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The map label for this gene is ThrA [H]

Identifier: 20094990

GI number: 20094990

Start: 1569260

End: 1570273

Strand: Direct

Name: ThrA [H]

Synonym: MK1554

Alternate gene names: 20094990

Gene position: 1569260-1570273 (Clockwise)

Preceding gene: 20094989

Following gene: 20094996

Centisome position: 92.58

GC content: 60.26

Gene sequence:

>1014_bases
GTGCGTCAGGCGCGCCTCTTCGTGATCGGCCTCGGGGCCGTTGGGCTGGGACTGATGCGACTTCTGGCCAAGAAGCGGGA
CGCGTACGCCCGGGAGTTCGGCATCGACGTTCGCGTGGTAGGAGTCGCGGATTCTCGAGGTGTCTGGGTGAAAAACGACC
TGGACCCCGCCGAAGTGCTGAAGGTTAAGCAGGAACTGGGTACCGTGGCGGAGGTCGGTGAGAGCGGCGATGCGTTGGAG
ATCATGGAGGACGTGGAGTTCGACGTTCTCGTGGAGCTTACGCCCACCGACATAGAAACGGGCGAGCCCGGTCTATCACA
CATCATGAAGGCCATAGAGTTGGGTAGGCACGTGGTAACTGCGAACAAGGGACCACTGGCCGTAGCTTACGGGGAAATCA
TGGAGGCAGCCGAGGAAGCCGGCGTCGTCGTGCGTTACGAGGCCACGGCCGGCGGGGCCATGCCCGTGTTCAACCTCGTA
CGCGAGACGCTGAAGAGTGTGGACATACATTCGATAGAGGGTGTACTCAACGGCACTGTCAACTACATCCTCACTAGGAT
GGAAGAAGAGGGCATATCCCTGAAGGACGCTATCGCCGAGGCGCAATCTCGTGGGATAGCCGAAGCGGATCCGAGTATGG
ACATCGAGGGATGGGATACCGCCTGTAAGGTCGTCATCCTCGCGAACGCCATCTTGGGACTGGACTGCACCATCAAGGAC
GTGGACGTTACAGGTATCGAGGACATTACACCCGAGGCCATTCGGATCGCGGAGGAGCGGGGCTACAGGATCAAATTGAT
CGGTCGAGCGGACAGCGACGGCGAGCTCTCGGTACGTCCGTGTCTGGTGCCGAAGTCCGACCCTGTGGCCAAGGTGAGAG
GCGTCATGAACATCGTGAGACTCGAGACTGACGTAGCGGGAGACATTTACGTGTCGGGTCGGGGCGCCGGTCCCTTAGAA
ACCGCTAGCGCCGTCATGAGCGATGTCCTCTCCATCGCCGAGAGCGTTGGTTAG

Upstream 100 bases:

>100_bases
TCTACGAAGACGAGGAGGCGCTGAGGAAAGCCGTCCAGACCATCGAGGAGATCGCTGAAGAGAAGGATCTTGTGGCCATC
TTCCCGGTGGAGGTGATACA

Downstream 100 bases:

>100_bases
GGCCGGTCCGAAGTGTTCGACGTGGTGTTTTCAGGCCGGAACTTAGTCGGTCATCTCCATCCTAGGATTTCGAGCAACGC
CCTAACTGGGTTCCAAGGAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRQARLFVIGLGAVGLGLMRLLAKKRDAYAREFGIDVRVVGVADSRGVWVKNDLDPAEVLKVKQELGTVAEVGESGDALE
IMEDVEFDVLVELTPTDIETGEPGLSHIMKAIELGRHVVTANKGPLAVAYGEIMEAAEEAGVVVRYEATAGGAMPVFNLV
RETLKSVDIHSIEGVLNGTVNYILTRMEEEGISLKDAIAEAQSRGIAEADPSMDIEGWDTACKVVILANAILGLDCTIKD
VDVTGIEDITPEAIRIAEERGYRIKLIGRADSDGELSVRPCLVPKSDPVAKVRGVMNIVRLETDVAGDIYVSGRGAGPLE
TASAVMSDVLSIAESVG

Sequences:

>Translated_337_residues
MRQARLFVIGLGAVGLGLMRLLAKKRDAYAREFGIDVRVVGVADSRGVWVKNDLDPAEVLKVKQELGTVAEVGESGDALE
IMEDVEFDVLVELTPTDIETGEPGLSHIMKAIELGRHVVTANKGPLAVAYGEIMEAAEEAGVVVRYEATAGGAMPVFNLV
RETLKSVDIHSIEGVLNGTVNYILTRMEEEGISLKDAIAEAQSRGIAEADPSMDIEGWDTACKVVILANAILGLDCTIKD
VDVTGIEDITPEAIRIAEERGYRIKLIGRADSDGELSVRPCLVPKSDPVAKVRGVMNIVRLETDVAGDIYVSGRGAGPLE
TASAVMSDVLSIAESVG
>Mature_337_residues
MRQARLFVIGLGAVGLGLMRLLAKKRDAYAREFGIDVRVVGVADSRGVWVKNDLDPAEVLKVKQELGTVAEVGESGDALE
IMEDVEFDVLVELTPTDIETGEPGLSHIMKAIELGRHVVTANKGPLAVAYGEIMEAAEEAGVVVRYEATAGGAMPVFNLV
RETLKSVDIHSIEGVLNGTVNYILTRMEEEGISLKDAIAEAQSRGIAEADPSMDIEGWDTACKVVILANAILGLDCTIKD
VDVTGIEDITPEAIRIAEERGYRIKLIGRADSDGELSVRPCLVPKSDPVAKVRGVMNIVRLETDVAGDIYVSGRGAGPLE
TASAVMSDVLSIAESVG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=336, Percent_Identity=23.8095238095238, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=25.4189944134078, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 35881; Mature: 35881

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQARLFVIGLGAVGLGLMRLLAKKRDAYAREFGIDVRVVGVADSRGVWVKNDLDPAEVL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCHHHHH
KVKQELGTVAEVGESGDALEIMEDVEFDVLVELTPTDIETGEPGLSHIMKAIELGRHVVT
HHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEE
ANKGPLAVAYGEIMEAAEEAGVVVRYEATAGGAMPVFNLVRETLKSVDIHSIEGVLNGTV
CCCCCEEEEHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
NYILTRMEEEGISLKDAIAEAQSRGIAEADPSMDIEGWDTACKVVILANAILGLDCTIKD
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEE
VDVTGIEDITPEAIRIAEERGYRIKLIGRADSDGELSVRPCLVPKSDPVAKVRGVMNIVR
CCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
LETDVAGDIYVSGRGAGPLETASAVMSDVLSIAESVG
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQARLFVIGLGAVGLGLMRLLAKKRDAYAREFGIDVRVVGVADSRGVWVKNDLDPAEVL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCCHHHHH
KVKQELGTVAEVGESGDALEIMEDVEFDVLVELTPTDIETGEPGLSHIMKAIELGRHVVT
HHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCEEEE
ANKGPLAVAYGEIMEAAEEAGVVVRYEATAGGAMPVFNLVRETLKSVDIHSIEGVLNGTV
CCCCCEEEEHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
NYILTRMEEEGISLKDAIAEAQSRGIAEADPSMDIEGWDTACKVVILANAILGLDCTIKD
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEE
VDVTGIEDITPEAIRIAEERGYRIKLIGRADSDGELSVRPCLVPKSDPVAKVRGVMNIVR
CCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
LETDVAGDIYVSGRGAGPLETASAVMSDVLSIAESVG
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]