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The map label for this gene is PurC

Identifier: 161760535

GI number: 161760535

Start: 590700

End: 591407

Strand: Direct

Name: PurC

Synonym: TTE0588

Alternate gene names: 161760535

Gene position: 590700-591407 (Clockwise)

Preceding gene: 20807083

Following gene: 20807085

Centisome position: 21.96

GC content: 34.46

Gene sequence:

>708_bases
ATGGAAAAGAAAGAATTGCTTTATGAGGGTAAAGCTAAAAAAGTTTATAAGACGGATAAAGAAGATTACTACATCATAGA
GTACAAAGACGATGCCACTGCTTTTAATGGATTAAAAAAGGGGGTAATTGAAGAAAAAGGAGTCGTCAATAATAAAGTTT
CCTCAATTTTGTTTGAATTTTTAGAAAAAAGAGGGATTCCTACCCACTATGTGAAAATGCTGAAGGACAGAGAGATGCTT
GTCAAAAAAGTTACAATTTTTCCTCTGGAAGTTATCATCAGAAATTATGCCGCAGGTAGTATTTGCAAAAGATTAGGGCT
TCAGGAAGGAATAAAATTTAAGGAGCCCGTTCTAGAATTTTGTTATAAAAACGACGAACTTGGAGACCCTATGATAAACG
AATACCACATCAGGGCTTTAGAACTTGCTACAAGAGATGAAATTGACCTTATAAAAGAGAGAGCTTTTAAGGTGAACGAA
ATTCTGTCAGAGTATTTTCTATCTAAAGATATAATCCTAGTAGATTTTAAGTTAGAATTTGGAAAAAATCAAGAAGGGAT
ATTGTTGGCAGATGAGATTTCGCCAGATACCTGCAGGTTCTGGGATAAAAACACTATGGAAAAACTTGATAAAGACAGGT
TTAGAAAGGACTTAGGTCAAGTAGAAGAAGCATATTTAGAGATTCTGAGAAGGGTCCAGCAGGTTTAA

Upstream 100 bases:

>100_bases
GCCTGCTGGGAATAGGCACTCTCTGAAAAGGCGGACTATAAATAGCCCAGCCTTCTAAACTAGTGCAGTTTTGCACAGTT
TAGATGACCAGGTAAGCTGT

Downstream 100 bases:

>100_bases
ACTGAAAAGTTGAAGGGTTTAAAAAGTGGGAATTTCACTTATGTGTGCGGTGCCTTAGCGAAAATTATCTTTTGGAAAAT
TAAAATAGCGGGTGTATAAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MEKKELLYEGKAKKVYKTDKEDYYIIEYKDDATAFNGLKKGVIEEKGVVNNKVSSILFEFLEKRGIPTHYVKMLKDREML
VKKVTIFPLEVIIRNYAAGSICKRLGLQEGIKFKEPVLEFCYKNDELGDPMINEYHIRALELATRDEIDLIKERAFKVNE
ILSEYFLSKDIILVDFKLEFGKNQEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGQVEEAYLEILRRVQQV

Sequences:

>Translated_235_residues
MEKKELLYEGKAKKVYKTDKEDYYIIEYKDDATAFNGLKKGVIEEKGVVNNKVSSILFEFLEKRGIPTHYVKMLKDREML
VKKVTIFPLEVIIRNYAAGSICKRLGLQEGIKFKEPVLEFCYKNDELGDPMINEYHIRALELATRDEIDLIKERAFKVNE
ILSEYFLSKDIILVDFKLEFGKNQEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGQVEEAYLEILRRVQQV
>Mature_235_residues
MEKKELLYEGKAKKVYKTDKEDYYIIEYKDDATAFNGLKKGVIEEKGVVNNKVSSILFEFLEKRGIPTHYVKMLKDREML
VKKVTIFPLEVIIRNYAAGSICKRLGLQEGIKFKEPVLEFCYKNDELGDPMINEYHIRALELATRDEIDLIKERAFKVNE
ILSEYFLSKDIILVDFKLEFGKNQEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGQVEEAYLEILRRVQQV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=236, Percent_Identity=31.7796610169492, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI5453539, Length=236, Percent_Identity=31.7796610169492, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI119220559, Length=243, Percent_Identity=30.4526748971193, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=43.1034482758621, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17531275, Length=238, Percent_Identity=36.5546218487395, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319326, Length=235, Percent_Identity=28.936170212766, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=31.7991631799163, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24583917, Length=239, Percent_Identity=32.2175732217573, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_THETN (Q8RC58)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622255.2
- ProteinModelPortal:   Q8RC58
- SMR:   Q8RC58
- GeneID:   996621
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0588
- NMPDR:   fig|273068.3.peg.66
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   TTEN273068:TTE0588-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27654; Mature: 27654

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKELLYEGKAKKVYKTDKEDYYIIEYKDDATAFNGLKKGVIEEKGVVNNKVSSILFEF
CCCHHHHHCCCCCHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LEKRGIPTHYVKMLKDREMLVKKVTIFPLEVIIRNYAAGSICKRLGLQEGIKFKEPVLEF
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHH
CYKNDELGDPMINEYHIRALELATRDEIDLIKERAFKVNEILSEYFLSKDIILVDFKLEF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GKNQEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGQVEEAYLEILRRVQQV
CCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKKELLYEGKAKKVYKTDKEDYYIIEYKDDATAFNGLKKGVIEEKGVVNNKVSSILFEF
CCCHHHHHCCCCCHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LEKRGIPTHYVKMLKDREMLVKKVTIFPLEVIIRNYAAGSICKRLGLQEGIKFKEPVLEF
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHH
CYKNDELGDPMINEYHIRALELATRDEIDLIKERAFKVNEILSEYFLSKDIILVDFKLEF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GKNQEGILLADEISPDTCRFWDKNTMEKLDKDRFRKDLGQVEEAYLEILRRVQQV
CCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336