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The map label for this gene is hisG

Identifier: 20808529

GI number: 20808529

Start: 2055157

End: 2055789

Strand: Reverse

Name: hisG

Synonym: TTE2139

Alternate gene names: 20808529

Gene position: 2055789-2055157 (Counterclockwise)

Preceding gene: 20808530

Following gene: 20808528

Centisome position: 76.44

GC content: 34.28

Gene sequence:

>633_bases
ATGGATATTGTTTCAATAGCTTTGCCAAAGGGCAGGATGACAGAGGATGCAGTAGTTTTATTTAAAAAAGCAGGTATTTC
TAATGATGTGTTAAAAGATATATCGAGGAAGTTAATTTTAGAAGATAATAAAAATGCTATAAAGTTTATGCTTGTAAAAC
CTATGGATGTTCCAACTTATGTGGAGCACGGTGCAGCAGATTTAGGGGTTTGTGGAAAGGATATTTTGTTGGAGCAAAAA
AAGGATTTATACGAAGTTTTAGATTTAAAATTTGGATTTTGCAGAATGGTAGTAGCTGGTCCTCCCAATGTTAAAGACAG
CTTTCTCACAAATAAAAGAGTTGCTACTAAATTTCCAAACGTTGCAGAGGAATTTTTTAAGAAAAAAGGTGAAAATGTTG
AGATAATCAAATTAAATGGCTCTGTGGAGCTTGCTCCAATTGTAGGATTATCAGAAGTGATTGTTGATATTGTGGAGACT
GGAAGGACTTTAAGAGAGAATGGCCTTGTTGTTATAGAGGAGATTTTTCCTTCAACAGCGAGACTTATAGTTAACAAGGC
AAGCATGAAGACAAAAAGCGAGAGAATAAAGGATATAATTTTAAAGCTGAGAGAAGTTATAAATGGGGGATAG

Upstream 100 bases:

>100_bases
CTCAGAAAAGAAGGCAATGTCGTAGAGATGTACACTTTTAAGAGGTGTGAAAATATTGATTTAAAAAGTTTTGATGAAGT
CGTAGATGTGGGGGAATGAC

Downstream 100 bases:

>100_bases
AGATGATAGAAATGTTTGATTTTACTAAGGAAGTCGATATAGGGATTTTTAATAAAATACAGAATAGAAGTAAATTGGAG
AATAAAGAGATTGCAAAAAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MDIVSIALPKGRMTEDAVVLFKKAGISNDVLKDISRKLILEDNKNAIKFMLVKPMDVPTYVEHGAADLGVCGKDILLEQK
KDLYEVLDLKFGFCRMVVAGPPNVKDSFLTNKRVATKFPNVAEEFFKKKGENVEIIKLNGSVELAPIVGLSEVIVDIVET
GRTLRENGLVVIEEIFPSTARLIVNKASMKTKSERIKDIILKLREVINGG

Sequences:

>Translated_210_residues
MDIVSIALPKGRMTEDAVVLFKKAGISNDVLKDISRKLILEDNKNAIKFMLVKPMDVPTYVEHGAADLGVCGKDILLEQK
KDLYEVLDLKFGFCRMVVAGPPNVKDSFLTNKRVATKFPNVAEEFFKKKGENVEIIKLNGSVELAPIVGLSEVIVDIVET
GRTLRENGLVVIEEIFPSTARLIVNKASMKTKSERIKDIILKLREVINGG
>Mature_210_residues
MDIVSIALPKGRMTEDAVVLFKKAGISNDVLKDISRKLILEDNKNAIKFMLVKPMDVPTYVEHGAADLGVCGKDILLEQK
KDLYEVLDLKFGFCRMVVAGPPNVKDSFLTNKRVATKFPNVAEEFFKKKGENVEIIKLNGSVELAPIVGLSEVIVDIVET
GRTLRENGLVVIEEIFPSTARLIVNKASMKTKSERIKDIILKLREVINGG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=222, Percent_Identity=32.4324324324324, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_THETN (Q8R881)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623700.1
- ProteinModelPortal:   Q8R881
- SMR:   Q8R881
- GeneID:   997459
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2139
- NMPDR:   fig|273068.3.peg.2243
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   TTEN273068:TTE2139-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23283; Mature: 23283

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVSIALPKGRMTEDAVVLFKKAGISNDVLKDISRKLILEDNKNAIKFMLVKPMDVPTY
CCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCEEEEEEECCCCCCHH
VEHGAADLGVCGKDILLEQKKDLYEVLDLKFGFCRMVVAGPPNVKDSFLTNKRVATKFPN
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCHHHHCCCH
VAEEFFKKKGENVEIIKLNGSVELAPIVGLSEVIVDIVETGRTLRENGLVVIEEIFPSTA
HHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHCCCHHHHCCCEEEHHHCCHHH
RLIVNKASMKTKSERIKDIILKLREVINGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDIVSIALPKGRMTEDAVVLFKKAGISNDVLKDISRKLILEDNKNAIKFMLVKPMDVPTY
CCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCEEEEEEECCCCCCHH
VEHGAADLGVCGKDILLEQKKDLYEVLDLKFGFCRMVVAGPPNVKDSFLTNKRVATKFPN
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCHHHHCCCH
VAEEFFKKKGENVEIIKLNGSVELAPIVGLSEVIVDIVETGRTLRENGLVVIEEIFPSTA
HHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHCCCHHHHCCCEEEHHHCCHHH
RLIVNKASMKTKSERIKDIILKLREVINGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336