Click here to switch to the map view.

The map label for this gene is aroB

Identifier: 20807491

GI number: 20807491

Start: 1013370

End: 1014440

Strand: Direct

Name: aroB

Synonym: TTE1011

Alternate gene names: 20807491

Gene position: 1013370-1014440 (Clockwise)

Preceding gene: 20807490

Following gene: 20807492

Centisome position: 37.68

GC content: 35.01

Gene sequence:

>1071_bases
ATGGATGAAGTGATTGTTGAATTGAAGGAAAGGTCTTATCCTATTTATTTTGACTATGAAGGTTTTGATAGAGTTGGAGA
TTTAATTAAAAAACATGTGAGAAGCAGCAAGACATTTGTTATTACTGATTCTAATGTTTATCCTTTGTATTTTGAAAAGA
TTGAAGAAAGCCTTAGAAAAAGTGGATTCGATGTCTTATATGAAGTTATACCTGCTGGTGAGACGAGCAAAACTATGGAA
ATGGCACAAAGACTTCTTGAGGTAGCTTATGACAGTGGTCTTTTAAGGGATAGTTCTATCATTGCACTGGGGGGAGGAGT
TGTTGGAGATATAGCCGGGTTTGTTGCTGCGACCTATATGAGAGGAATTGATTTTATTCAGATTCCTACGACATTGTTAG
CTCAGGTAGACAGCAGTGTTGGTGGTAAGGTAGCGGTAAATCTAAAAAAAGGTAAGAATATAGTTGGAGCTTTTTATCAA
CCTAAAATGGTGTATATTGATACTTCAGTTTTGGGGACTTTGAATAAAAGAGAAGTTCTTGGTGGATTAGCTGAAGTAAT
CAAGTATGGAGTTATATGGGACTTTGATTTGTTTACCTATATTGAAGAAAATTTGGGTGATATTTTGAGATTAAAAAAGG
AGGATTTGACTTATATAGTTAAAAGGTCATGTGAGATAAAAGCTAAGGTTGTATCATTGGATGAAAAAGAAGAGAATTTA
AGAGCGATATTAAATTTTGGGCATACAATAGGTCATGCTATTGAGGCTTTAACAGGGTATGAGAGATATATTCACGGAGA
AGCTGTGGCAATAGGAATGGCGTATGAGGCACGGCTTGCATTTAACTTGGGATATATTGATGAAGGATATTTAGAGCGCA
TATTGAATTTAATTAAAAGAGCGGGACTGCCAGCTGACTATGAGGGTATTGAAAAGACGGATATGCTAAATGCCATAAAG
CTTGATAAAAAAATGAGAGAAGGGAGAATAAATTTTGTTCTACCTGTAGGTTTAGGCAAAGTGGATATTGTGAGTGTGAA
AGAAGAAGATGTATTAAAAGTTTTGAAATAA

Upstream 100 bases:

>100_bases
ATGTTTTTGAAAAATTACTTGATGAGTTTGAAAAGATGGCATGAGACAAGGGGGACAAAAGGAACCGTCCCCTTTGTCTG
GTGTAAAAAGAGGTGGGAGT

Downstream 100 bases:

>100_bases
GGCGGGTACACCGCTTTTTTTATTATCCTTTTATAAGGTTTATGAAAAATTTACTTGACTTTAATTAGGCAAAGTATTAA
AATATCAGCAATATAGTATG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDEVIVELKERSYPIYFDYEGFDRVGDLIKKHVRSSKTFVITDSNVYPLYFEKIEESLRKSGFDVLYEVIPAGETSKTME
MAQRLLEVAYDSGLLRDSSIIALGGGVVGDIAGFVAATYMRGIDFIQIPTTLLAQVDSSVGGKVAVNLKKGKNIVGAFYQ
PKMVYIDTSVLGTLNKREVLGGLAEVIKYGVIWDFDLFTYIEENLGDILRLKKEDLTYIVKRSCEIKAKVVSLDEKEENL
RAILNFGHTIGHAIEALTGYERYIHGEAVAIGMAYEARLAFNLGYIDEGYLERILNLIKRAGLPADYEGIEKTDMLNAIK
LDKKMREGRINFVLPVGLGKVDIVSVKEEDVLKVLK

Sequences:

>Translated_356_residues
MDEVIVELKERSYPIYFDYEGFDRVGDLIKKHVRSSKTFVITDSNVYPLYFEKIEESLRKSGFDVLYEVIPAGETSKTME
MAQRLLEVAYDSGLLRDSSIIALGGGVVGDIAGFVAATYMRGIDFIQIPTTLLAQVDSSVGGKVAVNLKKGKNIVGAFYQ
PKMVYIDTSVLGTLNKREVLGGLAEVIKYGVIWDFDLFTYIEENLGDILRLKKEDLTYIVKRSCEIKAKVVSLDEKEENL
RAILNFGHTIGHAIEALTGYERYIHGEAVAIGMAYEARLAFNLGYIDEGYLERILNLIKRAGLPADYEGIEKTDMLNAIK
LDKKMREGRINFVLPVGLGKVDIVSVKEEDVLKVLK
>Mature_356_residues
MDEVIVELKERSYPIYFDYEGFDRVGDLIKKHVRSSKTFVITDSNVYPLYFEKIEESLRKSGFDVLYEVIPAGETSKTME
MAQRLLEVAYDSGLLRDSSIIALGGGVVGDIAGFVAATYMRGIDFIQIPTTLLAQVDSSVGGKVAVNLKKGKNIVGAFYQ
PKMVYIDTSVLGTLNKREVLGGLAEVIKYGVIWDFDLFTYIEENLGDILRLKKEDLTYIVKRSCEIKAKVVSLDEKEENL
RAILNFGHTIGHAIEALTGYERYIHGEAVAIGMAYEARLAFNLGYIDEGYLERILNLIKRAGLPADYEGIEKTDMLNAIK
LDKKMREGRINFVLPVGLGKVDIVSVKEEDVLKVLK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=357, Percent_Identity=43.9775910364146, Blast_Score=290, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6320332, Length=321, Percent_Identity=39.8753894080997, Blast_Score=219, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_THETN (Q8RB14)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622662.1
- ProteinModelPortal:   Q8RB14
- SMR:   Q8RB14
- GeneID:   995777
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1011
- NMPDR:   fig|273068.3.peg.476
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   TTEN273068:TTE1011-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39851; Mature: 39851

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEVIVELKERSYPIYFDYEGFDRVGDLIKKHVRSSKTFVITDSNVYPLYFEKIEESLRK
CCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
SGFDVLYEVIPAGETSKTMEMAQRLLEVAYDSGLLRDSSIIALGGGVVGDIAGFVAATYM
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
RGIDFIQIPTTLLAQVDSSVGGKVAVNLKKGKNIVGAFYQPKMVYIDTSVLGTLNKREVL
HCCCEEEHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEEEEHHHHHCCCHHHHH
GGLAEVIKYGVIWDFDLFTYIEENLGDILRLKKEDLTYIVKRSCEIKAKVVSLDEKEENL
HHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHH
RAILNFGHTIGHAIEALTGYERYIHGEAVAIGMAYEARLAFNLGYIDEGYLERILNLIKR
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHH
AGLPADYEGIEKTDMLNAIKLDKKMREGRINFVLPVGLGKVDIVSVKEEDVLKVLK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHCC
>Mature Secondary Structure
MDEVIVELKERSYPIYFDYEGFDRVGDLIKKHVRSSKTFVITDSNVYPLYFEKIEESLRK
CCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
SGFDVLYEVIPAGETSKTMEMAQRLLEVAYDSGLLRDSSIIALGGGVVGDIAGFVAATYM
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
RGIDFIQIPTTLLAQVDSSVGGKVAVNLKKGKNIVGAFYQPKMVYIDTSVLGTLNKREVL
HCCCEEEHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEEEEHHHHHCCCHHHHH
GGLAEVIKYGVIWDFDLFTYIEENLGDILRLKKEDLTYIVKRSCEIKAKVVSLDEKEENL
HHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHH
RAILNFGHTIGHAIEALTGYERYIHGEAVAIGMAYEARLAFNLGYIDEGYLERILNLIKR
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHH
AGLPADYEGIEKTDMLNAIKLDKKMREGRINFVLPVGLGKVDIVSVKEEDVLKVLK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336