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The map label for this gene is CaiA [H]

Identifier: 20807046

GI number: 20807046

Start: 551415

End: 552557

Strand: Direct

Name: CaiA [H]

Synonym: TTE0545

Alternate gene names: 20807046

Gene position: 551415-552557 (Clockwise)

Preceding gene: 20807045

Following gene: 20807047

Centisome position: 20.5

GC content: 41.21

Gene sequence:

>1143_bases
ATGGATTTTTCTTTTACCAGAGAACAAGAGATGGTGAGAAAAGTAGTGAGGGAATTTGCAGAGAAGGAGATTATGCCACG
CGCAAAAGAAATTGATAGAACAGGGGAGTTTCCATGGGATAACGTTAAAAAAATGGCGAATGCCGATATGATGGGGATTC
CCTATCCAAAGGAATATGGAGGAGCAGGAGGAGATTACATAAGTTACATCATCACTGTTGAAGAAATATCTCGCGCTTGT
GCAGCTACAGGGGTGATACTTTCTGCCCATACATCACTAGCATGTTTTCCTATTTTCCAGTGGGGAACAAAAGAGCAAAA
AGAAAAATACCTTGTACCACTTGCAAGAGGGGAGAAATTAGGGGCTTTTGCTTTGACAGAGCCTAACGCTGGAACTGATG
CAGCAGGCATTCAAACAACTGCTACGTTAGAAGGGGACCATTATGTATTAAACGGCTGTAAAATCTTCATTACCAATGGT
GGTGTGGCGGATGTATATATAGTTTTTGCTAAGACAGATAAATCTCAAGGAGCTAAAGGGATAAGTGCCTTTATTGTAGA
AAAAGGCTTTCCGGGTTTTTCTATAGGTAAAATAGAAGAGAAGATGGGGATAAGGGGTTCAAGGGCGGCAGAACTGGTTT
TTGAAGACTGTATAGTGCCAAAAGAAAATTTGCTCGGCAAAGAAGGGGAAGGATTTAAGATAGCTATGGTGACTTTAGAT
GGTGGGAGAATAGGCATTGGTGCTCAAGCTCTAGGAATTGCTCAGGCAGCTTTGGATGAAGTTATAAAATATGTAAAGGA
AAGGCAACAGTTTGGAAGGCCTATAGGGAAATTTCAAGGGTTGCAGTGGTATATTGCCGAGATGGCAACAAAGGTGAGTG
CAGCCAGACATCTTGTCTATTATGCTGCCTGGAGAAAGGAAAACAACTTAAGTTACAGCATGGAAGCCGCAATGGCAAAA
CTTTTTGCCTCAGAGACGGCTATGGAGGTTACTACTAAAGCGGTGCAAATTTTTGGCGGCTACGGCTATACAAAAGATTA
TCCTGTAGAAAGGCTTATGAGGGATGCAAAGATTACGGAAATATATGAAGGTACATCAGAAGTTCAGAAAATGGTCATTG
CTTCAAATATTTTAAAGATGTAA

Upstream 100 bases:

>100_bases
TTTTTTAGAGAAGAGAGCTCCTAAATTTGAAGGAAGATGAGGGGAATGCCCCTCACTGTACCCTAGAATGTTAAAAAAAT
ATCAAAAAGGAGGAGTGTAT

Downstream 100 bases:

>100_bases
GGAGGGAACTATCATGAACATTATTGTTTGCATAAAGCAGGTGCCTGACACAAGTGAAGTGAAGATAGACCCTGTCACAA
AGACTCTCATAAGAGAAGGA

Product: Acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MDFSFTREQEMVRKVVREFAEKEIMPRAKEIDRTGEFPWDNVKKMANADMMGIPYPKEYGGAGGDYISYIITVEEISRAC
AATGVILSAHTSLACFPIFQWGTKEQKEKYLVPLARGEKLGAFALTEPNAGTDAAGIQTTATLEGDHYVLNGCKIFITNG
GVADVYIVFAKTDKSQGAKGISAFIVEKGFPGFSIGKIEEKMGIRGSRAAELVFEDCIVPKENLLGKEGEGFKIAMVTLD
GGRIGIGAQALGIAQAALDEVIKYVKERQQFGRPIGKFQGLQWYIAEMATKVSAARHLVYYAAWRKENNLSYSMEAAMAK
LFASETAMEVTTKAVQIFGGYGYTKDYPVERLMRDAKITEIYEGTSEVQKMVIASNILKM

Sequences:

>Translated_380_residues
MDFSFTREQEMVRKVVREFAEKEIMPRAKEIDRTGEFPWDNVKKMANADMMGIPYPKEYGGAGGDYISYIITVEEISRAC
AATGVILSAHTSLACFPIFQWGTKEQKEKYLVPLARGEKLGAFALTEPNAGTDAAGIQTTATLEGDHYVLNGCKIFITNG
GVADVYIVFAKTDKSQGAKGISAFIVEKGFPGFSIGKIEEKMGIRGSRAAELVFEDCIVPKENLLGKEGEGFKIAMVTLD
GGRIGIGAQALGIAQAALDEVIKYVKERQQFGRPIGKFQGLQWYIAEMATKVSAARHLVYYAAWRKENNLSYSMEAAMAK
LFASETAMEVTTKAVQIFGGYGYTKDYPVERLMRDAKITEIYEGTSEVQKMVIASNILKM
>Mature_380_residues
MDFSFTREQEMVRKVVREFAEKEIMPRAKEIDRTGEFPWDNVKKMANADMMGIPYPKEYGGAGGDYISYIITVEEISRAC
AATGVILSAHTSLACFPIFQWGTKEQKEKYLVPLARGEKLGAFALTEPNAGTDAAGIQTTATLEGDHYVLNGCKIFITNG
GVADVYIVFAKTDKSQGAKGISAFIVEKGFPGFSIGKIEEKMGIRGSRAAELVFEDCIVPKENLLGKEGEGFKIAMVTLD
GGRIGIGAQALGIAQAALDEVIKYVKERQQFGRPIGKFQGLQWYIAEMATKVSAARHLVYYAAWRKENNLSYSMEAAMAK
LFASETAMEVTTKAVQIFGGYGYTKDYPVERLMRDAKITEIYEGTSEVQKMVIASNILKM

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=50.9433962264151, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=42.5531914893617, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=42.5133689839572, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI226958414, Length=333, Percent_Identity=44.1441441441441, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=41.3333333333333, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=41.3333333333333, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=38.4615384615385, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=41.9618528610354, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=38.2352941176471, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=38.2352941176471, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=35.8090185676393, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=28.9473684210526, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=29.2349726775956, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI211971008, Length=342, Percent_Identity=30.1169590643275, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI48976061, Length=342, Percent_Identity=30.1169590643275, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI38505218, Length=401, Percent_Identity=25.6857855361596, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI218563752, Length=238, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=30, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=31.331592689295, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082384, Length=312, Percent_Identity=25.6410256410256, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081702, Length=308, Percent_Identity=26.2987012987013, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=41.6216216216216, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=40.4825737265416, Blast_Score=297, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=41.6230366492147, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=40.1574803149606, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=40.5759162303665, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=40.6824146981627, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=39.572192513369, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=45.2380952380952, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=40.1709401709402, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=32.5333333333333, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71985192, Length=297, Percent_Identity=39.7306397306397, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=40.6113537117904, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=35.6617647058824, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=29.9191374663073, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=29.2349726775956, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.4398340248963, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=332, Percent_Identity=28.9156626506024, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=32.9608938547486, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=27.8195488721804, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=269, Percent_Identity=27.5092936802974, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=364, Percent_Identity=23.9010989010989, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=50.531914893617, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=44.9468085106383, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=41.9525065963061, Blast_Score=300, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=41.8666666666667, Blast_Score=297, Evalue=6e-81,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=39.5287958115183, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI281363737, Length=338, Percent_Identity=39.6449704142012, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=28.3464566929134, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI45550141, Length=316, Percent_Identity=26.2658227848101, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221473076, Length=316, Percent_Identity=26.2658227848101, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41854; Mature: 41854

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSFTREQEMVRKVVREFAEKEIMPRAKEIDRTGEFPWDNVKKMANADMMGIPYPKEYG
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHC
GAGGDYISYIITVEEISRACAATGVILSAHTSLACFPIFQWGTKEQKEKYLVPLARGEKL
CCCCCCEEEEEEHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCCCCHHEEEEECCCCCC
GAFALTEPNAGTDAAGIQTTATLEGDHYVLNGCKIFITNGGVADVYIVFAKTDKSQGAKG
CEEEEECCCCCCCCCCCEEEEEECCCEEEEECEEEEEECCCCEEEEEEEEECCCCCCCCC
ISAFIVEKGFPGFSIGKIEEKMGIRGSRAAELVFEDCIVPKENLLGKEGEGFKIAMVTLD
CEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEEC
GGRIGIGAQALGIAQAALDEVIKYVKERQQFGRPIGKFQGLQWYIAEMATKVSAARHLVY
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHE
YAAWRKENNLSYSMEAAMAKLFASETAMEVTTKAVQIFGGYGYTKDYPVERLMRDAKITE
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIASNILKM
HHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFSFTREQEMVRKVVREFAEKEIMPRAKEIDRTGEFPWDNVKKMANADMMGIPYPKEYG
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHC
GAGGDYISYIITVEEISRACAATGVILSAHTSLACFPIFQWGTKEQKEKYLVPLARGEKL
CCCCCCEEEEEEHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCCCCHHEEEEECCCCCC
GAFALTEPNAGTDAAGIQTTATLEGDHYVLNGCKIFITNGGVADVYIVFAKTDKSQGAKG
CEEEEECCCCCCCCCCCEEEEEECCCEEEEECEEEEEECCCCEEEEEEEEECCCCCCCCC
ISAFIVEKGFPGFSIGKIEEKMGIRGSRAAELVFEDCIVPKENLLGKEGEGFKIAMVTLD
CEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEEC
GGRIGIGAQALGIAQAALDEVIKYVKERQQFGRPIGKFQGLQWYIAEMATKVSAARHLVY
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHE
YAAWRKENNLSYSMEAAMAKLFASETAMEVTTKAVQIFGGYGYTKDYPVERLMRDAKITE
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIASNILKM
HHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]