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The map label for this gene is FadB [H]

Identifier: 20807049

GI number: 20807049

Start: 554485

End: 555330

Strand: Direct

Name: FadB [H]

Synonym: TTE0548

Alternate gene names: 20807049

Gene position: 554485-555330 (Clockwise)

Preceding gene: 20807048

Following gene: 20807050

Centisome position: 20.62

GC content: 37.12

Gene sequence:

>846_bases
ATGCAAAAAATATTTGTAGTTGGTGCAGGAACAATGGGATCGGGAATTGCACAGGTATTTGCAGAAAATGGTTTTGAAGT
TGTAGTAAGGGATATAGATATGAAATTTGTAGAAAGAGCTTTAGGAGTTATTGAAAGTAACCTTAAAAGAAATGTAGAAA
AAGGGAAAATTACAGAAGAAAAGAAAAACGAGGTGTTAAGTAGAATAAGAGGCACTGTTGATATTGACGAAGCTAGGGAA
GCTGATTTTGTCATTGAAGCGGCTGTAGAAAATATGGAGATAAAAAAAGAAATTTTTAGAGAGCTTGATAACGTATGCAG
AAAAGAGGTAATACTTGCCACAAACACTTCTTCTCTTTCAATAACAGAAATAGCAAGTAGCACTCAAAGGCCTGAAAAAG
TAATAGGCATGCACTTTTTTAATCCCGTACCTGTGATGAAATTGGTGGAAGTGATAAGAGGGATGAAGACCTCTGATGAG
ACATTCAATACGGTAAAAGAACTGGCTCAAAAGCTTGGGAAAACCCCAGTTGAAGTCAATGAAGCCCCTGGTTTCGTGGT
AAACAGGATTTTGATTCCCATGATAAACGAAGCTATAGGAGTTTTGGCAGATGGAGTAGCTTCTGCAGAGGATATTGATG
AAGCCATGAAATTGGGGGCAAACCATCCAATAGGACCCCTTGCCCTTTCTGACCTTATAGGGAATGATGTAGTTCTTGCA
ATAATGGAAGTATTATATCAAGAATTTGGAGATCCTAAATACAGGCCTCATCCACTTTTAAAGAAAATGGTGAGAGCGGG
CTTTTTAGGTAGAAAAACTGGTAAAGGATTTTTTGAATATAAATAA

Upstream 100 bases:

>100_bases
GTAATAAAGTAGTAGTGACTTATGTATGTTTATCAAGAAGGGCGGCTGACCTTTTGGCAGCTGACTCTTTTACAATAAAT
TTCTAGGAGGGAAATGCAAA

Downstream 100 bases:

>100_bases
AAATTAAAAAGGGGGATTTATATGAGAGAAGCTGTAATCGTGAGTGCAGTGAGAACTGCAATAGGAAAGTTTGGAGGAAG
CCTGGCTGGAATTCCAGTAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQKIFVVGAGTMGSGIAQVFAENGFEVVVRDIDMKFVERALGVIESNLKRNVEKGKITEEKKNEVLSRIRGTVDIDEARE
ADFVIEAAVENMEIKKEIFRELDNVCRKEVILATNTSSLSITEIASSTQRPEKVIGMHFFNPVPVMKLVEVIRGMKTSDE
TFNTVKELAQKLGKTPVEVNEAPGFVVNRILIPMINEAIGVLADGVASAEDIDEAMKLGANHPIGPLALSDLIGNDVVLA
IMEVLYQEFGDPKYRPHPLLKKMVRAGFLGRKTGKGFFEYK

Sequences:

>Translated_281_residues
MQKIFVVGAGTMGSGIAQVFAENGFEVVVRDIDMKFVERALGVIESNLKRNVEKGKITEEKKNEVLSRIRGTVDIDEARE
ADFVIEAAVENMEIKKEIFRELDNVCRKEVILATNTSSLSITEIASSTQRPEKVIGMHFFNPVPVMKLVEVIRGMKTSDE
TFNTVKELAQKLGKTPVEVNEAPGFVVNRILIPMINEAIGVLADGVASAEDIDEAMKLGANHPIGPLALSDLIGNDVVLA
IMEVLYQEFGDPKYRPHPLLKKMVRAGFLGRKTGKGFFEYK
>Mature_281_residues
MQKIFVVGAGTMGSGIAQVFAENGFEVVVRDIDMKFVERALGVIESNLKRNVEKGKITEEKKNEVLSRIRGTVDIDEARE
ADFVIEAAVENMEIKKEIFRELDNVCRKEVILATNTSSLSITEIASSTQRPEKVIGMHFFNPVPVMKLVEVIRGMKTSDE
TFNTVKELAQKLGKTPVEVNEAPGFVVNRILIPMINEAIGVLADGVASAEDIDEAMKLGANHPIGPLALSDLIGNDVVLA
IMEVLYQEFGDPKYRPHPLLKKMVRAGFLGRKTGKGFFEYK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.9065743944637, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=40.8496732026144, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=36.8794326241135, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI261878539, Length=288, Percent_Identity=37.8472222222222, Blast_Score=160, Evalue=9e-40,
Organism=Homo sapiens, GI68989263, Length=288, Percent_Identity=37.8472222222222, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=33.0434782608696, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=42.5531914893617, Blast_Score=240, Evalue=8e-65,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=39.8496240601504, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=39.1472868217054, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=43.9024390243902, Blast_Score=246, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=41.522491349481, Blast_Score=226, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=39.7212543554007, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=39.426523297491, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=39.0070921985816, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=39.0070921985816, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=38.3802816901408, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=34.2857142857143, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985930, Length=277, Percent_Identity=32.129963898917, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=26.7326732673267, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=26.7326732673267, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.2340425531915, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.2340425531915, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.2340425531915, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=28.0542986425339, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31066; Mature: 31066

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIFVVGAGTMGSGIAQVFAENGFEVVVRDIDMKFVERALGVIESNLKRNVEKGKITEE
CCEEEEEECCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KKNEVLSRIRGTVDIDEAREADFVIEAAVENMEIKKEIFRELDNVCRKEVILATNTSSLS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
ITEIASSTQRPEKVIGMHFFNPVPVMKLVEVIRGMKTSDETFNTVKELAQKLGKTPVEVN
HHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
EAPGFVVNRILIPMINEAIGVLADGVASAEDIDEAMKLGANHPIGPLALSDLIGNDVVLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHH
IMEVLYQEFGDPKYRPHPLLKKMVRAGFLGRKTGKGFFEYK
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKIFVVGAGTMGSGIAQVFAENGFEVVVRDIDMKFVERALGVIESNLKRNVEKGKITEE
CCEEEEEECCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KKNEVLSRIRGTVDIDEAREADFVIEAAVENMEIKKEIFRELDNVCRKEVILATNTSSLS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
ITEIASSTQRPEKVIGMHFFNPVPVMKLVEVIRGMKTSDETFNTVKELAQKLGKTPVEVN
HHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
EAPGFVVNRILIPMINEAIGVLADGVASAEDIDEAMKLGANHPIGPLALSDLIGNDVVLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHH
IMEVLYQEFGDPKYRPHPLLKKMVRAGFLGRKTGKGFFEYK
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA