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The map label for this gene is PaaJ [H]

Identifier: 20807050

GI number: 20807050

Start: 555352

End: 556536

Strand: Direct

Name: PaaJ [H]

Synonym: TTE0549

Alternate gene names: 20807050

Gene position: 555352-556536 (Clockwise)

Preceding gene: 20807049

Following gene: 20807051

Centisome position: 20.65

GC content: 44.81

Gene sequence:

>1185_bases
ATGAGAGAAGCTGTAATCGTGAGTGCAGTGAGAACTGCAATAGGAAAGTTTGGAGGAAGCCTGGCTGGAATTCCAGTAGT
GGACTTAGGAGCAATTGTTATAAAAGAGGCATTAAAAAGAGCAAAAGTAGCTCCAGAACAGGTAGATGAAGTATTCATGG
GCATTATATTACAGGCGGGCTTAGGTCAAAATCCTGCGAGGCAGTCTGCTGTAAAAGCGGGAATTCCTGTGGAGGTACCT
GCTACAACGATAAACATGGTATGTGGTTCAGGACTTAGAACTGTGGCTATGGCAGCTCAAGCTGTTATGCTAGGGGATGC
TGATATAGTTGTGGCGGGCGGTATGGAAAGCATGTCAAGAGCTCCGTATTTACTGAGAGATGCCCGCTGGGGTTACAGGA
TGAACATGCCTTCTGGAGAGCTTGTTGATGAGATGGTCTATGACGGGCTGTGGGATGTTTTCAATCAGTACCACATGGGC
ATAACAGCAGAGAACATTGCAGAAAGGTACAAAATTTCAAGGCAGGAACAGGATGAATTTGCGCTAAGAAGTCAAAACTT
AGCTGAGGCTGCCATAAAAGCGGGAAAATTTGAAGAAGAGATTGTTCCTGTGCCCATTCCTCAGAAGAAAGGAGATCCAA
TTGAATTTAAGGTAGATGAGCATCCTAGATTTGGAACTACTATGGAGGACCTGGCGAAATTAAAACCTGCCTTCAAGCCG
GATGGAACAGTCACAGCAGGAAATGCTTCTGGAATAAATGATGGAGCGGCTGCAGTAGTAGTTATGTCAAGAGATAAGGC
AAAAGAGCTGGGCGTAACTCCTCTTGCGACTATAAAATCTTATGCCTACGCTGGCGTTGACCCGGCTGTAATGGGTCTAG
GTCCAATTTACTCAACAAGAAAAGCTCTTGACAAGGCAGGCTTGAAGATAGAGGACATTGACCTTATAGAAGCCAATGAA
GCTTTTGCAGCTCAAGCAATAGCAGTAGCTAGAGAGCTTAACTTTGATATGGAGAAAGTGAATGTAAACGGAGGTGCAAT
AGCTCTAGGTCATCCGATTGGGGCAAGTGGAGCGAGAATTTTAGTGACTCTTCTTCACGAAATGAAAAGAAGAGGTTCCC
GTTTAGGTCTTGCTACACTTTGCATAGGCGGTGGCATGGGTATATCAATGATTGTGGAGATGTAA

Upstream 100 bases:

>100_bases
TCATCCACTTTTAAAGAAAATGGTGAGAGCGGGCTTTTTAGGTAGAAAAACTGGTAAAGGATTTTTTGAATATAAATAAA
AATTAAAAAGGGGGATTTAT

Downstream 100 bases:

>100_bases
AATGGAAAAAACAAGTCAATAACCCTCGGCTGTGCCGGGGGTTATTGACTTTTTATAACGATTACGTGTATAATGGACAT
CAAAAGATGTACTAAAATGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MREAVIVSAVRTAIGKFGGSLAGIPVVDLGAIVIKEALKRAKVAPEQVDEVFMGIILQAGLGQNPARQSAVKAGIPVEVP
ATTINMVCGSGLRTVAMAAQAVMLGDADIVVAGGMESMSRAPYLLRDARWGYRMNMPSGELVDEMVYDGLWDVFNQYHMG
ITAENIAERYKISRQEQDEFALRSQNLAEAAIKAGKFEEEIVPVPIPQKKGDPIEFKVDEHPRFGTTMEDLAKLKPAFKP
DGTVTAGNASGINDGAAAVVVMSRDKAKELGVTPLATIKSYAYAGVDPAVMGLGPIYSTRKALDKAGLKIEDIDLIEANE
AFAAQAIAVARELNFDMEKVNVNGGAIALGHPIGASGARILVTLLHEMKRRGSRLGLATLCIGGGMGISMIVEM

Sequences:

>Translated_394_residues
MREAVIVSAVRTAIGKFGGSLAGIPVVDLGAIVIKEALKRAKVAPEQVDEVFMGIILQAGLGQNPARQSAVKAGIPVEVP
ATTINMVCGSGLRTVAMAAQAVMLGDADIVVAGGMESMSRAPYLLRDARWGYRMNMPSGELVDEMVYDGLWDVFNQYHMG
ITAENIAERYKISRQEQDEFALRSQNLAEAAIKAGKFEEEIVPVPIPQKKGDPIEFKVDEHPRFGTTMEDLAKLKPAFKP
DGTVTAGNASGINDGAAAVVVMSRDKAKELGVTPLATIKSYAYAGVDPAVMGLGPIYSTRKALDKAGLKIEDIDLIEANE
AFAAQAIAVARELNFDMEKVNVNGGAIALGHPIGASGARILVTLLHEMKRRGSRLGLATLCIGGGMGISMIVEM
>Mature_394_residues
MREAVIVSAVRTAIGKFGGSLAGIPVVDLGAIVIKEALKRAKVAPEQVDEVFMGIILQAGLGQNPARQSAVKAGIPVEVP
ATTINMVCGSGLRTVAMAAQAVMLGDADIVVAGGMESMSRAPYLLRDARWGYRMNMPSGELVDEMVYDGLWDVFNQYHMG
ITAENIAERYKISRQEQDEFALRSQNLAEAAIKAGKFEEEIVPVPIPQKKGDPIEFKVDEHPRFGTTMEDLAKLKPAFKP
DGTVTAGNASGINDGAAAVVVMSRDKAKELGVTPLATIKSYAYAGVDPAVMGLGPIYSTRKALDKAGLKIEDIDLIEANE
AFAAQAIAVARELNFDMEKVNVNGGAIALGHPIGASGARILVTLLHEMKRRGSRLGLATLCIGGGMGISMIVEM

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=56.6326530612245, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI167614485, Length=398, Percent_Identity=46.4824120603015, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=46.2121212121212, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=44.8362720403023, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=33.6448598130841, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.5521628498728, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=56.234096692112, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=61.1675126903553, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=48.0099502487562, Blast_Score=344, Evalue=6e-96,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=41, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=36.8171021377672, Blast_Score=228, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=49.3573264781491, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=39.0862944162437, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=37.3737373737374, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=36.4485981308411, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=31.5656565656566, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=43.5443037974684, Blast_Score=293, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=38.4810126582278, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=54.70737913486, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=45.4314720812183, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=32.5471698113208, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41806; Mature: 41806

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVSAVRTAIGKFGGSLAGIPVVDLGAIVIKEALKRAKVAPEQVDEVFMGIILQAG
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
LGQNPARQSAVKAGIPVEVPATTINMVCGSGLRTVAMAAQAVMLGDADIVVAGGMESMSR
CCCCHHHHHHHHCCCCEECCHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCHHHHHC
APYLLRDARWGYRMNMPSGELVDEMVYDGLWDVFNQYHMGITAENIAERYKISRQEQDEF
CCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHH
ALRSQNLAEAAIKAGKFEEEIVPVPIPQKKGDPIEFKVDEHPRFGTTMEDLAKLKPAFKP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCC
DGTVTAGNASGINDGAAAVVVMSRDKAKELGVTPLATIKSYAYAGVDPAVMGLGPIYSTR
CCCEECCCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHHCCCCHHHHCCCCHHHHH
KALDKAGLKIEDIDLIEANEAFAAQAIAVARELNFDMEKVNVNGGAIALGHPIGASGARI
HHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHH
LVTLLHEMKRRGSRLGLATLCIGGGMGISMIVEM
HHHHHHHHHHCCCCCCEEHEEECCCCCCEEEEEC
>Mature Secondary Structure
MREAVIVSAVRTAIGKFGGSLAGIPVVDLGAIVIKEALKRAKVAPEQVDEVFMGIILQAG
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
LGQNPARQSAVKAGIPVEVPATTINMVCGSGLRTVAMAAQAVMLGDADIVVAGGMESMSR
CCCCHHHHHHHHCCCCEECCHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCHHHHHC
APYLLRDARWGYRMNMPSGELVDEMVYDGLWDVFNQYHMGITAENIAERYKISRQEQDEF
CCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHH
ALRSQNLAEAAIKAGKFEEEIVPVPIPQKKGDPIEFKVDEHPRFGTTMEDLAKLKPAFKP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCC
DGTVTAGNASGINDGAAAVVVMSRDKAKELGVTPLATIKSYAYAGVDPAVMGLGPIYSTR
CCCEECCCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHHCCCCHHHHCCCCHHHHH
KALDKAGLKIEDIDLIEANEAFAAQAIAVARELNFDMEKVNVNGGAIALGHPIGASGARI
HHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHH
LVTLLHEMKRRGSRLGLATLCIGGGMGISMIVEM
HHHHHHHHHHCCCCCCEEHEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]