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The map label for this gene is FtsI5 [H]

Identifier: 20808371

GI number: 20808371

Start: 1913396

End: 1914820

Strand: Reverse

Name: FtsI5 [H]

Synonym: TTE1967

Alternate gene names: 20808371

Gene position: 1914820-1913396 (Counterclockwise)

Preceding gene: 20808372

Following gene: 20808370

Centisome position: 71.2

GC content: 42.32

Gene sequence:

>1425_bases
ATGTCCAATTTGAAGCGCAATATTAAAATACTCTTTGGAATCTTTGCCCTCCTCTTTTTTAGTTTGATTGCGTATTTGAC
ATATTTTCAACTGTATGAAAGGGATAAATTGATTACCAGCTCTTACAGCGTGTACAATAGAAGGCTTATAGAACAGGAAA
AGAAAATTTTAAGAGGTAGCATTCTTGATAGAAATGGCATTGTGCTTGCAAAAAGCGTGATAGAGGCTGATGGGACGCAA
AAGAGAATTTACCTGGATGGACCTGCCTTTGCGCAGGTGATAGGATATAGCCGCAGGATATACCAGCAGGGCAGTACTGG
AATTGAAAAGGCTTATGACAGGGAACTGCTTGGCATGGTAGGTTCTGACCCAATGGTGCTTTTGAGAAAACTTATTTTGG
GGAAAGGGCAGATAGGGGATAATGTCTACCTTACTATAGACAAGGCTCTTCAGGACTTGGCTTACAGGGAAATGGAGGGG
AAAAAGGGTGCTGTAGTCGCATTAAACCCTAAAACTGGGGAAATACTTGCTATGGTATCCACTCCTTCTTATGACCCTAA
CCTTCTCGATAGGGATTGGGAAAAAATAATGACAAGCCCTGAACATGTAGTTTTAAATAGAGCCACTCAAGGCCTCTATC
CTCCGGGGTCTACTTTTAAAATAATAACAACTGCTGCAGTTTTAACCTACATGCCAGAGCTCTTTAAAGAAGTGTACGAT
TGTAAAGGTTACGTGGTAGTGGATGGCAACAAGATAAGCGATTTTGGAGGTATTGCTCACGGTAAAGAAAATTTTGAGAG
AGCTTTTTATGTGTCCTGCAACTCTTTTTTCATAGAGATAGGGTTAAAGCTCGGTAGTGACAATTTGGAGAAGATGGCTT
ATGCTTTTGGCTTGAATCAGAGAGTTCCTTTAGAAATTGATACGGCGAAAAATTACTTTCCCTCAATTGATGGGAAAGTT
GCTCTGGCAGAAACTTCAATAGGGCAGGGGAAGATTCTCGTAACTCCTCTGACAATGGCTTTGGCTGCTTCTGCTGTTGC
CAATGATGGAGTCATAATGAAGCCCTATCTCATGAAATATGTGGTGGATCCTCTTTCAGGTGCTGTCATAGAGAGAAATA
CTCCCAGTAAGTATTTGACCCCCATAACAAAGGAAGTAGCTGATGCTATAAAAAGTCTCATGATAGGAGTTGTCAACAAT
CCTGAAGGGACTGGAAGATTAGCTCAGATACCGGGCATTACAGTGGCGGGGAAAACCGGCACTGCTGAAAATCCATTTGG
TGCTCCTCATGCCTGGTTTGTGGCCTTTGCACCTGCGGAAAATCCAGAGATAGCTGTAGCTGTGGTTGTTGAAAATGGCG
GGGAAGGTGGAAAAGTAGCAGCACCTATTGCAAGAGACATAATAAAGGCTTATCTTTCGAGGTGA

Upstream 100 bases:

>100_bases
GTTACTCTACCTTTTGTGAGCTACGGGGGAAGTTCAATGGTGATGAGCTTTTTTACACTGGGAATGCTAAACGGCATTTC
CGTCGGGGAGGAGGAAGAAG

Downstream 100 bases:

>100_bases
GAGAGGTGGATTTGCAGGAAAAGTTAAAGCTTTTGCCTGAAAAGCCTGGGGTATACCTGATGAAGGATGAGGAAGGGAAT
ATAATCTATGTGGGCAAAGC

Product: cell division protein FtsI/penicillin-binding protein 2

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSNLKRNIKILFGIFALLFFSLIAYLTYFQLYERDKLITSSYSVYNRRLIEQEKKILRGSILDRNGIVLAKSVIEADGTQ
KRIYLDGPAFAQVIGYSRRIYQQGSTGIEKAYDRELLGMVGSDPMVLLRKLILGKGQIGDNVYLTIDKALQDLAYREMEG
KKGAVVALNPKTGEILAMVSTPSYDPNLLDRDWEKIMTSPEHVVLNRATQGLYPPGSTFKIITTAAVLTYMPELFKEVYD
CKGYVVVDGNKISDFGGIAHGKENFERAFYVSCNSFFIEIGLKLGSDNLEKMAYAFGLNQRVPLEIDTAKNYFPSIDGKV
ALAETSIGQGKILVTPLTMALAASAVANDGVIMKPYLMKYVVDPLSGAVIERNTPSKYLTPITKEVADAIKSLMIGVVNN
PEGTGRLAQIPGITVAGKTGTAENPFGAPHAWFVAFAPAENPEIAVAVVVENGGEGGKVAAPIARDIIKAYLSR

Sequences:

>Translated_474_residues
MSNLKRNIKILFGIFALLFFSLIAYLTYFQLYERDKLITSSYSVYNRRLIEQEKKILRGSILDRNGIVLAKSVIEADGTQ
KRIYLDGPAFAQVIGYSRRIYQQGSTGIEKAYDRELLGMVGSDPMVLLRKLILGKGQIGDNVYLTIDKALQDLAYREMEG
KKGAVVALNPKTGEILAMVSTPSYDPNLLDRDWEKIMTSPEHVVLNRATQGLYPPGSTFKIITTAAVLTYMPELFKEVYD
CKGYVVVDGNKISDFGGIAHGKENFERAFYVSCNSFFIEIGLKLGSDNLEKMAYAFGLNQRVPLEIDTAKNYFPSIDGKV
ALAETSIGQGKILVTPLTMALAASAVANDGVIMKPYLMKYVVDPLSGAVIERNTPSKYLTPITKEVADAIKSLMIGVVNN
PEGTGRLAQIPGITVAGKTGTAENPFGAPHAWFVAFAPAENPEIAVAVVVENGGEGGKVAAPIARDIIKAYLSR
>Mature_473_residues
SNLKRNIKILFGIFALLFFSLIAYLTYFQLYERDKLITSSYSVYNRRLIEQEKKILRGSILDRNGIVLAKSVIEADGTQK
RIYLDGPAFAQVIGYSRRIYQQGSTGIEKAYDRELLGMVGSDPMVLLRKLILGKGQIGDNVYLTIDKALQDLAYREMEGK
KGAVVALNPKTGEILAMVSTPSYDPNLLDRDWEKIMTSPEHVVLNRATQGLYPPGSTFKIITTAAVLTYMPELFKEVYDC
KGYVVVDGNKISDFGGIAHGKENFERAFYVSCNSFFIEIGLKLGSDNLEKMAYAFGLNQRVPLEIDTAKNYFPSIDGKVA
LAETSIGQGKILVTPLTMALAASAVANDGVIMKPYLMKYVVDPLSGAVIERNTPSKYLTPITKEVADAIKSLMIGVVNNP
EGTGRLAQIPGITVAGKTGTAENPFGAPHAWFVAFAPAENPEIAVAVVVENGGEGGKVAAPIARDIIKAYLSR

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=469, Percent_Identity=29.4243070362473, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786272, Length=412, Percent_Identity=28.1553398058252, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 51839; Mature: 51708

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLKRNIKILFGIFALLFFSLIAYLTYFQLYERDKLITSSYSVYNRRLIEQEKKILRGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
ILDRNGIVLAKSVIEADGTQKRIYLDGPAFAQVIGYSRRIYQQGSTGIEKAYDRELLGMV
CCCCCCEEEEHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GSDPMVLLRKLILGKGQIGDNVYLTIDKALQDLAYREMEGKKGAVVALNPKTGEILAMVS
CCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEE
TPSYDPNLLDRDWEKIMTSPEHVVLNRATQGLYPPGSTFKIITTAAVLTYMPELFKEVYD
CCCCCCCCCHHHHHHHCCCCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
CKGYVVVDGNKISDFGGIAHGKENFERAFYVSCNSFFIEIGLKLGSDNLEKMAYAFGLNQ
CCCEEEECCCEECCCCCCCCCCCCCCEEEEEEECEEEEEEEEECCCCHHHHHHHHHCCCC
RVPLEIDTAKNYFPSIDGKVALAETSIGQGKILVTPLTMALAASAVANDGVIMKPYLMKY
CCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCEEEHHHHHHH
VVDPLSGAVIERNTPSKYLTPITKEVADAIKSLMIGVVNNPEGTGRLAQIPGITVAGKTG
HHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCEEEECCCC
TAENPFGAPHAWFVAFAPAENPEIAVAVVVENGGEGGKVAAPIARDIIKAYLSR
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNLKRNIKILFGIFALLFFSLIAYLTYFQLYERDKLITSSYSVYNRRLIEQEKKILRGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
ILDRNGIVLAKSVIEADGTQKRIYLDGPAFAQVIGYSRRIYQQGSTGIEKAYDRELLGMV
CCCCCCEEEEHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GSDPMVLLRKLILGKGQIGDNVYLTIDKALQDLAYREMEGKKGAVVALNPKTGEILAMVS
CCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEE
TPSYDPNLLDRDWEKIMTSPEHVVLNRATQGLYPPGSTFKIITTAAVLTYMPELFKEVYD
CCCCCCCCCHHHHHHHCCCCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
CKGYVVVDGNKISDFGGIAHGKENFERAFYVSCNSFFIEIGLKLGSDNLEKMAYAFGLNQ
CCCEEEECCCEECCCCCCCCCCCCCCEEEEEEECEEEEEEEEECCCCHHHHHHHHHCCCC
RVPLEIDTAKNYFPSIDGKVALAETSIGQGKILVTPLTMALAASAVANDGVIMKPYLMKY
CCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCEEEHHHHHHH
VVDPLSGAVIERNTPSKYLTPITKEVADAIKSLMIGVVNNPEGTGRLAQIPGITVAGKTG
HHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCEEEECCCC
TAENPFGAPHAWFVAFAPAENPEIAVAVVVENGGEGGKVAAPIARDIIKAYLSR
CCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA