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The map label for this gene is GuaB [H]

Identifier: 20807078

GI number: 20807078

Start: 583275

End: 584729

Strand: Direct

Name: GuaB [H]

Synonym: TTE0582

Alternate gene names: 20807078

Gene position: 583275-584729 (Clockwise)

Preceding gene: 20807076

Following gene: 20807079

Centisome position: 21.69

GC content: 43.64

Gene sequence:

>1455_bases
ATGGAGGATAAGTTTGTAAAGGAAGGTCTGACCTTTGACGATGTGCTTCTAATTCCTGCCAAATCCGACGTTTTGCCTAA
GGATGTGGACCTAAAGACTCGGCTGACAAAGAAGATCACTTTAAACATTCCTTTAATGAGCGCCGGCATGGACACGGTGA
CAGAAGCACGGCTAGCTATAGCTATAGCTAGGGAAGGCGGAATAGGGGTAATTCACAAGAACATGTCCATTGAGAGGCAG
GCAATGGAAGTAGATAAGGTCAAAAGGTCGGAACACGGGGTAATTACAGACCCTTTCTCTCTTTCTCCTGACCACACCAT
AAGAGATGCAGCAGAGTTAATGGCACGGTATAAAATTTCTGGGGTTCCAATCACAGTAGATTCCAAACTGGTAGGAATAA
TCACAAATAGGGATATAAGGTTTGAAGACGATCTAGACAAGCCCATAAGAGAAGTAATGACAAAAGAAAATCTAGTAACA
GCGCCTCCGGGGACGACTTTAGAAGAAGCCAAGCAGATTTTGAAAAAACACAAAATAGAGAAACTGCCTTTAGTAGATGA
GAATAACGTACTAAAAGGGCTTATCACCATCAAAGACATAGAAAAAGCTGTAGAGTTTCCGAACGCAGCAAAGGATGAAA
AAGGAAGGCTTCTGGTAGCCGCAGCTGTTGGTGTCGGGAAAGACATGATGGACAGGGTTAAAGCGCTGATAGAAGCAGGA
GTAGATGCAATTGTGGTAGATACTGCTCATGGCCATTCTACAAGAGTTTTAGATGCTGTAGCAAAAATAAAAGAGAAGTA
CCCAGATGTACAGCTTATTGCAGGAAATGTTGCTACTGCGGAAGCCACTAGAGATTTAATTGAGAGAGGAGCAGACGCCG
TAAAGGTTGGAATTGGACCTGGTTCAATATGCACTACGAGAGTGGTGGCTGGCGTAGGGGTTCCTCAGATAACTGCCATT
TACGAATGCGCTAAAGAAGCCGACAAATACGGTATTCCCGTGATTGCGGATGGAGGAATAAAATATTCAGGGGACATTGT
AAAAGCCATCGCGGCAGGAGCTTCTGTTGTGATGATAGGTAGCTTGTTTGCTGGAACAGAGGAAAGCCCTGGCGAGATAG
AAATATACCAGGGCAGAAGCTATAAGGTCTACCGCGGAATGGGCTCATTAGGGGCTATGAAAGAGGGGAGCTCAGATAGA
TATTTCCAGGAAGAAGCAGTGAAACTGGTGCCAGAAGGAGTAGAGGGAAGGGTACCCTACAGAGGGCCTTTGAGAGAGAC
TGTTTATCAATTAATTGGCGGTCTTAGAGCAGGAATGGGATATTGTGGAGTCAAAAACATTGAGGAGTTGAGGACTAAAA
CTAAATTTGTAAGAATAACACAGGCAGGGTTAATTGAAAGTCACCCTCATGATATAATTATTACGAAAGAAGCTCCTAAT
TATAATTTGAGATAA

Upstream 100 bases:

>100_bases
TCTTACGCTTTGAAGCTATAAATTTTTGAAGCCTTCTAATTATTTAACAAAGACTTTGTCTATGAGGTGTGTTATAATAA
AATGCAAAGGAGATGGAAGT

Downstream 100 bases:

>100_bases
GAGGAGGATTTTGATGGGGATTAAGCGCGAAACCATTTTGATTTTGGACTTTGGTGGCCAGTACACTCAGTTAATTGCCA
GGAGAATAAGAGAAGCTAAT

Product: IMP dehydrogenase/GMP reductase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MEDKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTRLTKKITLNIPLMSAGMDTVTEARLAIAIAREGGIGVIHKNMSIERQ
AMEVDKVKRSEHGVITDPFSLSPDHTIRDAAELMARYKISGVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKENLVT
APPGTTLEEAKQILKKHKIEKLPLVDENNVLKGLITIKDIEKAVEFPNAAKDEKGRLLVAAAVGVGKDMMDRVKALIEAG
VDAIVVDTAHGHSTRVLDAVAKIKEKYPDVQLIAGNVATAEATRDLIERGADAVKVGIGPGSICTTRVVAGVGVPQITAI
YECAKEADKYGIPVIADGGIKYSGDIVKAIAAGASVVMIGSLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDR
YFQEEAVKLVPEGVEGRVPYRGPLRETVYQLIGGLRAGMGYCGVKNIEELRTKTKFVRITQAGLIESHPHDIIITKEAPN
YNLR

Sequences:

>Translated_484_residues
MEDKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTRLTKKITLNIPLMSAGMDTVTEARLAIAIAREGGIGVIHKNMSIERQ
AMEVDKVKRSEHGVITDPFSLSPDHTIRDAAELMARYKISGVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKENLVT
APPGTTLEEAKQILKKHKIEKLPLVDENNVLKGLITIKDIEKAVEFPNAAKDEKGRLLVAAAVGVGKDMMDRVKALIEAG
VDAIVVDTAHGHSTRVLDAVAKIKEKYPDVQLIAGNVATAEATRDLIERGADAVKVGIGPGSICTTRVVAGVGVPQITAI
YECAKEADKYGIPVIADGGIKYSGDIVKAIAAGASVVMIGSLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDR
YFQEEAVKLVPEGVEGRVPYRGPLRETVYQLIGGLRAGMGYCGVKNIEELRTKTKFVRITQAGLIESHPHDIIITKEAPN
YNLR
>Mature_484_residues
MEDKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTRLTKKITLNIPLMSAGMDTVTEARLAIAIAREGGIGVIHKNMSIERQ
AMEVDKVKRSEHGVITDPFSLSPDHTIRDAAELMARYKISGVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKENLVT
APPGTTLEEAKQILKKHKIEKLPLVDENNVLKGLITIKDIEKAVEFPNAAKDEKGRLLVAAAVGVGKDMMDRVKALIEAG
VDAIVVDTAHGHSTRVLDAVAKIKEKYPDVQLIAGNVATAEATRDLIERGADAVKVGIGPGSICTTRVVAGVGVPQITAI
YECAKEADKYGIPVIADGGIKYSGDIVKAIAAGASVVMIGSLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDR
YFQEEAVKLVPEGVEGRVPYRGPLRETVYQLIGGLRAGMGYCGVKNIEELRTKTKFVRITQAGLIESHPHDIIITKEAPN
YNLR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=45.5114822546973, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=45.7202505219207, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=45.7202505219207, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=45.7202505219207, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=45.7202505219207, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI217035152, Length=473, Percent_Identity=45.6659619450317, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=44.8851774530271, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=42.5887265135699, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI156104880, Length=245, Percent_Identity=38.3673469387755, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=39.1836734693878, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=39.1836734693878, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=39.1836734693878, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=39.1836734693878, Blast_Score=178, Evalue=8e-45,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=60.3305785123967, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786293, Length=343, Percent_Identity=32.9446064139942, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994385, Length=498, Percent_Identity=39.3574297188755, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=41.7061611374408, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=236, Percent_Identity=40.6779661016949, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.344262295082, Blast_Score=348, Evalue=8e-97,
Organism=Saccharomyces cerevisiae, GI6323585, Length=488, Percent_Identity=39.9590163934426, Blast_Score=348, Evalue=8e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=488, Percent_Identity=40.5737704918033, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=40.7514450867052, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=37.9310344827586, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=42.1161825726141, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=42.1161825726141, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=41.8181818181818, Blast_Score=324, Evalue=1e-88,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52461; Mature: 52461

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTRLTKKITLNIPLMSAGMDTVTEARLAI
CCCCHHHCCCCCCCEEEEECCCCCCCCCCCHHHEEEEEEEEECCEECCCCHHHHHCEEEE
AIAREGGIGVIHKNMSIERQAMEVDKVKRSEHGVITDPFSLSPDHTIRDAAELMARYKIS
EEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHEEC
GVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKENLVTAPPGTTLEEAKQILKKHKIE
CCEEEECCEEEEEEECCCEEECCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCC
KLPLVDENNVLKGLITIKDIEKAVEFPNAAKDEKGRLLVAAAVGVGKDMMDRVKALIEAG
CCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCC
VDAIVVDTAHGHSTRVLDAVAKIKEKYPDVQLIAGNVATAEATRDLIERGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGVGVPQITAIYECAKEADKYGIPVIADGGIKYSGDIVKAIAAGASVVMIG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEEE
SLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDRYFQEEAVKLVPEGVEGRVPY
HHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
RGPLRETVYQLIGGLRAGMGYCGVKNIEELRTKTKFVRITQAGLIESHPHDIIITKEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEHHCCCCCCCCCEEEEECCCC
YNLR
CCCC
>Mature Secondary Structure
MEDKFVKEGLTFDDVLLIPAKSDVLPKDVDLKTRLTKKITLNIPLMSAGMDTVTEARLAI
CCCCHHHCCCCCCCEEEEECCCCCCCCCCCHHHEEEEEEEEECCEECCCCHHHHHCEEEE
AIAREGGIGVIHKNMSIERQAMEVDKVKRSEHGVITDPFSLSPDHTIRDAAELMARYKIS
EEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHEEC
GVPITVDSKLVGIITNRDIRFEDDLDKPIREVMTKENLVTAPPGTTLEEAKQILKKHKIE
CCEEEECCEEEEEEECCCEEECCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCC
KLPLVDENNVLKGLITIKDIEKAVEFPNAAKDEKGRLLVAAAVGVGKDMMDRVKALIEAG
CCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCC
VDAIVVDTAHGHSTRVLDAVAKIKEKYPDVQLIAGNVATAEATRDLIERGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCC
GSICTTRVVAGVGVPQITAIYECAKEADKYGIPVIADGGIKYSGDIVKAIAAGASVVMIG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEEE
SLFAGTEESPGEIEIYQGRSYKVYRGMGSLGAMKEGSSDRYFQEEAVKLVPEGVEGRVPY
HHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
RGPLRETVYQLIGGLRAGMGYCGVKNIEELRTKTKFVRITQAGLIESHPHDIIITKEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEEHHCCCCCCCCCEEEEECCCC
YNLR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]