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The map label for this gene is PheA [H]

Identifier: 20807492

GI number: 20807492

Start: 1014538

End: 1015389

Strand: Direct

Name: PheA [H]

Synonym: TTE1012

Alternate gene names: 20807492

Gene position: 1014538-1015389 (Clockwise)

Preceding gene: 20807491

Following gene: 20807493

Centisome position: 37.72

GC content: 38.5

Gene sequence:

>852_bases
ATGATAAGGGGGTGTAGGATGAAAGTTGGGTATTTAGGGCCTAAAGGTACTTTTTCTGAAGAGGCTGTTTTTAAATATAT
AGAAGGAATGAAAGAGTGTGAAGCTATAGAGTTTGCTACCATCCAAGATGTAGTTAAAAGTGTAGCGGAAGGGACGTGCG
ATGAGGGCATTTTGCCTGTTGAAAATTCTATTGAGGGTTCTGTCAATGTATCACTGGATTTGTTGATAAACGATGCCGAG
GGTATTTTGGTCAGAGGAGAGGTGATAATTTCTATTTCACAATGTTTGATTTGCGATGACTTTATTGACTTTAAAGATGT
ACATTGTATACTTTCTCATCCTCAGGCTCTTGCCCAGTGCAGGGAATACATATTGAATAATTTCCCAACGGCTGAAGTAA
AAACTACAGAAAGCACTGTAAAGGCTTTGTTAGGGGTAAATGCTAAAAAAGGGATAGTTGCTATTGGGCCGGAAAGAGCT
GCTTGGCTTTACAACCTTAAGATATTAGAAAAAGATGTGCAGGATATAAAGGAGAATTACACAAGGTTTCTGGTTATTGC
GAAAAGAGACAGTGACTATACAGGGGAGGACAAGACTTCAATAGTTTTTTCTGTGCCGAATGTTCCTGGAAGTTTGTATA
GGGCTTTAGGAGTGTTTGCAGAAAAGAATATCAATATGACAAAAATTGAGTCAAGGCCTTCTCGCAAAAAGTTTGGGGAG
TACGTCTTTTGGGTAGATATAGAAGGCCACAGAAAAGAGGAGAGGATAAAAGAGGCTTTGGAAGATCTGAAGATAAAGGC
AGATTTTTTGAAAGTGATAGGTTCTTATCCAAAGTTCAAGATGGGAAAATAA

Upstream 100 bases:

>100_bases
TAAGGCGGGTACACCGCTTTTTTTATTATCCTTTTATAAGGTTTATGAAAAATTTACTTGACTTTAATTAGGCAAAGTAT
TAAAATATCAGCAATATAGT

Downstream 100 bases:

>100_bases
AGGGAGGAGAAGAGGTATGGTAATTGTAATGAATATAGATGCTAGTGAGAAACAAATTTCCGAGATTACAAATCTTTTAA
CTTCTCTCGGGCTGGGTTAT

Product: prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MIRGCRMKVGYLGPKGTFSEEAVFKYIEGMKECEAIEFATIQDVVKSVAEGTCDEGILPVENSIEGSVNVSLDLLINDAE
GILVRGEVIISISQCLICDDFIDFKDVHCILSHPQALAQCREYILNNFPTAEVKTTESTVKALLGVNAKKGIVAIGPERA
AWLYNLKILEKDVQDIKENYTRFLVIAKRDSDYTGEDKTSIVFSVPNVPGSLYRALGVFAEKNINMTKIESRPSRKKFGE
YVFWVDIEGHRKEERIKEALEDLKIKADFLKVIGSYPKFKMGK

Sequences:

>Translated_283_residues
MIRGCRMKVGYLGPKGTFSEEAVFKYIEGMKECEAIEFATIQDVVKSVAEGTCDEGILPVENSIEGSVNVSLDLLINDAE
GILVRGEVIISISQCLICDDFIDFKDVHCILSHPQALAQCREYILNNFPTAEVKTTESTVKALLGVNAKKGIVAIGPERA
AWLYNLKILEKDVQDIKENYTRFLVIAKRDSDYTGEDKTSIVFSVPNVPGSLYRALGVFAEKNINMTKIESRPSRKKFGE
YVFWVDIEGHRKEERIKEALEDLKIKADFLKVIGSYPKFKMGK
>Mature_283_residues
MIRGCRMKVGYLGPKGTFSEEAVFKYIEGMKECEAIEFATIQDVVKSVAEGTCDEGILPVENSIEGSVNVSLDLLINDAE
GILVRGEVIISISQCLICDDFIDFKDVHCILSHPQALAQCREYILNNFPTAEVKTTESTVKALLGVNAKKGIVAIGPERA
AWLYNLKILEKDVQDIKENYTRFLVIAKRDSDYTGEDKTSIVFSVPNVPGSLYRALGVFAEKNINMTKIESRPSRKKFGE
YVFWVDIEGHRKEERIKEALEDLKIKADFLKVIGSYPKFKMGK

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=278, Percent_Identity=31.294964028777, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324013, Length=323, Percent_Identity=27.2445820433437, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 31731; Mature: 31731

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGCRMKVGYLGPKGTFSEEAVFKYIEGMKECEAIEFATIQDVVKSVAEGTCDEGILPV
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ENSIEGSVNVSLDLLINDAEGILVRGEVIISISQCLICDDFIDFKDVHCILSHPQALAQC
CCCCCCCEEEEEEEEEECCCCEEEECCEEEEEHHHHHHHCCCCHHHHHHHHCCHHHHHHH
REYILNNFPTAEVKTTESTVKALLGVNAKKGIVAIGPERAAWLYNLKILEKDVQDIKENY
HHHHHCCCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHCC
TRFLVIAKRDSDYTGEDKTSIVFSVPNVPGSLYRALGVFAEKNINMTKIESRPSRKKFGE
EEEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCC
YVFWVDIEGHRKEERIKEALEDLKIKADFLKVIGSYPKFKMGK
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIRGCRMKVGYLGPKGTFSEEAVFKYIEGMKECEAIEFATIQDVVKSVAEGTCDEGILPV
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ENSIEGSVNVSLDLLINDAEGILVRGEVIISISQCLICDDFIDFKDVHCILSHPQALAQC
CCCCCCCEEEEEEEEEECCCCEEEECCEEEEEHHHHHHHCCCCHHHHHHHHCCHHHHHHH
REYILNNFPTAEVKTTESTVKALLGVNAKKGIVAIGPERAAWLYNLKILEKDVQDIKENY
HHHHHCCCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHCC
TRFLVIAKRDSDYTGEDKTSIVFSVPNVPGSLYRALGVFAEKNINMTKIESRPSRKKFGE
EEEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCC
YVFWVDIEGHRKEERIKEALEDLKIKADFLKVIGSYPKFKMGK
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]