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The map label for this gene is uvrC

Identifier: 20808370

GI number: 20808370

Start: 1911537

End: 1913390

Strand: Reverse

Name: uvrC

Synonym: TTE1966

Alternate gene names: 20808370

Gene position: 1913390-1911537 (Counterclockwise)

Preceding gene: 20808371

Following gene: 20808368

Centisome position: 71.14

GC content: 40.61

Gene sequence:

>1854_bases
GTGGATTTGCAGGAAAAGTTAAAGCTTTTGCCTGAAAAGCCTGGGGTATACCTGATGAAGGATGAGGAAGGGAATATAAT
CTATGTGGGCAAAGCCTCTGTTTTGAAAAACAGGGTTAGGCAGTACTTCCAAAACACAGACAATCATCCTCCAAAAGTGA
AAGTAATGCTTTCTCACGTGGAAGACTTTGAATACATCGTAACAGATACAGAGCTTGAGGCTTTGATGCTAGAGTGCAAC
CTCATTAAAAAATACAAGCCAAAGTACAACGTGCTTTTAAAAGACGACAAAAATTATCCCTATATAAAAATTACGGTGGC
AGAAGATTATCCCAGAATAATGTTCACAAGAAAAATAGACATGGACGGGTCCAAATATTTTGGACCCTATGGCAGTGCTT
TTGCTGTCAGAGAGACGATAAAACTTGTGAGGAAGATGTTTCCTATAAGGACCTGCAATGTAAATATAGAAAAAAGCCTG
GGAAAAGTGAGAGAATGCCTTTATTACCACATAGGGCTTTGTTCTGCGCCCTGCACAGGGAGAATAGAGAAAGAGGAGTA
CAGAAAATTGGTAGATCAGGCAGTCATGTTTTTAGAAGGGAAAAGAGAATGGCTTGTTGAGAAATTAAAGGAAGAAATGC
AGAAGGCTGCCGATGAGCTTAGGTTTGAAGAAGCAGCAAGGTTAAGAGACCAGATTTTTGCCATAGAGAAAATTTCAGAG
AAGCAAAAGGTAACCTCTATCAATGAAGATGAACAGGATGTAATTTCAATGGCGAGAAGTGACGATATCGCGCACATAGA
GGTGTTTTTTGTGAGGGAAGGGAAATTGAGCGGGAGAGAACATTACTACATGAAAAATACAGAGGGAATGGGAAGAGAAG
AGATAATCTCTTCTTTTATAAAGCAGTTTTATGAAAGTTCTCCTTCTGTGCCAAAAGAAATAATAATCGATGTGGAGCTA
GAGGAAAAGGACCTTCTAGAGGACTGGCTTTCACAGAAGAGGGGAAACAGGGTGAGCATTACAGTACCTTTAAGAGGAAA
GAAGAAAGAGCTTGTAGACATGGTGTATCAAAATGCAGTAGAGGCTCTAAAAAACGAGATCTTGGCGAGAGAGAAGATTT
TAAAAGACCCGGCTGTATTAGAGCTTTCAAACCTTTTAGGGATTGAATACCCTAAGAGGATAGAAGCCTATGATATATCC
AATGTGAGAGGAGAAGACAATGTAGGTTCTATGGTGGTTTTTGTAGATGGAAAGCCTAAAAAGAGCGAGTACAGGAAGTT
TACTATCAAGTACGTGGAAGGGCAGGATGACTATCAGAGCATGAGGGAGATGATTGAAAGAAGGTTCCTGCATGCACTGG
AAGAGAAAAAACAAATAGAGGAAGGTACCCTTTCTAAAGAAAAAGCCAAGTTTATAGAAATGCCCGACCTCATACTGGTA
GATGGAGGAATTGGCCATGTAAATGCGGCTTTGGAGGTAATAGAAAAGCTAGGAATTTCGGTACCCGTGTATGGAATGGT
AAAGGATTCAAGGCACAGGACGAGAGGGCTTGTGGGGGTTTCTGGGGAAGTTCAGATGCCCGTGACTGGAAGAGCCTTTA
GGCTGGTAGCACAGATACAGGAAGAAGCACACCGGTTTGCTATAACTTTTCACAGAGAAAGGCAGAGCAAAAGATTTAAG
ACAGATCTTTTAAACATCAAAGGGATTGGAGAAAAGAGGGCAAAAGTCCTCTATGAAGCTTTTGGCTCAATTGAGGAGAT
AAAAAAGGCCTCTTTAGAGGAACTTAAAAAAGTTAAGGGAATGAATGAGAGGTCAGCAAAAGCAGTTTATGAATATTTTC
ACGGCGAAGTTTAA

Upstream 100 bases:

>100_bases
TAGCTGTAGCTGTGGTTGTTGAAAATGGCGGGGAAGGTGGAAAAGTAGCAGCACCTATTGCAAGAGACATAATAAAGGCT
TATCTTTCGAGGTGAGAGAG

Downstream 100 bases:

>100_bases
ATGTAGTCCAAAAGTCCTCTTACAGAGACTTCCCCTGATAGGAGGGCTATTTCTTCACCTTTTTCTGTCTTTATTACTAG
TTTTCCCTCTTTATCTATTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MDLQEKLKLLPEKPGVYLMKDEEGNIIYVGKASVLKNRVRQYFQNTDNHPPKVKVMLSHVEDFEYIVTDTELEALMLECN
LIKKYKPKYNVLLKDDKNYPYIKITVAEDYPRIMFTRKIDMDGSKYFGPYGSAFAVRETIKLVRKMFPIRTCNVNIEKSL
GKVRECLYYHIGLCSAPCTGRIEKEEYRKLVDQAVMFLEGKREWLVEKLKEEMQKAADELRFEEAARLRDQIFAIEKISE
KQKVTSINEDEQDVISMARSDDIAHIEVFFVREGKLSGREHYYMKNTEGMGREEIISSFIKQFYESSPSVPKEIIIDVEL
EEKDLLEDWLSQKRGNRVSITVPLRGKKKELVDMVYQNAVEALKNEILAREKILKDPAVLELSNLLGIEYPKRIEAYDIS
NVRGEDNVGSMVVFVDGKPKKSEYRKFTIKYVEGQDDYQSMREMIERRFLHALEEKKQIEEGTLSKEKAKFIEMPDLILV
DGGIGHVNAALEVIEKLGISVPVYGMVKDSRHRTRGLVGVSGEVQMPVTGRAFRLVAQIQEEAHRFAITFHRERQSKRFK
TDLLNIKGIGEKRAKVLYEAFGSIEEIKKASLEELKKVKGMNERSAKAVYEYFHGEV

Sequences:

>Translated_617_residues
MDLQEKLKLLPEKPGVYLMKDEEGNIIYVGKASVLKNRVRQYFQNTDNHPPKVKVMLSHVEDFEYIVTDTELEALMLECN
LIKKYKPKYNVLLKDDKNYPYIKITVAEDYPRIMFTRKIDMDGSKYFGPYGSAFAVRETIKLVRKMFPIRTCNVNIEKSL
GKVRECLYYHIGLCSAPCTGRIEKEEYRKLVDQAVMFLEGKREWLVEKLKEEMQKAADELRFEEAARLRDQIFAIEKISE
KQKVTSINEDEQDVISMARSDDIAHIEVFFVREGKLSGREHYYMKNTEGMGREEIISSFIKQFYESSPSVPKEIIIDVEL
EEKDLLEDWLSQKRGNRVSITVPLRGKKKELVDMVYQNAVEALKNEILAREKILKDPAVLELSNLLGIEYPKRIEAYDIS
NVRGEDNVGSMVVFVDGKPKKSEYRKFTIKYVEGQDDYQSMREMIERRFLHALEEKKQIEEGTLSKEKAKFIEMPDLILV
DGGIGHVNAALEVIEKLGISVPVYGMVKDSRHRTRGLVGVSGEVQMPVTGRAFRLVAQIQEEAHRFAITFHRERQSKRFK
TDLLNIKGIGEKRAKVLYEAFGSIEEIKKASLEELKKVKGMNERSAKAVYEYFHGEV
>Mature_617_residues
MDLQEKLKLLPEKPGVYLMKDEEGNIIYVGKASVLKNRVRQYFQNTDNHPPKVKVMLSHVEDFEYIVTDTELEALMLECN
LIKKYKPKYNVLLKDDKNYPYIKITVAEDYPRIMFTRKIDMDGSKYFGPYGSAFAVRETIKLVRKMFPIRTCNVNIEKSL
GKVRECLYYHIGLCSAPCTGRIEKEEYRKLVDQAVMFLEGKREWLVEKLKEEMQKAADELRFEEAARLRDQIFAIEKISE
KQKVTSINEDEQDVISMARSDDIAHIEVFFVREGKLSGREHYYMKNTEGMGREEIISSFIKQFYESSPSVPKEIIIDVEL
EEKDLLEDWLSQKRGNRVSITVPLRGKKKELVDMVYQNAVEALKNEILAREKILKDPAVLELSNLLGIEYPKRIEAYDIS
NVRGEDNVGSMVVFVDGKPKKSEYRKFTIKYVEGQDDYQSMREMIERRFLHALEEKKQIEEGTLSKEKAKFIEMPDLILV
DGGIGHVNAALEVIEKLGISVPVYGMVKDSRHRTRGLVGVSGEVQMPVTGRAFRLVAQIQEEAHRFAITFHRERQSKRFK
TDLLNIKGIGEKRAKVLYEAFGSIEEIKKASLEELKKVKGMNERSAKAVYEYFHGEV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=624, Percent_Identity=34.4551282051282, Blast_Score=376, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_THETN (Q8R8M9)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623541.1
- ProteinModelPortal:   Q8R8M9
- GeneID:   997162
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1966
- NMPDR:   fig|273068.3.peg.1936
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   TTEN273068:TTE1966-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71488; Mature: 71488

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQEKLKLLPEKPGVYLMKDEEGNIIYVGKASVLKNRVRQYFQNTDNHPPKVKVMLSHV
CCHHHHHHHCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCCCCEEHHHHHH
EDFEYIVTDTELEALMLECNLIKKYKPKYNVLLKDDKNYPYIKITVAEDYPRIMFTRKID
CCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEEEC
MDGSKYFGPYGSAFAVRETIKLVRKMFPIRTCNVNIEKSLGKVRECLYYHIGLCSAPCTG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
RIEKEEYRKLVDQAVMFLEGKREWLVEKLKEEMQKAADELRFEEAARLRDQIFAIEKISE
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQKVTSINEDEQDVISMARSDDIAHIEVFFVREGKLSGREHYYMKNTEGMGREEIISSFI
HHHHCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHH
KQFYESSPSVPKEIIIDVELEEKDLLEDWLSQKRGNRVSITVPLRGKKKELVDMVYQNAV
HHHHHCCCCCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALKNEILAREKILKDPAVLELSNLLGIEYPKRIEAYDISNVRGEDNVGSMVVFVDGKPK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCC
KSEYRKFTIKYVEGQDDYQSMREMIERRFLHALEEKKQIEEGTLSKEKAKFIEMPDLILV
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEE
DGGIGHVNAALEVIEKLGISVPVYGMVKDSRHRTRGLVGVSGEVQMPVTGRAFRLVAQIQ
ECCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCEEECCCCEECCCCCHHHHHHHHHH
EEAHRFAITFHRERQSKRFKTDLLNIKGIGEKRAKVLYEAFGSIEEIKKASLEELKKVKG
HHHHHEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
MNERSAKAVYEYFHGEV
CCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLQEKLKLLPEKPGVYLMKDEEGNIIYVGKASVLKNRVRQYFQNTDNHPPKVKVMLSHV
CCHHHHHHHCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCCCCEEHHHHHH
EDFEYIVTDTELEALMLECNLIKKYKPKYNVLLKDDKNYPYIKITVAEDYPRIMFTRKID
CCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEEEC
MDGSKYFGPYGSAFAVRETIKLVRKMFPIRTCNVNIEKSLGKVRECLYYHIGLCSAPCTG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
RIEKEEYRKLVDQAVMFLEGKREWLVEKLKEEMQKAADELRFEEAARLRDQIFAIEKISE
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQKVTSINEDEQDVISMARSDDIAHIEVFFVREGKLSGREHYYMKNTEGMGREEIISSFI
HHHHCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHH
KQFYESSPSVPKEIIIDVELEEKDLLEDWLSQKRGNRVSITVPLRGKKKELVDMVYQNAV
HHHHHCCCCCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALKNEILAREKILKDPAVLELSNLLGIEYPKRIEAYDISNVRGEDNVGSMVVFVDGKPK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCC
KSEYRKFTIKYVEGQDDYQSMREMIERRFLHALEEKKQIEEGTLSKEKAKFIEMPDLILV
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEE
DGGIGHVNAALEVIEKLGISVPVYGMVKDSRHRTRGLVGVSGEVQMPVTGRAFRLVAQIQ
ECCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCEEECCCCEECCCCCHHHHHHHHHH
EEAHRFAITFHRERQSKRFKTDLLNIKGIGEKRAKVLYEAFGSIEEIKKASLEELKKVKG
HHHHHEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
MNERSAKAVYEYFHGEV
CCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336