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The map label for this gene is PurM

Identifier: 20807085

GI number: 20807085

Start: 591509

End: 592519

Strand: Direct

Name: PurM

Synonym: TTE0590

Alternate gene names: 20807085

Gene position: 591509-592519 (Clockwise)

Preceding gene: 161760535

Following gene: 20807086

Centisome position: 21.99

GC content: 37.69

Gene sequence:

>1011_bases
ATGAAATATAAAGACGCAGGGGTAAATATAGATGAGGGAAACAAGTTTGTAAAGATGATAAAGCCTTTTGCAGAAAAGAC
AATAAAAGAAGGTGTTTTAGAGGGAATTGGGGGGTTTGCAGCTCTTTACGAGATAAAGAATTATAAAAATCCAGTGCTTG
TGTCTAGTACAGATGGAGTTGGAACGAAACTTAAAATAGCCTTTATGATGGATAAGCACGATACTGTAGGGATAGACTTG
GTGGCTATGTGTGTAAATGACGTGATTGTAGTGGGAGCAAAGCCCCTCTTTTTTCTAGATTATTTTGCTACTGGAAAGTT
AGAAAGCGAAAAAGCGATACAGGTCATTAAAGGAGTAGCAGAAGGGTGTGAAATTGCTGGGTGTGCTTTAATTGGAGGTG
AAACTGCTGAACTTCCTGGTTTTTATAAAGAAGGGGAGTATGACCTAGCAGGGTTTTGCGTGGGGATAGTGGAAAAAGAA
GAAATAATTGACACTTCTTCTATGGCGATTGGAGATGTAGTAATAGGGCTTTCTTCCTCTGGACTTCACAGCAATGGCTA
TTCTCTTGTGAGAAAAGTATTTTTTGAAAAAAACAATTTTTCTATAGAAGATTACGTGCCAGATATAGGCAAAACCTTAG
GAGAAGTTCTTTTGACACCCACTAAAATATATGTAAAATCTGTGGAAGTTTTGAAAGGATTAAAAATAAAAGGAATGGCT
CATATAACAGGAGGGGGCTTTATTGAAAATATTCCTAGAATTTTGAGAAAAGGCGTTTCTGCAAGAATATACAAAGGGAG
CTGGGAAGTGCCGATTATCTTTGACATGATAAGAAGGCTTGGAGAAATAGAAGAGAAAGAGATGTACAGGACTTTCAATA
TGGGTATTGGAATGGTAGTCATAATTGATAAAGAAGAAGTGGAGAAAGCTCTAAAAAGGCTTAAAGAAGTGGGAGAGACA
GCTTTTGTGATTGGAGAGATTGTGGAGGGAGAAGGCGGTGTGATTTTATGA

Upstream 100 bases:

>100_bases
CTGAAAAGTTGAAGGGTTTAAAAAGTGGGAATTTCACTTATGTGTGCGGTGCCTTAGCGAAAATTATCTTTTGGAAAATT
AAAATAGCGGGTGTATAATT

Downstream 100 bases:

>100_bases
GGCTTGTGGTAATGGCATCGGGTAATGGCACAGATCTGCAGTCAATAATCGATGCCATTGAAGCTGGTTATATAAAAGCT
CAGATAATCGGAGTGGTGAG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKYKDAGVNIDEGNKFVKMIKPFAEKTIKEGVLEGIGGFAALYEIKNYKNPVLVSSTDGVGTKLKIAFMMDKHDTVGIDL
VAMCVNDVIVVGAKPLFFLDYFATGKLESEKAIQVIKGVAEGCEIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKE
EIIDTSSMAIGDVVIGLSSSGLHSNGYSLVRKVFFEKNNFSIEDYVPDIGKTLGEVLLTPTKIYVKSVEVLKGLKIKGMA
HITGGGFIENIPRILRKGVSARIYKGSWEVPIIFDMIRRLGEIEEKEMYRTFNMGIGMVVIIDKEEVEKALKRLKEVGET
AFVIGEIVEGEGGVIL

Sequences:

>Translated_336_residues
MKYKDAGVNIDEGNKFVKMIKPFAEKTIKEGVLEGIGGFAALYEIKNYKNPVLVSSTDGVGTKLKIAFMMDKHDTVGIDL
VAMCVNDVIVVGAKPLFFLDYFATGKLESEKAIQVIKGVAEGCEIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKE
EIIDTSSMAIGDVVIGLSSSGLHSNGYSLVRKVFFEKNNFSIEDYVPDIGKTLGEVLLTPTKIYVKSVEVLKGLKIKGMA
HITGGGFIENIPRILRKGVSARIYKGSWEVPIIFDMIRRLGEIEEKEMYRTFNMGIGMVVIIDKEEVEKALKRLKEVGET
AFVIGEIVEGEGGVIL
>Mature_336_residues
MKYKDAGVNIDEGNKFVKMIKPFAEKTIKEGVLEGIGGFAALYEIKNYKNPVLVSSTDGVGTKLKIAFMMDKHDTVGIDL
VAMCVNDVIVVGAKPLFFLDYFATGKLESEKAIQVIKGVAEGCEIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKE
EIIDTSSMAIGDVVIGLSSSGLHSNGYSLVRKVFFEKNNFSIEDYVPDIGKTLGEVLLTPTKIYVKSVEVLKGLKIKGMA
HITGGGFIENIPRILRKGVSARIYKGSWEVPIIFDMIRRLGEIEEKEMYRTFNMGIGMVVIIDKEEVEKALKRLKEVGET
AFVIGEIVEGEGGVIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=48.502994011976, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=48.502994011976, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=48.502994011976, Blast_Score=319, Evalue=2e-87,
Organism=Escherichia coli, GI1788845, Length=327, Percent_Identity=54.434250764526, Blast_Score=353, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=45.0292397660819, Blast_Score=256, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=46.3126843657817, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=46.1538461538462, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_THETN (Q8RC57)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622256.1
- ProteinModelPortal:   Q8RC57
- SMR:   Q8RC57
- GeneID:   996577
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0590
- NMPDR:   fig|273068.3.peg.67
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   TTEN273068:TTE0590-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36646; Mature: 36646

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYKDAGVNIDEGNKFVKMIKPFAEKTIKEGVLEGIGGFAALYEIKNYKNPVLVSSTDGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
GTKLKIAFMMDKHDTVGIDLVAMCVNDVIVVGAKPLFFLDYFATGKLESEKAIQVIKGVA
CCEEEEEEEECCCCCCCHHHHHHHHHCEEEECCCHHEEEEHHHCCCCCHHHHHHHHHHHH
EGCEIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKEEIIDTSSMAIGDVVIGLSSS
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHEEEEECHHHHHCCCCHHHHHEEEECCCC
GLHSNGYSLVRKVFFEKNNFSIEDYVPDIGKTLGEVLLTPTKIYVKSVEVLKGLKIKGMA
CCCCCHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCEE
HITGGGFIENIPRILRKGVSARIYKGSWEVPIIFDMIRRLGEIEEKEMYRTFNMGIGMVV
EECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEE
IIDKEEVEKALKRLKEVGETAFVIGEIVEGEGGVIL
EECHHHHHHHHHHHHHHCCCEEEEHEEEECCCCEEC
>Mature Secondary Structure
MKYKDAGVNIDEGNKFVKMIKPFAEKTIKEGVLEGIGGFAALYEIKNYKNPVLVSSTDGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
GTKLKIAFMMDKHDTVGIDLVAMCVNDVIVVGAKPLFFLDYFATGKLESEKAIQVIKGVA
CCEEEEEEEECCCCCCCHHHHHHHHHCEEEECCCHHEEEEHHHCCCCCHHHHHHHHHHHH
EGCEIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKEEIIDTSSMAIGDVVIGLSSS
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHEEEEECHHHHHCCCCHHHHHEEEECCCC
GLHSNGYSLVRKVFFEKNNFSIEDYVPDIGKTLGEVLLTPTKIYVKSVEVLKGLKIKGMA
CCCCCHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCEE
HITGGGFIENIPRILRKGVSARIYKGSWEVPIIFDMIRRLGEIEEKEMYRTFNMGIGMVV
EECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEE
IIDKEEVEKALKRLKEVGETAFVIGEIVEGEGGVIL
EECHHHHHHHHHHHHHHCCCEEEEHEEEECCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336