALDPSIKIIAPWRIWELKSREDEIEY
AKKKGIPIPVTKEKIYSVDSNLWHVSHEGGDLEDPWNEPKSDIYDIVTPPEKVSDKPEYVYIEFEKGIPVKVNGKTLSPV
KLIEELNEIGGRNGVGIVDLVENRLVGMKSRGVYETPAGTLLYIAHRELEYLVLDKETMRFKELVAQKYADLVYNGLWFS
PLKTALDAFIDETQKNVTGVVRLKLYKGNVINAGAKSPYSLYNEEFATFGKDEVYNQKDAEGFINLFGLSLKIRALMEMG
RKDMDEAVGR

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=395, Percent_Identity=50.126582278481, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI16950633, Length=395, Percent_Identity=50.126582278481, Blast_Score=373, Evalue=1e-103,
Organism=Escherichia coli, GI1789563, Length=365, Percent_Identity=32.0547945205479, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324514, Length=408, Percent_Identity=42.6470588235294, Blast_Score=316, Evalue=4e-87,
Organism=Drosophila melanogaster, GI21358151, Length=407, Percent_Identity=43.2432432432432, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 46096; Mature: 46096

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGEKVVLAYSGGLDTSVIIPWLKENYECEIIAVCVDVGQREDLRYIKDKALASGASKV
CCCCCEEEEEECCCCCCEEEEEHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEE
YIEDVKEEFVKDYIFPTLKAGAIYEGKYLLGTSMARPLIAKKLVEIAHKEGAKAIAHGAT
HHHHHHHHHHHHHHCCCCCCCEEECCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
GKGNDQVRFEVSIRALDPSIKIIAPWRIWELKSREDEIEYAKKKGIPIPVTKEKIYSVDS
CCCCCEEEEEEEEEEECCCEEEEECEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHCCCC
NLWHVSHEGGDLEDPWNEPKSDIYDIVTPPEKVSDKPEYVYIEFEKGIPVKVNGKTLSPV
CEEEEECCCCCCCCCCCCCCHHHEECCCCHHHHCCCCCEEEEEECCCCCEEECCCCCCHH
KLIEELNEIGGRNGVGIVDLVENRLVGMKSRGVYETPAGTLLYIAHRELEYLVLDKETMR
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEECCCCEEEEEEECCEEEEEECHHHHH
FKELVAQKYADLVYNGLWFSPLKTALDAFIDETQKNVTGVVRLKLYKGNVINAGAKSPYS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCEEECCCCCCHH
LYNEEFATFGKDEVYNQKDAEGFINLFGLSLKIRALMEMGRKDMDEAVGR
HHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MLKGEKVVLAYSGGLDTSVIIPWLKENYECEIIAVCVDVGQREDLRYIKDKALASGASKV
CCCCCEEEEEECCCCCCEEEEEHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEE
YIEDVKEEFVKDYIFPTLKAGAIYEGKYLLGTSMARPLIAKKLVEIAHKEGAKAIAHGAT
HHHHHHHHHHHHHHCCCCCCCEEECCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
GKGNDQVRFEVSIRALDPSIKIIAPWRIWELKSREDEIEYAKKKGIPIPVTKEKIYSVDS
CCCCCEEEEEEEEEEECCCEEEEECEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHCCCC
NLWHVSHEGGDLEDPWNEPKSDIYDIVTPPEKVSDKPEYVYIEFEKGIPVKVNGKTLSPV
CEEEEECCCCCCCCCCCCCCHHHEECCCCHHHHCCCCCEEEEEECCCCCEEECCCCCCHH
KLIEELNEIGGRNGVGIVDLVENRLVGMKSRGVYETPAGTLLYIAHRELEYLVLDKETMR
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEECCCCEEEEEEECCEEEEEECHHHHH
FKELVAQKYADLVYNGLWFSPLKTALDAFIDETQKNVTGVVRLKLYKGNVINAGAKSPYS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCEEECCCCCCHH
LYNEEFATFGKDEVYNQKDAEGFINLFGLSLKIRALMEMGRKDMDEAVGR
HHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA