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The map label for this gene is hisD

Identifier: 20808528

GI number: 20808528

Start: 2053862

End: 2055154

Strand: Reverse

Name: hisD

Synonym: TTE2138

Alternate gene names: 20808528

Gene position: 2055154-2053862 (Counterclockwise)

Preceding gene: 20808529

Following gene: 20808527

Centisome position: 76.42

GC content: 36.19

Gene sequence:

>1293_bases
ATGATAGAAATGTTTGATTTTACTAAGGAAGTCGATATAGGGATTTTTAATAAAATACAGAATAGAAGTAAATTGGAGAA
TAAAGAGATTGCAAAAAGGGTTGAAGACATAATAGAAAATGTGAGAGAGAGGAAGGATAAAGCGTTATTTGAATACACCT
ATATGTATGATGGAATAAATCTCAATAGCGAGACAGTGAAGGTAAAAGAGGAAGAAATAAAAAGAGCTTATGAGGAAGTG
AAAGAGGATTTTTTAAAAGCGTTAGATAAGGCCATAAAAAATATTACGGAGTTTCATGAGAAGCAAAAGGAAAAGACATG
GATGGATTTTAAAGAAGGAATAGTTTACGGGCAAGTATTAAGGCCTCTTTCCTCTGTAGGCATTTATGTTCCTGGAGGAA
CTGCCTCATATCCTTCTTCAGTTTTGATGAATGGTATTCCTGCAAAGGTGGCAGGCGTTGAAAGAATAGTAATGGTATCT
CCTGCTGGAAAAAAGGGGATAAGCCCTTATGTGCTTGTGGCGGCAGATAAAATTGGAATAAAAGAAATATATAAAATTGG
CGGAGCACAGGCTGTTGCAGCACTGGCTTTTGGCACAGAATCAATACCTAAGGTGGACAAAATAGTTGGTCCAGGAAATA
TTTATGTAGCAATGGCAAAAAGAGCCCTATATGGCTATGTAGACATAGACATGGTGGCAGGACCTAGTGAAATTTTGGTA
ATTGCAGATGAGTCAGCAAGTCCAAAATATGTAGCAGCAGACCTTCTTTCACAGGCAGAACACGATGTAATGGCTTCTTC
AATATTAGTGACAACCTCAAAAGAGTTAGCGGAAAAAGTAAAAAAAGAAATTGAAAGACAAATGGAATATCTTGAGCGAA
AAGAAATAATTGCAGAGTCTTTAAAAAATTTTGGCGCGATAATTGTTATAGATAATTTAAAAGAAGCAATTGGTATTGCA
AATGAAATAGCTCCAGAGCATTTAGAGCTTGTCATTGAAAATCCTTTTGAAATTTTAGGCGAAATTAAAAATGCAGGAGC
AGTATTTTTAGGAGAATTTTCTCCAGAACCTTTGGGAGACTACCTTGCAGGTCCAAATCATGTTCTTCCTACAAGTGGTA
CAGCGAGATTTTTCTCTCCTCTTTCAGTTAGGGATTTTGTCAAAAAGATGAATGTACTTTATTACTCTAAGGAAGCTTTG
AGCAGTGTAAAAGATGATGTCATAACCTTGGCAGAAGCTGAAGAGCTTACAGCCCATGCCAATTCTGTAAAAGTGAGGTT
TTACAATGATTGA

Upstream 100 bases:

>100_bases
CAGCGAGACTTATAGTTAACAAGGCAAGCATGAAGACAAAAAGCGAGAGAATAAAGGATATAATTTTAAAGCTGAGAGAA
GTTATAAATGGGGGATAGAG

Downstream 100 bases:

>100_bases
GAATTTGTTGAGGGAAGAAATTAAAGGATTTAAAAATTATGAAGTGGAAAATGTGCCTTATAAATATAAGATGGATGCAA
ACGAGACCCCTTTTGAACTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGINLNSETVKVKEEEIKRAYEEV
KEDFLKALDKAIKNITEFHEKQKEKTWMDFKEGIVYGQVLRPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVS
PAGKKGISPYVLVAADKIGIKEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVDIDMVAGPSEILV
IADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAESLKNFGAIIVIDNLKEAIGIA
NEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGDYLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEAL
SSVKDDVITLAEAEELTAHANSVKVRFYND

Sequences:

>Translated_430_residues
MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGINLNSETVKVKEEEIKRAYEEV
KEDFLKALDKAIKNITEFHEKQKEKTWMDFKEGIVYGQVLRPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVS
PAGKKGISPYVLVAADKIGIKEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVDIDMVAGPSEILV
IADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAESLKNFGAIIVIDNLKEAIGIA
NEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGDYLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEAL
SSVKDDVITLAEAEELTAHANSVKVRFYND
>Mature_430_residues
MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGINLNSETVKVKEEEIKRAYEEV
KEDFLKALDKAIKNITEFHEKQKEKTWMDFKEGIVYGQVLRPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVS
PAGKKGISPYVLVAADKIGIKEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVDIDMVAGPSEILV
IADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAESLKNFGAIIVIDNLKEAIGIA
NEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGDYLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEAL
SSVKDDVITLAEAEELTAHANSVKVRFYND

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=404, Percent_Identity=44.5544554455446, Blast_Score=342, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=39.7228637413395, Blast_Score=294, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_THETN (Q8R882)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623699.1
- ProteinModelPortal:   Q8R882
- SMR:   Q8R882
- GeneID:   997457
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2138
- NMPDR:   fig|273068.3.peg.2242
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   TTEN273068:TTE2138-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47674; Mature: 47674

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00611 HISOL_DEHYDROGENASE; PS01095 CHITINASE_18

Important sites: ACT_SITE 326-326 ACT_SITE 327-327 BINDING 129-129 BINDING 190-190 BINDING 213-213 BINDING 236-236 BINDING 258-258 BINDING 261-261 BINDING 327-327 BINDING 360-360 BINDING 414-414 BINDING 419-419

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGIN
CCCHHCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
LNSETVKVKEEEIKRAYEEVKEDFLKALDKAIKNITEFHEKQKEKTWMDFKEGIVYGQVL
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVSPAGKKGISPYVLVAADKIGI
HHHHHCCEEECCCCCCCCHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCH
KEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVDIDMVAGPSEILV
HHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEHHHHHHCEEEEEEECCCCEEEE
IADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAES
EECCCCCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNFGAIIVIDNLKEAIGIANEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGD
HHHCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCHH
YLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEALSSVKDDVITLAEAEELTAHA
HCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
NSVKVRFYND
CEEEEEEECC
>Mature Secondary Structure
MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGIN
CCCHHCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
LNSETVKVKEEEIKRAYEEVKEDFLKALDKAIKNITEFHEKQKEKTWMDFKEGIVYGQVL
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVSPAGKKGISPYVLVAADKIGI
HHHHHCCEEECCCCCCCCHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCH
KEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVDIDMVAGPSEILV
HHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEHHHHHHCEEEEEEECCCCEEEE
IADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAES
EECCCCCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNFGAIIVIDNLKEAIGIANEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGD
HHHCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCCHH
YLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEALSSVKDDVITLAEAEELTAHA
HCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
NSVKVRFYND
CEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336