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The map label for this gene is groEL [H]

Identifier: 20807076

GI number: 20807076

Start: 580335

End: 581957

Strand: Direct

Name: groEL [H]

Synonym: TTE0580

Alternate gene names: 20807076

Gene position: 580335-581957 (Clockwise)

Preceding gene: 20807075

Following gene: 20807078

Centisome position: 21.58

GC content: 41.59

Gene sequence:

>1623_bases
ATGGCAAAACAGATCAAATACGGTGAGGAAGCGCGCAAGGCTTTAGAAAGAGGAGTTAATGCTGTTGCTAATACTGTGAA
GGTAACACTGGGTCCAAGAGGAAGGAATGTAGTACTTGACAAGAAATATGGAACTCCTACTGTTACCAATGACGGTGTTA
CAATTGCAAGAGAAATTGAATTAGAAGACCCATTTGAGAATCAAGGTGCTCAGCTTTTGAAAGAGGCTGCAACGAAGACA
AATGATGTAGCGGGTGATGGTACGACTACAGCAACCCTTCTAGCCCAAGTAATGGTTCTGGAAGGGCTTAAAAACCTTGC
TGCGGGTGCCAATCCAATGCTCTTAAGAAGAGGTATGGCAAAGGCTGTGGAAGCCGCAGTCGAGGGTTTAAGAAGGATTT
CTAAGCCTATTGATAATAAAGAGTCAATTGCACATGTAGCTGCTATTTCAGCTGCTGATGAGGAAATTGGACAGCTCATT
GCAGAAGCAATGGAGAAAGTTGGTAAAGACGGTGTCATTACAGTTGAAGAGTCAAAGACTATCGGTACAACTCTTGAAGT
TGTAGAAGGTATGCAGTTTGACAGAGGTTACATCTCACCTTACATGGTAACAGATGCAGAGAAGATGGAAGCAGTACTTG
AAGAGCCTGTAATACTCATCACAGATAAAAAACTCTCTAGTGTGCAAGACTTATTGCCATTGCTAGAGCAAATAGTACAG
CACGGAAAGAAACTTCTCATAATTGCTGATGATGTGGAAGGAGAAGCTTTGGCAACATTAGTTGTTAACAAGTTAAGAGG
TACATTCTCCTGCGTGGCTGTAAAAGCTCCTGGTTTTGGCGACAGAAGAAAGGAAATGCTCCAGGATATTGCTATCTTGA
CAGGTGGGCAAGTAATTTCTGAAGAGTTGGGTTATGACTTAAAAGATGTGACATTAGATATGTTAGGCCGTGCAAGACAG
GTAAAAGTCACAAAAGAACATACAACGATTGTAGGTGGAGCAGGTAATCCAGAAGATATCAAGAAGAGAATTAACCAGAT
AAAGGCTCAAATTGAAGAGACTACTTCAGATTACGATAGAGAGAAATTACAGGAGAGACTTGCTAAACTAGCTGGCGGCG
TAGCAGTTATCCAAGTAGGTGCTGCAACAGAGACAGAGCTCAAAGAGAAGAAACACAGGATTGAAGATGCATTAGCAGCT
ACAAAAGCAGCAGTAGAAGAAGGTATAGTGCCTGGTGGTGGAGTAGCACTTCTTAACGTAATAGAAGATGTGCAGAAAGT
AGTTGACTCATTAGAAGGAGACTTCAAGACAGGGGCCAAGATAGTATTGAAAGCTTTAGAAGCACCTGTAAGGCAGATTG
CTGAAAACGCAGGAGTTGATGGTTCAATAATCGTAGAAAAGATTAAAGCTGCTAAAGATCCGAACTTCGGATACGATGCA
TACAGAGAAGAATTTACAGATATGATCAAGAGAGGTATTATAGACCCGACAAAAGTTACAAGGACAGCACTTCAAAATGC
TGCTTCAATTGCTTCAATGATACTCACAACAGAGGCTATAGTAGTAGATGTGCCAGAGAAAGAAAAAAGCAATATTCCCG
GGGCAGGAATGGACATGATGTAA

Upstream 100 bases:

>100_bases
TCCAAGTACGCTGGGACGGAAGTTAAATTGGATGGCGAAGAATATTTACTTTTAAGAGAGAGCGATATTCTAGCAATAAT
CGAATAAGGAGGTAGTGAAA

Downstream 100 bases:

>100_bases
AGGCTGAGGCTTCCTCAGCCTTTTTTGATTTTCTGCCCTTGACAGATTTTATATTGTCTGATAAAATGAATCTGTACTGA
GGATGTGCGCCCGTAGCTCA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAKQIKYGEEARKALERGVNAVANTVKVTLGPRGRNVVLDKKYGTPTVTNDGVTIAREIELEDPFENQGAQLLKEAATKT
NDVAGDGTTTATLLAQVMVLEGLKNLAAGANPMLLRRGMAKAVEAAVEGLRRISKPIDNKESIAHVAAISAADEEIGQLI
AEAMEKVGKDGVITVEESKTIGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSSVQDLLPLLEQIVQ
HGKKLLIIADDVEGEALATLVVNKLRGTFSCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVTLDMLGRARQ
VKVTKEHTTIVGGAGNPEDIKKRINQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQVGAATETELKEKKHRIEDALAA
TKAAVEEGIVPGGGVALLNVIEDVQKVVDSLEGDFKTGAKIVLKALEAPVRQIAENAGVDGSIIVEKIKAAKDPNFGYDA
YREEFTDMIKRGIIDPTKVTRTALQNAASIASMILTTEAIVVDVPEKEKSNIPGAGMDMM

Sequences:

>Translated_540_residues
MAKQIKYGEEARKALERGVNAVANTVKVTLGPRGRNVVLDKKYGTPTVTNDGVTIAREIELEDPFENQGAQLLKEAATKT
NDVAGDGTTTATLLAQVMVLEGLKNLAAGANPMLLRRGMAKAVEAAVEGLRRISKPIDNKESIAHVAAISAADEEIGQLI
AEAMEKVGKDGVITVEESKTIGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSSVQDLLPLLEQIVQ
HGKKLLIIADDVEGEALATLVVNKLRGTFSCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVTLDMLGRARQ
VKVTKEHTTIVGGAGNPEDIKKRINQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQVGAATETELKEKKHRIEDALAA
TKAAVEEGIVPGGGVALLNVIEDVQKVVDSLEGDFKTGAKIVLKALEAPVRQIAENAGVDGSIIVEKIKAAKDPNFGYDA
YREEFTDMIKRGIIDPTKVTRTALQNAASIASMILTTEAIVVDVPEKEKSNIPGAGMDMM
>Mature_539_residues
AKQIKYGEEARKALERGVNAVANTVKVTLGPRGRNVVLDKKYGTPTVTNDGVTIAREIELEDPFENQGAQLLKEAATKTN
DVAGDGTTTATLLAQVMVLEGLKNLAAGANPMLLRRGMAKAVEAAVEGLRRISKPIDNKESIAHVAAISAADEEIGQLIA
EAMEKVGKDGVITVEESKTIGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSSVQDLLPLLEQIVQH
GKKLLIIADDVEGEALATLVVNKLRGTFSCVAVKAPGFGDRRKEMLQDIAILTGGQVISEELGYDLKDVTLDMLGRARQV
KVTKEHTTIVGGAGNPEDIKKRINQIKAQIEETTSDYDREKLQERLAKLAGGVAVIQVGAATETELKEKKHRIEDALAAT
KAAVEEGIVPGGGVALLNVIEDVQKVVDSLEGDFKTGAKIVLKALEAPVRQIAENAGVDGSIIVEKIKAAKDPNFGYDAY
REEFTDMIKRGIIDPTKVTRTALQNAASIASMILTTEAIVVDVPEKEKSNIPGAGMDMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=49.0566037735849, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=49.0566037735849, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI24307939, Length=555, Percent_Identity=24.5045045045045, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI38455427, Length=545, Percent_Identity=21.8348623853211, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI58331173, Length=552, Percent_Identity=21.9202898550725, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=59.0225563909774, Blast_Score=614, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=47.4480151228733, Blast_Score=493, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=48.3412322274881, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI25144674, Length=567, Percent_Identity=24.8677248677249, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323288, Length=528, Percent_Identity=52.4621212121212, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322524, Length=570, Percent_Identity=23.1578947368421, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322350, Length=529, Percent_Identity=23.4404536862004, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=49.3383742911153, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=49.3383742911153, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=46.6918714555766, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=46.6918714555766, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=46.6918714555766, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=39.5948434622468, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=35.9022556390977, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=35.9022556390977, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24645179, Length=523, Percent_Identity=21.6061185468451, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583944, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57981; Mature: 57849

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIKYGEEARKALERGVNAVANTVKVTLGPRGRNVVLDKKYGTPTVTNDGVTIAREIE
CCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEE
LEDPFENQGAQLLKEAATKTNDVAGDGTTTATLLAQVMVLEGLKNLAAGANPMLLRRGMA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVEAAVEGLRRISKPIDNKESIAHVAAISAADEEIGQLIAEAMEKVGKDGVITVEESKT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSSVQDLLPLLEQIVQ
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
HGKKLLIIADDVEGEALATLVVNKLRGTFSCVAVKAPGFGDRRKEMLQDIAILTGGQVIS
CCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGYDLKDVTLDMLGRARQVKVTKEHTTIVGGAGNPEDIKKRINQIKAQIEETTSDYDR
HHHCCCHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIQVGAATETELKEKKHRIEDALAATKAAVEEGIVPGGGVALLNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IEDVQKVVDSLEGDFKTGAKIVLKALEAPVRQIAENAGVDGSIIVEKIKAAKDPNFGYDA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
YREEFTDMIKRGIIDPTKVTRTALQNAASIASMILTTEAIVVDVPEKEKSNIPGAGMDMM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
AKQIKYGEEARKALERGVNAVANTVKVTLGPRGRNVVLDKKYGTPTVTNDGVTIAREIE
CCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEE
LEDPFENQGAQLLKEAATKTNDVAGDGTTTATLLAQVMVLEGLKNLAAGANPMLLRRGMA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVEAAVEGLRRISKPIDNKESIAHVAAISAADEEIGQLIAEAMEKVGKDGVITVEESKT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IGTTLEVVEGMQFDRGYISPYMVTDAEKMEAVLEEPVILITDKKLSSVQDLLPLLEQIVQ
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
HGKKLLIIADDVEGEALATLVVNKLRGTFSCVAVKAPGFGDRRKEMLQDIAILTGGQVIS
CCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EELGYDLKDVTLDMLGRARQVKVTKEHTTIVGGAGNPEDIKKRINQIKAQIEETTSDYDR
HHHCCCHHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIQVGAATETELKEKKHRIEDALAATKAAVEEGIVPGGGVALLNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IEDVQKVVDSLEGDFKTGAKIVLKALEAPVRQIAENAGVDGSIIVEKIKAAKDPNFGYDA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
YREEFTDMIKRGIIDPTKVTRTALQNAASIASMILTTEAIVVDVPEKEKSNIPGAGMDMM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9795109; 7912671 [H]