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The map label for this gene is coaE

Identifier: 20807356

GI number: 20807356

Start: 885314

End: 885919

Strand: Direct

Name: coaE

Synonym: TTE0875

Alternate gene names: 20807356

Gene position: 885314-885919 (Clockwise)

Preceding gene: 20807355

Following gene: 20807357

Centisome position: 32.92

GC content: 36.14

Gene sequence:

>606_bases
ATGAGAGTAGTTGGGCTCACGGGAGGCATCGGTTCAGGGAAAAGCACGGTGTCTGGAATTTTGGCAAAACTCGGGGCTAA
GATAATAGATGCAGATTTGGTCTCCCGTGAGATAATGGAAAAGGGAAAAGAAGCATATAATGAGATTGTAGATTGCTTTG
GCAAAGAGATTTTAGATAAAGAGGGAAATATAGACAGAAAAAAATTAGGGTCAATTGTGTTTAGCGACAAAGAAAAGCTC
AAAAGATTGAATGAAATCACTCATCCCAAAATAATAGATAAAATAAAGAAAATGATAGAGGAAGAAAAGGATAAAGATAA
AGTGATTGTCATAGATGCAGCCCTTTTAATTGAGACAGGGCTTTACAAACTGGTAGATGAAGTTTGGCTTGTGGTTGTAG
ATATAGACACGCAAATAAAAAGGGTTATGGAAAGAGATGGTTTTTCCTGTGAAGAAGCTTTAAAGAGGATAAAAAGCCAG
ATGCCTTTAGAGGAGAAAATAAAGTACGCGGATTTTATAATAAATAACAGCAAAGATTTGAGGAAAACTGAAGAGCAAGT
ACGACTTTTATGGCAAAGATTTGATCGGAGGAGTTACTTTGATTAA

Upstream 100 bases:

>100_bases
ACTCAAAGAAAACATGGAGAATGTGATAAAGCTGAAAGTTCCGCTGGTTGTTGAAATTGGGGTGGGTCCTAACTGGTTTT
TGGCTAAGTGAGGTGGAAAT

Downstream 100 bases:

>100_bases
GAGATGGGTACTTTTTCTACTAATAATCTTGGCTATTCTTTTGACGTTTGAAATGAATACTCACTATTTTTTGAAGAAAT
TTTATCCTTTAAAGTACGAA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDKEGNIDRKKLGSIVFSDKEKL
KRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETGLYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQ
MPLEEKIKYADFIINNSKDLRKTEEQVRLLWQRFDRRSYFD

Sequences:

>Translated_201_residues
MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDKEGNIDRKKLGSIVFSDKEKL
KRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETGLYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQ
MPLEEKIKYADFIINNSKDLRKTEEQVRLLWQRFDRRSYFD
>Mature_201_residues
MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDKEGNIDRKKLGSIVFSDKEKL
KRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETGLYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQ
MPLEEKIKYADFIINNSKDLRKTEEQVRLLWQRFDRRSYFD

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=198, Percent_Identity=36.8686868686869, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI191252795, Length=198, Percent_Identity=36.8686868686869, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI205277394, Length=202, Percent_Identity=38.1188118811881, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI110227605, Length=202, Percent_Identity=38.1188118811881, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI110227603, Length=202, Percent_Identity=38.1188118811881, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI110227601, Length=202, Percent_Identity=38.1188118811881, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI110227607, Length=202, Percent_Identity=38.1188118811881, Blast_Score=134, Evalue=4e-32,
Organism=Escherichia coli, GI1786292, Length=175, Percent_Identity=36, Blast_Score=118, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17554944, Length=199, Percent_Identity=38.6934673366834, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25143409, Length=186, Percent_Identity=34.4086021505376, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320402, Length=193, Percent_Identity=39.8963730569948, Blast_Score=114, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24658602, Length=193, Percent_Identity=36.7875647668394, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24644728, Length=186, Percent_Identity=38.7096774193548, Blast_Score=129, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_THETN (Q8RBE5)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622527.1
- ProteinModelPortal:   Q8RBE5
- SMR:   Q8RBE5
- GeneID:   996016
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0875
- NMPDR:   fig|273068.3.peg.1249
- HOGENOM:   HBG650290
- OMA:   VVVYCDP
- ProtClustDB:   PRK00081
- BioCyc:   TTEN273068:TTE0875-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23106; Mature: 23106

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDK
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EGNIDRKKLGSIVFSDKEKLKRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETG
CCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
LYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQMPLEEKIKYADFIINNSKDL
HHHHHHHHHHHEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHH
RKTEEQVRLLWQRFDRRSYFD
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDK
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EGNIDRKKLGSIVFSDKEKLKRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETG
CCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
LYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQMPLEEKIKYADFIINNSKDL
HHHHHHHHHHHEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHH
RKTEEQVRLLWQRFDRRSYFD
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336