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The map label for this gene is guaA

Identifier: 20807079

GI number: 20807079

Start: 584743

End: 586281

Strand: Direct

Name: guaA

Synonym: TTE0583

Alternate gene names: 20807079

Gene position: 584743-586281 (Clockwise)

Preceding gene: 20807078

Following gene: 20807080

Centisome position: 21.74

GC content: 41.13

Gene sequence:

>1539_bases
ATGGGGATTAAGCGCGAAACCATTTTGATTTTGGACTTTGGTGGCCAGTACACTCAGTTAATTGCCAGGAGAATAAGAGA
AGCTAATGTGTATTGCGAGATTGTGCCTTACGATATTTCTCCTGAAGAAATAAAAAAGATAGATCCAAAGGGAATTGTGC
TTTCGGGCGGACCTGCAAGCGTTTATGTGAAAAACGCTCCTAAGTGCGATAAAGAAATTTTTGAATTGGGATACCCTGTT
TTAGGGATATGTTATGGGGTTCAACTTATGACTGAGCTTCTAGGAGGAAAAGTTGCGCCTGCTCCTGTCAGAGAATACGG
CAAGACGGAGGTTGTGATAAACAATACAATTCCGCTTTTTAAAGGGATAGAGAGAGATACCATTGTGTGGATGAGCCACA
CTGACCAAATTGAACTCCCTCCTCCAGATTTTAAAGTTGTGGCTTCTACTGAAAACTGTCCTATTGCAGCTATTGCCAAT
GTAGAAAAAAAACTCTATGGTGTTCAATTCCATCCAGAAGTTTCCCATACTCACAGGGGCACAGAGATAATAAGAAATTT
CCTGTTTGAAGTGTGCGATTGCTCCGCTGATTGGACGATGGATTCTTTGATTGAACAGACTGTAAAAGAAGTGAGAGCTA
AAGTAGGTAATCACAAGGCTGTATGCGCTCTATCGGGCGGTGTAGATTCAGCTGTTGCAGCAGTCCTTGTAGATAGAGCT
ATACACGATCAGCTAGTGTGCATATTTGTAGATACTGGGCTTTTGCGGACAAACGAAGGGGATATGGTAATTGAAACTTT
CAGAAAGAATTACGATATGAATATAATAAGAGTTGACGCAAAAGACAGATTTCTCTCGAGGCTTAAAGGAGTTACTGACC
CGGAGGAGAAGAGGAAGATCATTGGAAATGTTTTCATAGAAGTTTTTAAAGAAGAAGCCATGAAGATTGGCGATGTAAAG
TTTTTGGTTCAGGGGACTTTATATCCTGATGTGATTGAAAGCGGGCATGGGATTTCATCTACCATAAAAAGTCATCACAA
TGTCGGCGGACTTCCTGAAGATATCGGATTTGAGTTAATTGAGCCTTTACGAATGCTTTTTAAAGATGAAGTCAGACAAG
TAGGTAAGGAATTAGGGATTCCCGATGAGATATTGTATAGACAGCCTTTCCCTGGCCCCGGACTGGCTGTGAGAATTGTA
GGAGAAGTTACAGAAGAAAAATTAGAAATTTTAAGGCTGGCTGACAGCATAGTTCAGAGAGAGATGAAAAGATTTGGATG
GTACAATAAGGTGTGGCAGTCGTTTGCTATTTTGCCTGGAATAAAGAGTGTGGGAGTAATGGGGGACGAGAGGACATACG
GTTATGCTATAATTTTGAGGGTTGTAGATAGTATGGACGGTATGACGGCTGATTGGACAAAACTGCCTTATGAAATTTTG
GAAAGCATCTCTACCAGCATTACGAATGAAGTGCCGGGAGTTAACAGGGTTTTATACGATATAACTTCAAAGCCTCCTGC
TACTATAGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GTAAGAATAACACAGGCAGGGTTAATTGAAAGTCACCCTCATGATATAATTATTACGAAAGAAGCTCCTAATTATAATTT
GAGATAAGAGGAGGATTTTG

Downstream 100 bases:

>100_bases
AAACGAACATTAAAAGAAATTTCTTTAAAAAAATTCGTAGTATCTATTGACTTTTTGTTAAATAGTTGCTAAGATATATT
TAGAAAAATTTAATAAGAAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MGIKRETILILDFGGQYTQLIARRIREANVYCEIVPYDISPEEIKKIDPKGIVLSGGPASVYVKNAPKCDKEIFELGYPV
LGICYGVQLMTELLGGKVAPAPVREYGKTEVVINNTIPLFKGIERDTIVWMSHTDQIELPPPDFKVVASTENCPIAAIAN
VEKKLYGVQFHPEVSHTHRGTEIIRNFLFEVCDCSADWTMDSLIEQTVKEVRAKVGNHKAVCALSGGVDSAVAAVLVDRA
IHDQLVCIFVDTGLLRTNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKIIGNVFIEVFKEEAMKIGDVK
FLVQGTLYPDVIESGHGISSTIKSHHNVGGLPEDIGFELIEPLRMLFKDEVRQVGKELGIPDEILYRQPFPGPGLAVRIV
GEVTEEKLEILRLADSIVQREMKRFGWYNKVWQSFAILPGIKSVGVMGDERTYGYAIILRVVDSMDGMTADWTKLPYEIL
ESISTSITNEVPGVNRVLYDITSKPPATIEWE

Sequences:

>Translated_512_residues
MGIKRETILILDFGGQYTQLIARRIREANVYCEIVPYDISPEEIKKIDPKGIVLSGGPASVYVKNAPKCDKEIFELGYPV
LGICYGVQLMTELLGGKVAPAPVREYGKTEVVINNTIPLFKGIERDTIVWMSHTDQIELPPPDFKVVASTENCPIAAIAN
VEKKLYGVQFHPEVSHTHRGTEIIRNFLFEVCDCSADWTMDSLIEQTVKEVRAKVGNHKAVCALSGGVDSAVAAVLVDRA
IHDQLVCIFVDTGLLRTNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKIIGNVFIEVFKEEAMKIGDVK
FLVQGTLYPDVIESGHGISSTIKSHHNVGGLPEDIGFELIEPLRMLFKDEVRQVGKELGIPDEILYRQPFPGPGLAVRIV
GEVTEEKLEILRLADSIVQREMKRFGWYNKVWQSFAILPGIKSVGVMGDERTYGYAIILRVVDSMDGMTADWTKLPYEIL
ESISTSITNEVPGVNRVLYDITSKPPATIEWE
>Mature_511_residues
GIKRETILILDFGGQYTQLIARRIREANVYCEIVPYDISPEEIKKIDPKGIVLSGGPASVYVKNAPKCDKEIFELGYPVL
GICYGVQLMTELLGGKVAPAPVREYGKTEVVINNTIPLFKGIERDTIVWMSHTDQIELPPPDFKVVASTENCPIAAIANV
EKKLYGVQFHPEVSHTHRGTEIIRNFLFEVCDCSADWTMDSLIEQTVKEVRAKVGNHKAVCALSGGVDSAVAAVLVDRAI
HDQLVCIFVDTGLLRTNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKIIGNVFIEVFKEEAMKIGDVKF
LVQGTLYPDVIESGHGISSTIKSHHNVGGLPEDIGFELIEPLRMLFKDEVRQVGKELGIPDEILYRQPFPGPGLAVRIVG
EVTEEKLEILRLADSIVQREMKRFGWYNKVWQSFAILPGIKSVGVMGDERTYGYAIILRVVDSMDGMTADWTKLPYEILE
SISTSITNEVPGVNRVLYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=35.8318098720293, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=51.7241379310345, Blast_Score=563, Evalue=1e-161,
Organism=Escherichia coli, GI1789760, Length=148, Percent_Identity=31.7567567567568, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=37.4781085814361, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=37.4781085814361, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=37.5438596491228, Blast_Score=324, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=50.3875968992248, Blast_Score=519, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322638, Length=160, Percent_Identity=34.375, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281365319, Length=554, Percent_Identity=35.1985559566787, Blast_Score=311, Evalue=7e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_THETN (Q8RC63)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622250.1
- ProteinModelPortal:   Q8RC63
- SMR:   Q8RC63
- GeneID:   996373
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0583
- NMPDR:   fig|273068.3.peg.1233
- HOGENOM:   HBG391775
- OMA:   QDICGCE
- ProtClustDB:   PRK00074
- BioCyc:   TTEN273068:TTE0583-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57272; Mature: 57141

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 84-84 ACT_SITE 171-171 ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIKRETILILDFGGQYTQLIARRIREANVYCEIVPYDISPEEIKKIDPKGIVLSGGPAS
CCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCEEEECCCCE
VYVKNAPKCDKEIFELGYPVLGICYGVQLMTELLGGKVAPAPVREYGKTEVVINNTIPLF
EEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCHHH
KGIERDTIVWMSHTDQIELPPPDFKVVASTENCPIAAIANVEKKLYGVQFHPEVSHTHRG
CCCCCCEEEEEECCCEECCCCCCCEEEEECCCCCEEEHHHHHHHHCCEEECCCCCCCCCH
TEIIRNFLFEVCDCSADWTMDSLIEQTVKEVRAKVGNHKAVCALSGGVDSAVAAVLVDRA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
IHDQLVCIFVDTGLLRTNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKI
HHCCEEEEEEECCCEEECCCCCHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHH
IGNVFIEVFKEEAMKIGDVKFLVQGTLYPDVIESGHGISSTIKSHHNVGGLPEDIGFELI
HHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHH
EPLRMLFKDEVRQVGKELGIPDEILYRQPFPGPGLAVRIVGEVTEEKLEILRLADSIVQR
HHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
EMKRFGWYNKVWQSFAILPGIKSVGVMGDERTYGYAIILRVVDSMDGMTADWTKLPYEIL
HHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCHHHH
ESISTSITNEVPGVNRVLYDITSKPPATIEWE
HHHHHHHHHCCCCCHHHHEECCCCCCCEEECC
>Mature Secondary Structure 
GIKRETILILDFGGQYTQLIARRIREANVYCEIVPYDISPEEIKKIDPKGIVLSGGPAS
CCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCEEEECCCCE
VYVKNAPKCDKEIFELGYPVLGICYGVQLMTELLGGKVAPAPVREYGKTEVVINNTIPLF
EEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCHHH
KGIERDTIVWMSHTDQIELPPPDFKVVASTENCPIAAIANVEKKLYGVQFHPEVSHTHRG
CCCCCCEEEEEECCCEECCCCCCCEEEEECCCCCEEEHHHHHHHHCCEEECCCCCCCCCH
TEIIRNFLFEVCDCSADWTMDSLIEQTVKEVRAKVGNHKAVCALSGGVDSAVAAVLVDRA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
IHDQLVCIFVDTGLLRTNEGDMVIETFRKNYDMNIIRVDAKDRFLSRLKGVTDPEEKRKI
HHCCEEEEEEECCCEEECCCCCHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCHHHHHHH
IGNVFIEVFKEEAMKIGDVKFLVQGTLYPDVIESGHGISSTIKSHHNVGGLPEDIGFELI
HHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHH
EPLRMLFKDEVRQVGKELGIPDEILYRQPFPGPGLAVRIVGEVTEEKLEILRLADSIVQR
HHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
EMKRFGWYNKVWQSFAILPGIKSVGVMGDERTYGYAIILRVVDSMDGMTADWTKLPYEIL
HHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCHHHH
ESISTSITNEVPGVNRVLYDITSKPPATIEWE
HHHHHHHHHCCCCCHHHHEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336