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The map label for this gene is HisC2

Identifier: 20808527

GI number: 20808527

Start: 2052814

End: 2053869

Strand: Reverse

Name: HisC2

Synonym: TTE2137

Alternate gene names: 20808527

Gene position: 2053869-2052814 (Counterclockwise)

Preceding gene: 20808528

Following gene: 20808526

Centisome position: 76.37

GC content: 32.58

Gene sequence:

>1056_bases
ATGATTGAGAATTTGTTGAGGGAAGAAATTAAAGGATTTAAAAATTATGAAGTGGAAAATGTGCCTTATAAATATAAGAT
GGATGCAAACGAGACCCCTTTTGAACTTCCTGAAGAGGTAATGAAAAATATAGGGGATATTGTAAAGTCTATCCATGTAA
ATATATATCCAGACCCTACGGCAGAAAAATTGAGAGAAGAGTTAGCGAGATATTGCAGTGTCACTCCTAAAAATATTTTT
GTAGGAAATGGTTCTGATGAAATAATACACCTTATAATGCTTGCCTTTGTAGATAAAGGGGATACAGTTTTGTACCCTCA
CCCATCTTTTGCAATGTACAGCATATACAGTAAAATTGCAGGAGCGAATGAAATAGCTGTGAATTTAAATGAGGACTATA
CTTATAATGTTGAAAGATTTGCAGAAGCAGTTGAAAGATATAAGCCTAAATTGGTGTTTTTGTGCAATCCAAACAATCCC
ACTGGAAGCGTAATAGATGAAGAGGATATAATCAGAATAATTGAAAAAGCAAGAGGGATTGTAATAGTTGATGAAGCTTA
TTTTGAATTTTATGGAAAAACTCTTGTGCCATATATAGATAGATTTGAAAATTTGATTGTGCTGCGAACATTGTCAAAAG
CTTTTGGGATTGCAGGATTAAGAGTGGGATATGCTCTCTCAAATGGAGAAATAGTGAAATATTTAAATCTTGTAAAATCT
CCTTATAATCTCAACTCTTTATCACAGAGAATAGCATTAGAAGTTTTAAAAAGTGGTGTTTTAAAGGAGAGGGTAAATTA
CATTATAAACGAAAGAGAAAAGCTGGTAAAGGAGTTAAATAAAATTAATGGGATAAAAGTGTATCCTTCTCATGCAAATT
TTGTTCTTTGTAAATTTGAAAATGCCAATGATGTGCACAAAAGACTTGTTGAAAGGGGAATTTTGGTGAGAAATTTTTCT
AATGTGAAGGGGTTGGAAGGGACTTTAAGGATAACTGTGAGTTCTTCTGATGCCAATGATTATTTAATAAACGCTTTAAG
GGAGATATTGTCATGA

Upstream 100 bases:

>100_bases
TCTAAGGAAGCTTTGAGCAGTGTAAAAGATGATGTCATAACCTTGGCAGAAGCTGAAGAGCTTACAGCCCATGCCAATTC
TGTAAAAGTGAGGTTTTACA

Downstream 100 bases:

>100_bases
GGAAAGCGGAAGTTAAAAGAAAAACGGCAGAGACTGACATATATGTCGAACTTAATATAGATGGCAAAGGCTCATATGAT
ATAAAGACGGGAATAGGCTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MIENLLREEIKGFKNYEVENVPYKYKMDANETPFELPEEVMKNIGDIVKSIHVNIYPDPTAEKLREELARYCSVTPKNIF
VGNGSDEIIHLIMLAFVDKGDTVLYPHPSFAMYSIYSKIAGANEIAVNLNEDYTYNVERFAEAVERYKPKLVFLCNPNNP
TGSVIDEEDIIRIIEKARGIVIVDEAYFEFYGKTLVPYIDRFENLIVLRTLSKAFGIAGLRVGYALSNGEIVKYLNLVKS
PYNLNSLSQRIALEVLKSGVLKERVNYIINEREKLVKELNKINGIKVYPSHANFVLCKFENANDVHKRLVERGILVRNFS
NVKGLEGTLRITVSSSDANDYLINALREILS

Sequences:

>Translated_351_residues
MIENLLREEIKGFKNYEVENVPYKYKMDANETPFELPEEVMKNIGDIVKSIHVNIYPDPTAEKLREELARYCSVTPKNIF
VGNGSDEIIHLIMLAFVDKGDTVLYPHPSFAMYSIYSKIAGANEIAVNLNEDYTYNVERFAEAVERYKPKLVFLCNPNNP
TGSVIDEEDIIRIIEKARGIVIVDEAYFEFYGKTLVPYIDRFENLIVLRTLSKAFGIAGLRVGYALSNGEIVKYLNLVKS
PYNLNSLSQRIALEVLKSGVLKERVNYIINEREKLVKELNKINGIKVYPSHANFVLCKFENANDVHKRLVERGILVRNFS
NVKGLEGTLRITVSSSDANDYLINALREILS
>Mature_351_residues
MIENLLREEIKGFKNYEVENVPYKYKMDANETPFELPEEVMKNIGDIVKSIHVNIYPDPTAEKLREELARYCSVTPKNIF
VGNGSDEIIHLIMLAFVDKGDTVLYPHPSFAMYSIYSKIAGANEIAVNLNEDYTYNVERFAEAVERYKPKLVFLCNPNNP
TGSVIDEEDIIRIIEKARGIVIVDEAYFEFYGKTLVPYIDRFENLIVLRTLSKAFGIAGLRVGYALSNGEIVKYLNLVKS
PYNLNSLSQRIALEVLKSGVLKERVNYIINEREKLVKELNKINGIKVYPSHANFVLCKFENANDVHKRLVERGILVRNFS
NVKGLEGTLRITVSSSDANDYLINALREILS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=333, Percent_Identity=34.2342342342342, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1788722, Length=258, Percent_Identity=28.2945736434109, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788627, Length=166, Percent_Identity=27.1084337349398, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=178, Percent_Identity=25.2808988764045, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=362, Percent_Identity=30.939226519337, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322401, Length=252, Percent_Identity=24.6031746031746, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_THETN (Q8R5Q4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623698.1
- ProteinModelPortal:   Q8R5Q4
- SMR:   Q8R5Q4
- GeneID:   997450
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2137
- NMPDR:   fig|273068.3.peg.2241
- HOGENOM:   HBG646350
- OMA:   IMRVIAP
- ProtClustDB:   PRK14807
- BioCyc:   TTEN273068:TTE2137-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40032; Mature: 40032

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENLLREEIKGFKNYEVENVPYKYKMDANETPFELPEEVMKNIGDIVKSIHVNIYPDPT
CHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCC
AEKLREELARYCSVTPKNIFVGNGSDEIIHLIMLAFVDKGDTVLYPHPSFAMYSIYSKIA
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHC
GANEIAVNLNEDYTYNVERFAEAVERYKPKLVFLCNPNNPTGSVIDEEDIIRIIEKARGI
CCCEEEEECCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCE
VIVDEAYFEFYGKTLVPYIDRFENLIVLRTLSKAFGIAGLRVGYALSNGEIVKYLNLVKS
EEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHCC
PYNLNSLSQRIALEVLKSGVLKERVNYIINEREKLVKELNKINGIKVYPSHANFVLCKFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEC
NANDVHKRLVERGILVRNFSNVKGLEGTLRITVSSSDANDYLINALREILS
CCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MIENLLREEIKGFKNYEVENVPYKYKMDANETPFELPEEVMKNIGDIVKSIHVNIYPDPT
CHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCC
AEKLREELARYCSVTPKNIFVGNGSDEIIHLIMLAFVDKGDTVLYPHPSFAMYSIYSKIA
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHC
GANEIAVNLNEDYTYNVERFAEAVERYKPKLVFLCNPNNPTGSVIDEEDIIRIIEKARGI
CCCEEEEECCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCE
VIVDEAYFEFYGKTLVPYIDRFENLIVLRTLSKAFGIAGLRVGYALSNGEIVKYLNLVKS
EEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHCC
PYNLNSLSQRIALEVLKSGVLKERVNYIINEREKLVKELNKINGIKVYPSHANFVLCKFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEC
NANDVHKRLVERGILVRNFSNVKGLEGTLRITVSSSDANDYLINALREILS
CCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336